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WorksheetsMODULE 5 DDS PINK PACOP 1-100
Total questions: 100
Worksheet time: 50mins
Name
Class
Date
1.
It is the process of comminution in which a paste is formed by combining the powder material and a small amount of liquid in which the powder is insoluble.I. levigation II. Pulverization by intervention III. Spatulation
a)
a. I only
b)
b. III only
c)
c. I and II
d)
d. II and III
e)
e. I, II and III
2.
Powders containing deliquescent and hygroscopic materials should be wrapped in what kind of paper? I. Vegetable parchment II. Glassine paper III. Waxed paper
a)
a. I only
b)
b. III only
c)
c. I and II
d)
d. II and III
e)
e. I, II and III
3.
This method is used when a small amount of potent substances is to be mixed with a large amount of diluents.
a)
a. Block and divide method
b)
b. geometric dilution
c)
c. trituration
d)
d. Spatulation
e)
e. sifting
4.
In preparing effervescent granulated salts, which of the following statement/s hold/s true? I. Effervescent granules can be prepared using two methods, the dry and wet methods. II. The effervescence from the released CO2 serves to mask the bitter or salty taste of drugs. III. Using tartaric acid as the sole acid would result in a sticky mixture which is difficult to granulate.
a)
a. I only
b)
b. I and II
c)
c. I, II and III
d)
d. III only
e)
e. II and III
5.
Which of the following powders can be classified as bulk powders? I. Douche II. Dusting powder III. Insufflation
a)
a. I only
b)
b. I and II
c)
c. III only
d)
d. II and III
e)
e. I, II and III
6.
The following statement/s hold/s true for capsules: I. They are solid dosage forms in which material agents &/ or inert substance are enclosed within a small shell of gelatin. II. Gelatin capsules may be hard or soft depending on their composition. III. Soft gelatin capsules are used by community pharmacist in the extemporaneous compounding of prescriptions.
a)
a. I only
b)
b. I and II
c)
c. I, II and III
d)
d. III only
e)
II and III
7.
Normally how many % of water is contained in a hard gelatin capsule?
a)
a. 8-10
b)
b. c. 20-25
c)
c. e.5-10
d)
d. 12-16
e)
e. d. 2-5
8.
The largest size of hard, empty capsule that can be swallowed is:
a)
a. 00
b)
b. 00
c)
c. 0
d)
d. 000
e)
e. 5
9.
The following statement/s is/are true: <br />I. Gelatin is obtained by the partial hydrolysis of collagen obtained from the skin, white connective tissue and bones of animals. <br />II. Although gelatin is insoluble in cold water, it does soften through the absorption of up to ten times the weight of the water. <br />III. Gelatin is soluble in hot water and in warm gastric fluid; a gelatin capsule rapidly dissolves and exposes its contents.
a)
a. I only
b)
b. III only
c)
c. I and II
d)
d. II and III
e)
e. I, II and III
10.
Prolonged exposure to high humidity can affect in vitro dissolution of capsules containing: <br />I. tetracycline <br />II. Chloramphenicol <br />III. Nitrofurantoin
a)
a. I only
b)
b. I and II
c)
c. I, II and III
d)
d. III only
e)
e. II and III
11.
This chemical agent is used to render the capsule opaque:
a)
a. titanium dioxide
b)
b. Magnesium oxide
c)
c. lactose
d)
d. Sorbitol
e)
e. Silica
12.
The following statement/s is/are true for soft gelatin capsules (SGC): I. SGC is made of gelatin to which glycerin or a polyhydric alcohol has been added. II. Methyl parabens can be used as preservatives to retard microbial growth. III.SCGs can be prepared using the “punch” method and also require opaquants to reduce transparency and render characteristics feature to the capsule shell.
a)
a. I only
b)
b. I and II
c)
c. I, II and III
d)
d. III only
e)
e. II and III
13.
Types of liquids that may be encapsulated into soft gelatin capsules include the following: I. Vegetable and aromatic oils II. Propylene glycol III. Polyethylene glycols
a)
a. I only
b)
b. I and II
c)
c. I, II and III
d)
d. III only
e)
II and III
14.
