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WorksheetsGenPath 2nd shifting LE - Renal Disease
Total questions: 20
Worksheet time: 10mins
A 12 year old complains of swelling of her eyelids, abdomen, and ankles. She had been in good health until several months ago, when she gained weight and noted swelling of lower legs. X-ray showed bilateral pleural effusion. Urinalysis showed heavy proteinuria (8g/24 hrs) without hematuria. Biopsy showed no morphologic abnormality by light microscope. Which best describes the patient's condition?
Amyloid nephropathy
Focal segmental glomerulosclerosis
Membranous nephropathy
Nephrotic syndrome
An 8 year old boy with a previous history of sore throat 2 weeks ago complained of headache, dizziness, and malaise. PE shows facial edema and elevated BP 180/100 mmHg. A 24 hour urine collection demonstrates oliguria, and urinalysis shows hematuria. What is the most lkely diagnosis?
Hereditary nephritis
Post-infectious glomerulonephritis
Thin glomerular basement membrane nepropathy
Membranous glomerulonephritis
Which of these stages of renal failure has a GFR or less than 20-25% of normal and patients have edema, metabolic acidosis, hyperkalemia, and overt uremia?
Diminished renal reserve
Renal insuffieciency
Chronic renal failure
End stage renal disease
In the pathogenesis of glomerular injury, this is due to intrinsic glomerular antigens
Circulating immune complex deposition
Cytotoxic antibodies
Heymann nephritis
Activation of alternative complement pathway
This is the classic example of nephritic syndrome associated with post-streptococcal infection
Acute proliferative glomerulonephritis
Rapid-progressive glomerulonephritis
Minimal change disease
Membranous glomerulonephritis
In nephrotic syndrome, which is NOT TRUE?
Massive proteinuria is caused by capillary damage
Hypoalbuminemia is a result of depletion of serum albumin
Generalized edema is caused mainly by sodium & water retention
Hyperlipidemia is a result of increased synthesis, abnormal transport and catabolism of lipids
Which of these glomerular disorders is associated with HIV infection and heroin addiction?
Acute proliferative glomerulonephritis
Rapid-progressive glomerulonephritis
Minimal change disease
Focal segmental glomerulosclerosis
This is a genetic disease with thin basement membrane disorder manifested by chronic renal failure, nerve deafness and ocular disorders
Henoch-Schonlein Purpura
Alport syndrome
Berger disease
Goodpasture syndrome
This syndrome manifests as purpuric skin lesions, abdominal symptoms including bleeding, nonmigratory arthralgia and renal abnormalities
Henoch-Schonlein Purpura
Alport syndrome
Berger disease
Goodpasture syndrome
Which is not a morphologic change in diabetic nephropathy?
Capillary basement membrane thickening
Diffuse mesangial sclerosis
Deposition of IgG in the GBM
Nodular glomerulosclerosis
Which of the following is the most frequent cause of nephrotic syndrome in children?
Membranous nephropathy
Minimal change disease
Focal segmental glomerulosclerosis
Membranoproliferative glomerulonephritis
Which of the ff. diseases suggest activation of the alternative complement pathway, in which there is decrease in serum C3 but normal C1 and C4?
Membranous nephropathy
Minimal change disease
Membranoproliferative glomerulonephritis type I
Membranoproliferative glomerulonephritis type II
Most common malignant renal tumor in children
Renal cell carcinoma
Wilms tumor
Rhabdoid tumor
Pheochromocytoma
Most common variant of renal cell carcinoma
Papillary
Clear cell
Sarcomatoid
Chromophobe
Major risk factor for the development of urothelial cell carcinomas
Hepatitis B
Phenacetin
S. haematobium
H. pylori
Most useful laboratory test in diagnosing streptococcal glomerulonephritis
Renal biopsy
ASO titer
CBC
Urinalysis
A 65-year-old male retired factory worker presents with weight loss and a palpable mass in the left abdomen. He noted that he has tea colored urine. What is the most likely diagnosis?
Nephrotic syndrome
Renal stone
Renal cell carcinoma
Acute glomerulonephritis
A 4-year-old child was brought to OMMC after her parents noticed a left sided renal mass, initially small but however progressively became large and asymmetrical. The child also had hematuria and frank blood clots. What is the most likely diagnosis?
Nephrotic syndrome
Nephroblastoma
Renal cell carcinoma
Acute glomerulonephritis
A 7-year-old boy presents with acute onset edema and facial swelling. Dipstick urinalysis reveals 4+ proteinuria. Renal biopsy shows no appreciable changes under the light and fluorescence microscopy, but electron microscopy demonstrates glomerular epithelial foot process effacement. What is the most likely diagnosis?
Minimal change disease
Acute proliferative glomerulonephritis
Cresentric glomerulonephritis
Post-streptococcal glomerulonephritis
Large multicystic kidneys, liver cysts, and berry aneurysms
Medullary sponge kidney
Familial juvenile nephronophthisis
Adult polycystic kidney disease
Childhood polycystic kidney disease
