The 2nd cell cycle checkpoint is:

The main cyclin-cdk complex involved in G2/M checkpoint is:

_-Cdk actively enhances M-cyclin transcription

S-Cdk phosphorylates _______ , allowing Plk1 to bind

S-Cdk phosphorylates FoxM1, allowing _____ to bind

M-Cdk activity is regulated by ____________

M-cyclin binding to M-Cdk is enough to fully activate the Cdk

__________ aids in additon of phosphate groups

Cdc25 phosphatase aids in the ________ of inhibitory phosphates from M-cdk

Which of these activates M-Cdk

Control of activation of M-Cdk is carried out by:

Activation of M-Cdk is carried out by:

at the end of G2 there is an abundance of _________ M-Cdk

M-Cdk is first activated at the _________

M-Cdk moves to the nucleus in the late ___phase

Which of these regulators block cell cycle progression at the G2/M checkpoint?

G1/S-cyclin levels are insignificant to the outcome of the G2/M checkpoint

G1/S-Cdk is inactivated by:

The 3 enzymes involved in ubiquitination of G1/S-cdk are E1, E2 and E3

M-Cdk is inactivated by ___ CKI

____ adds inhibitory phosphates to Cdc25, preventing its activity

Phosphorylation of ___ occurs, activating it and causing transcription of p21 which inactivates M-Cdk

Which regulator promotes cell cycle entry at the G2/M checkpoint

M-Cdk activates two protein kinase families, these are:

M-Cdk, Plk, Aurora-A and Aurora-B all promote cell cycle progression