Substances added to capsules must possess the following characteristic/s: I. Are harmless in the quantities used II. Do not exceed the minimum amounts required to provide their intended effect III. Do not impair the product’s bioavailability, therapeutic efficacy or safety
a)
a. I only
b)
b. I and II
c)
c. I, II and III
d)
d. III only
e)
e. II and III
15.
These are compressed tablets coated with substances that resist dissolution in gastric fluid but integrate in the intestine. I. Film-coated tablets II. Sugar-coated tablets III. Enteric-coated tablets
a)
a. I only
b)
b. I and II
c)
c. I, II and III
d)
d. III only
e)
e. II and III
16.
This type of coating imparts the same general characteristics as sugar coating with the added advantage of greatly reduced time period required for the coating operation. I. Enteric coating II. Single-layer coating III. Film coating
a)
a. I only
b)
b. I and II
c)
c. I, II and III
d)
d. III only
e)
e. II and III
17.
These tablets were originally used by physicians in the extemporaneous preparation of parenteral solutions. I. Chewable tablets II. Dispensing tablets III. Hypodermic tablets
a)
a. I only
b)
b. I and II
c)
c. I, II and III
d)
d. III only
e)
e. II and III
18.
Enteric-coated tablets have the following characteristic/s: I. Have delayed-release features II. The containing system used should only be aqueous-based and not organic-solvent based to resist the breakdown in gastric fluids II. Are intended to pass through the stomach intact to disintegrate and release their drug-content for absorption along the intestines
a)
a. I only
b)
b. I and III
c)
c. I, II and III
d)
e. II & III
e)
e. III only
19.
Example of materials used in enteric coating includes: I. Shellac II. Cellulose acetate phthalate III. Polyvinyl acetate phthalate
a)
a. I only
b)
b. II only
c)
c. I, II and III
d)
d. I and II
e)
e. II and III
20.
The following statement/s is/are true for compressed tablets: I. These are tablets formed by compression and may contain other special coating if desired. II. Tablet diameters and shapes are determined by the die and punches used in the compression of the tablet. III. They are made from powdered, crystalline or granular materials, alone or in combination with binders, disintegrants, controlled-release polymers, lubricants, diluents and colorants.
a)
a. I only
b)
b. II only
c)
c. I, II and III
d)
d. I and II
e)
e. II and III
21.
This is a method of preparing tablets in which the powder mixture is compacted in large pieces and subsequently broken down or sized into granules.
a)
a. Wet granulation
b)
b. Dry granulation
c)
c. Direct compression
22.
For some granular chemicals like potassium chloride, this method of preparation is of an advantage to use.
a)
a. Wet granulation
b)
b. Dry granulation
c)
c. Direct compression
23.
The problems most commonly encountered during direct compression include: I. Capping II. Splitting III. Lamination
a)
a. I only
b)
b. II and III
c)
c. I and III
d)
d. III only
e)
e. I, II and III
24.
For chemicals which do not possess cohesive and free-following properties, the following excipients could be used to impart necessary qualities for the production of tablets b direct compression. I. Spray-dried lactose II. Magnesium stearate III. Fume silicon dioxide
a)
a. I only
b)
b. I and II
c)
c. II and III
d)
d. II only
e)
e. I, II and III
25.
The following statement/s is/are true for wet granulation method: I. Liquid binder is added to the powder mixture to facilitate the adhesion of the powder particles II. Over-wetting of the powder can result in granules that are too soft for proper tableting and under-wetting can result in tablets that are too hard III. Granules may be dried in thermostatically controlled ovens which constantly record the time, temperature and humidity.
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
26.
Lubricants contribute to the preparation of compressed tablets by: I. Improving the flow of granulation in the hopper to die cavity II. Preventing the adhesion of the tablet formulation to the punches and dies during compression III. Reducing friction between the tablet and die wall during the tablet’s ejection from the tablet machine
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
27.
A fluid-bed granulator performs which of the following steps? I. Preblends the formulation powder, including active ingredients, fillers, disintegrants, in a bed by fluidized air. II. Granulates the mixture by spraying onto the fluidized powder bed, suitable liquid binder, as an aqueous solution of acacia, hydroxypropyl cellulose or povidone III. Drying the granulated product to the desired moisture content
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
28.
Dry granulation: Used for tablet I. Ingredients that is sensitive to moisture or unable to withstand elevated temperature during drying II. One of the constituents, either the active ingredient or the diluents, must have cohesive properties III. Includes more number of steps than wet granulation
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
29.
Aspirin, which is hydrolyzed on exposure to moisture, is prepared into tablet using the dry granulation method. Other drugs which should be prepared using this process include: I. Ascorbic acid II. Methenamine III. Thiamine HCl
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
30.
This process is a form of pelletization, which refers to the formation of spherical particles from wet granulations.
a)
a. Spheronization
b)
b. Slugging
c)
c. Compaction
d)
d. Precompression
e)
e. Double compression
31.
This method consists of bringing together a highly dispersed liquid and a sufficient volume of hot air to produce evaporation and drying of the liquid droplets.
a)
a. Spray drying
b)
b. Spray congealing
c)
c. Spray chilling
d)
d. Moist heating
e)
e. Dry heating
32.
Spray-dried powder particles possess the following characteristic/s: I. They are homogenous, approximately spherical in shape and nearly uniform in size. II. Have low bulk density with rapid rate of solution III. Preparation is less economical than other processes
a)
a. I only
b)
b. III only
c)
c. I & II
d)
d. II & III
e)
e. I, II, III
33.
This the only carbohydrate used in the preparation of compressed tablet which possesses high heat stability.
a)
a. lactose
b)
b. mannitol
c)
c. sucrose
d)
d. starch
e)
e. fructose
34.
The following statement/s is/are true used in the preparation of sugar-free chewable tablets? I. Mannitol is used as the excipient in most chewable tablets. II. These tablets are formulated to disintegrate smoothly in the mouth with or without active chewing. III. These tablets are particularly useful for children and adults who have difficulty swallowing other solid dosage forms
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
35.
Which excipient/s is/are used in the preparation of sugar-free chewable tablets? I. Lactose II. Dextrose III. Xylitol
a)
a. I only
b)
b. III only
c)
c. I & II
d)
d. II & III
e)
e. I, II, III
36.
Tablet coating has the following advantage/s: I. Protect the medicinal agent destructive exposure to air and/or humidity II. Mask the unpleasant taste of the drug III. Provide special characteristics of drug release
a)
a. I only
b)
b. I & II
c)
c. II & III
d)
d. I & III
e)
e. I, II, III
37.
Film coated tablets possess the following characteristic/s: I. Less resistant to destruction by abrasion than are sugar coated tablets II. Coating may be colored to make tablets attractive and distinctive III. Film-coating solutions may be non-aqueous or aqueous
a)
a. I only
b)
b. I & II
c)
c. II only
d)
d. II & III
e)
e. III only
38.
This substance provides water solubility or permeability to the film to ensure penetration by body fluids and therapeutic availability of the drug.
a)
a. alloying substance
b)
b. Plasticizer
c)
c. film former
d)
d. surfactant
e)
e. glossant
39.
Problems encountered on the use of aqueous based film coating solution include: I. Slow evaporation of the solvent-based solutions II. Expensive as compared to volatile solvents III. Increased likelihood of water interference with the tablet formulation
a)
a. I only
b)
b. III only
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
40.
AQUACOAT is a commercially available water-based colloidal coating dispersion which contains 30% ethyl cellulose pseudo latex. Pseudo latex dispersion has: I. A high solid content for greater coating activity II. Low viscosity which allows less water to be used in the coating dispersion III. Low viscosity which permits greater coat penetration into the crevices of monogrammed or scored tablets
a)
a. I only
b)
b. III only
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
41.
This is a problem often encountered in film coating process characterized by roughness of the tablet surface due to failure of spray droplets to coalesce.
a)
a. peeling
b)
b. picking
c)
c. orange-peel effect
d)
d. mottling
e)
e. bridging
42.
This problem corresponds to the filling-in of the score line or indented logo on the tablet by the film.
a)
a. peeling
b)
b. picking
c)
c. orange-peel effect
d)
d. mottling
e)
e. bridging
43.
This problem is characterized by the appearance of small amounts of film fragments flaking from the tablet surface
a)
a. peeling
b)
b. picking
c)
c. orange-peel effect
d)
d. mottling
e)
e. bridging
44.
The following statement/s is/are true for pills: I. Are small, round, solid dosage form containing a medicinal agents and intended to be administered orally II. Have been replaced today by compressed tablets and capsules III. Are placed in the mouth, where they dissolve slowly, liberating the active ingredient
a)
a. I only
b)
b. III only
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
45.
These are forms of oral medication which are discoid-shaped solids containing the medicinal agent in a suitably flavored base. I. Troches II. Pastilles III. Lozenges
a)
a. I only
b)
b. III only
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
46.
The following drug is/are available in pellet forms: I. Testosterone II. Estradiol III. Desoxycorticosterone
a)
a. I only
b)
b. III only
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
47.
This type of dosage form allows a reduction in dosing frequency to that presented by a conventional dosage form.
a)
a. Extended-release
b)
b. Delayed-release
c)
c. Repeat action
d)
d. Modified-release
e)
e. Targeted release
48.
This type dosage form is designed to release the drug form at a time other than promptly after administration.
a)
a. Extended-release
b)
b. Delayed-release
c)
c. Repeat action
d)
d. Modified-release
e)
e. Targeted release
49.
The following statement/s hold/s true for extended-release dosage forms: I. There is reduction in drug blood level fluctuations. II. There is frequency reduction in dosing III. There is reduction in terms of adverse side effects.
a)
a. I only
b)
b. I & II
c)
c. II only
d)
d. II & III
e)
e. I, II, III
50.
In general, the drugs best suited for incorporation into an extended-release product have the following characteristic/s: I. Exhibit either very slow or very fast rates of absorption and excretion II. Are uniformly absorbed from the gastrointestinal tract III. Used in the treatment of acute rather than chronic conditions
a)
a. I only
b)
b. I & II
c)
c. II only
d)
d. II & III
e)
e. III only
51.
This is process by which solids, liquids or even gases may be encapsulated into miscroscopic size particles through the formation of thin coating of “wall” material around the substance being encapsulated. I. Microencapsulation II. Microscoencapsulation III. Micromeritics
a)
a. I only
b)
b. III only
c)
c. I & II
d)
d. II & III
e)
e. I, II, III
52.
The following statement/s is/are true when embedding drug in inert plastic matrix: I. The drug is granulated with an inert plastic material such as polyethylene and the granulation is compressed into tablets II. The drug is rapidly released from the inert plastic matrix by diffusion. III. The compression of the tablet creates the matrix or plastic form that retains its shape during the leaching of the drug and through its passage through the alimentary tract.
a)
a. I only
b)
b. I & II
c)
c. II only
d)
d. I & III
e)
I, II, III
53.
The effectiveness of the hydrophilic matrix systems is based on the successive processes of: I. Hydration of the cellulose polymer II. Gel formation on the polymer’s surface III. Tablet erosion and subsequent and continuous release of the drug
a)
a. I only
b)
b. III only
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
54.
Which of the following statement/s on drug release form the dosage form is correct: I. The release of the drug in a drug-resin complex is dependent upon the pH of the GIT only. II. The release of the drug in a drug-resin complex is dependent upon the pH and the electrolyte concentration in the GIT. III. Release is less in the acidity of the stomach than in the less acidic environment of the small intestines.
a)
a. Only the first statement is true
b)
b. Only the second statement is true
c)
c. The first two statements are true
d)
d. The last two statement are true
e)
e. All the true
55.
These tablets are prepared so that an initial dose of drug is released immediately followed later by a second dose.
a)
a. Extended-release
b)
b. Delayed-release
c)
c. Repeat action
d)
d. Modified-release
e)
e. Targeted release
56.
The following statement/s is/are true for ophthalmic inserts: I. Eliminates the problem of rapid loss of administered drug due to the blinking of the eye and flushing of lacrimal fluids II. The rate of drug diffusions is controlled by the polymer composition, membrane thickness, and solubility of the drug. III. Ocusert and lacrisert are example of ophthalmic inserts
a)
a. I only
b)
b. III only
c)
c. I & II
d)
d. II & III
e)
e. I, II, III
57.
These are solid dosage forms which are designed to be inserted under the skin by special injectors or by surgical incision.
a)
a. Implants
b)
b. Cachets
c)
c. Plasters
d)
d. Pills
e)
e. Troches
58.
The following should be observed in the use of oral modified-release dosage forms: I. These products should not be crushed or chewed. II. Nonerodible plastic matrix shells and osmotic tablets remain intact throughout GI transmit and empty shell or “ghost” from osmotic tablets may be seen in stool III. Patients being fed by enteral nutrition through a nasogastric feeding tube should not receive this type of drug.
a)
a. I only
b)
b. III only
c)
c. I & II
d)
d. II & III
e)
e. I, II, III
59.
The release of a drug from an oral dosage form may be intentionally delayed until it reaches the intestines for several reasons. The purpose may be:
a)
a. to protect the drug destroyed by gastric fluids
b)
b. to reduce gastric distress caused by drugs particularly irritating to the stomach
c)
c. to facilitate GI transit for drugs which are better absorbed from the intestines
d)
d. A & B only
e)
e. AOTA
60.
60. It is the most common “wall” forming material used in microencapsulation.
a)
a. lactose
b)
b. gelatin
c)
c. dextrose
d)
d. sorbitol
e)
e. starch
61.
The following statement/s is/are true for ointments: I. These are semi-solid preparations intended for external application to the skin or mucous membranes. II. They may be medicated or nonmedicated III. Nonmedicated ointments are used as protectants, emollients or lubricants.
a)
a. I only
b)
b. I & II
c)
c. II & III
d)
d. III only
e)
e. I, II, III
62.
The following statement/s is/are true for hydrocarbon bases: I. Also termed as oleaginous bases II. Have an emollient effect and are effective as occlusive dressing III. Permit the incorporation of powdered substances with the use of a levigating agent
a)
a. I only
b)
b. I & II
c)
c. II & III
d)
d. III only
e)
e. I, II, III
63.
. Yellow ointment is an example of
a)
a. Hydrocarbon base
b)
b. Oleaginous base
c)
c. Absorption base
d)
d. Water-removable base
e)
e. A& B
64.
The following ointment base/s is/are classified as hydrocarbon base/s: I. Petrolatum II. White ointment III. Polyethylene Glycol Ointment
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. III only
e)
e. I, II, III
65.
Petrolatum, USP is:
a)
a. A purified mixture of semi-solid hydrocarbons from petroleum that has been wholly or nearly decolorized
b)
b. Also known as Yellow ointment
c)
c. Is also known as white Vaseline
d)
d. Water-soluble
e)
e. Water-washable
66.
Yellow ointment USP is: I. Also called as “Simple Ointment” II. Has Yellow wax and petrolatum as the main ingredients III. Bleached and purified wax obtained from the honeycomb of the bee, Apis mellifera
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. III only
e)
e. I, II, III
67.
The following statement/s is/are true for absorption bases: I. These bases permit the incorporation of aqueous solution resulting in the formation of water-in-oil emulsions II. These bases are not easily removed from the skin with water III. These bases may be used as emollient although they do not provide the degree of occlusions afforded by hydrocarbon bases.
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II & III
e)
e. I, II, III
68.
Hydrophilic petrolatum is:
a)
a. Hydrocarbon base
b)
b. Oleaginous base
c)
c. Absorption base
d)
d. Water-removable base
e)
e. Water-soluble
69.
Lanolin USP: I. Is classified as hydrocarbon ointment base II. Contains not more than 2% of water III. Is a purified, wax-like substance that has been cleaned, deodorized and decolorized
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. III only
e)
e. I, II, III
70.
These are ointment bases which resemble creams in appearance.
a)
a. Hydrocarbon base
b)
b. Water-soluble base
c)
c. Absorption base
d)
d. Water-removable base
e)
e. Oleaginous base
71.
The following statement/s is/are true for Hydrophilic Ointment USP: I. When preparing, stearyl alcohol and white petrolatum are melted together at 90 degrees II. Stearyl alcohol and white petrolatum comprise the oleaginous phase of the emulsion III. Sodium lauryl sulfate acts as the emulsifying agent
a)
a. I only
b)
b. III only
c)
c. I & II
d)
d. II & III
e)
e. I, II, III
72.
These ointment bases are referred to as “greaseless” bases.
a)
a. Hydrocarbon base
b)
b. Water-soluble base
c)
c. Absorption base
d)
d. Water-removable base
e)
e. Oleaginous base
73.
Polyethylene glycol Ointment, NF is:
a)
a. Hydrocarbon base
b)
b. Water-soluble base
c)
c. Absorption base
d)
d. Water-removable base
e)
e. Oleaginous base
74.
The following statement/s is/are true for ointment base: I. Water-soluble bases have the ability to absorb serous discharges II. Hydrocarbon bases can remain on the skin for prolonged periods of time without drying out III. Water-removable bases can also be called as water-soluble bases.
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II only
e)
e. I, II, III
75.
The following statement/s is/are true for the preparation of ointment using the incorporation method. I. By this method, the components are mixed until a uniform preparation is attained II. This method does not involved the process of levigating III. Mortar and pestle or spatula may be used to rub the ingredients together on an ointment slab
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II only
e)
e. I, II, III
76.
The following statement/s is/are true about levigation: I. Levigation allows both reduction of particle size and the dispersion of the substance in the vehicle. II. Glycerin is the levigating agent used for bases where water is the external phase III. The amount of levigating agent used should be about equal in volume to the solid maerial.
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II only
e)
e. I, II, III
77.
The following statement/s is/are true for the preparation of ointments by fusion: I. All or some of the components of an ointment are combined by being melted together and cooled with constant stirring until congealed. II. Heat-labile substances are added last when the temperature of the mixture is low enough. III. Medicated ointments containing beeswax, paraffin, stearyl alcohol are prepared using this method.
a)
a. I only
b)
b. I & II
c)
c. I & III
d)
d. II only
e)
e. I, II, III
78.
These are semi-solid preparation containing one or more medicinal agents dissolved or dispersed in either an oil-in-water emulsions or in another type of water-washable base.
a)
a. Creams
b)
b. gel
c)
c. paste
d)
d. ointments
e)
e. lotion
79.
The following statement/s is/are true: I. I. Vanishing creams are water-in-oil emulsions containing small amounts of water. II. Creams find primary application in topical skin products and in products used rectally and vaginally III. Ointments are preferred more by patients due to ease of spreadability
a)
a. I only
b)
b. I & II
c)
c. II only
d)
d. I & III
e)
e. I, II, III
80.
These are semi-solid systems consisting of dispersion of small or large molecules in an aqueous liquid vehicle rendered jelly-like through the addition of a gelling agent.
a)
a. Creams
b)
b. Gel
c)
c. Gelatin
d)
d. Ointments
e)
e. Pastes
81.
The following statement/s is/are true regarding gels: I. Gels may thicken on standing, forming a thixotrope and must be shaken before use. II. Milk of magnesia is an example of a single-phase gel III. Gels and jellies are two different terms
a)
a. I only
b)
b. I & II
c)
c. II only
d)
d. I & III
e)
e. I, II, III
82.
The following statement/s is/are true for pastes: I. They generally contain a smaller proportion of solid material than ointments. II. They are less greasy and less stiff than their counterpart ointments due to reduced amount of based used. III. They remain in place after application and are effectively employed to absorb serous secretions.
a)
a. I only
b)
b. I&II
c)
c. I&III
d)
d. III only
e)
e. I, II, III
83.
Zinc oxide paste: <br />I. Can be applied to hairy parts of the body <br />II. Prepared by levigating and mixing 25% each of zinc oxide and starch with white petrolatum <br />III. Also known as Lassar’s Plain Zinc Paste
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II
84.
These are solid or semi-solid adhesive masses spread upon a backing material of Paper, fabric, moleskin or plastic
a)
a. Creams
b)
b. Plasters
c)
c. Paste
d)
d. Ointments
e)
e. Lotion
85.
How many % of glycerin is contained in a glycerogelatin preparation?
a)
a. 15%
b)
b. 35%
c)
c. 40%
d)
d. 5%
e)
e. 10%
86.
The following statement/s is/are true for glycerogelatins:<br />I. They are applied to the skin for long term residence<br />II. They are intended to be swallowed just like gelatin capsules <br />III. They are applied to the affected area with affine brush
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
87.
Zinc Gelatin:<br />I. Jelly<br />II. Used to treat varicose ulcers<br />III. Glycerogelatin
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
88.
The following statement/s is/are true for topical agents:<br />I. Pastes offer even greater occlusion and more effective than ointment at absorbing serous discharge<br />II. Ointment spread more easily than creams.<br />III. These agents also include ophthalmic solutions, suspensions, and inserts.
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
89.
The ointment base selected for an ophthalmic ointment must possess the following characteristic/s:<br /> I. Non-irritating to the eye <br />II. Permits the diffusion of the medicinal substance throughout the secretions bathing the eye<br /> III. Have a softening point close to the body temperature
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
90.
The use of ophthalmic ointments and gels offers the following advantage/s: <br />I. Provides extended residence time on the surface of the eye<br />II. Blurring of vision can be encountered<br />III. Increase the bioavailability for absorption into ocular tissues
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
91.
The factor/s which play/s a part in percutaneous absorption is/are:<br /> I. Molecular weight<br /> II. Partitioning coefficient <br /> III. solubility
a)
a. I only
b)
b. II only
c)
c. I&II
d)
d. II&III
e)
e. I, II, III
92.
The following statement/s is/are true about percutaneous absorption:<br /> I. The amount of drug percutaneously absorbed per unit of surface area per time interval increase as the concentration of the drug substance in the transdermal drug delivery system is increased.<br /> II. The hydration of the skin hinders percutaneous absorption <br /> III. The longer the period of time the medicated application is permitted to remain in contact with the skin, the greater will be the total drug absorption.
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
93.
The following statement/s is/are true about percutaneous absorption: <br />I. Drugs penetrate through the skin better in their unionized form.<br /> II. Non-polar drugs tend to cross the cell barrier through the lipid-rich regions (transcellular route) whereas the polar drugs favor transport between cells (intracellular)<br /> III. More drugs are absorbed when the drug substance is applied and concentrated on a smaller surface area.
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
94.
The selection of a permeation enhancer in developing a TDDS should be based on:<br />I. Efficacy in enhancing skin permeation<br />II. Biocompatibility with other components <br />III. Physicochemical compatibility with other components
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
95.
The design objectives of TDDS include:<br />I. To deliver the drug at an optimal rate of the skin for percutaneous absorption at the therapeutic levels<br /> II. To adhere well to the patient’s skin and have a patch-size, appearance and site-placement that encourage patient acceptance<br /> III. To occlude the skin to ensure the one-way flux of the drug into the stratum corneum
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
96.
Transdermal Drug Delivery System: <br />I. Avoids gastrointestinal drug absorption difficulties<br />II. Avoids the occurrence of contact dermatitis<br />III. Drug therapy cannot be terminated rapidly.
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
97.
e following can be formulated as TDDS i. Scopolamine ii. Nicotine iii. Clonidine
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
98.
Which of the following statement should be considered in the use of TDDS? i. Rotating locations within the recommended site should be avoided in the application of replacement patches. Ii. Wet or moist skin can hinder drug permeation beyond that which is intended iii. Use of skin lotions should be avoided at the application site because they affect skin hydration and can also alter the partition coefficient between the drug in the TDDS and the skin.
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
99.
This layer functions to store and release the drug at the skin-site.
a)
a. occlusive backing membrane
b)
b. release-liner
c)
c. matrix system
d)
d. hydrophilic layer
e)
e. Adhesive layer
100.
TDDS offers the following advantage/s: i. Avoid first-pass effect ii. Provide extended therapy with a single application iii. Non-invasive
a)
a. I only
b)
b. III only
c)
c. I&III
d)
d. II&III
e)
e. I, II, III
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