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Linkage Analysis

Total questions: 12

Worksheet time: 9mins

Name
Class
Date
1.

Linkage is a phenomenon seen during.....

a)

Mitosis

b)

Meiosis

c)

DNA replication

d)

During a mutation

2.

Crossingover occurs between

a)

Homologous Non sisters

b)

Homologous Sisters

c)

Between both homologous sisters and non sisters

d)

Occurs between different crhomosomes

3.

What is the difference between Chromatin and Chromosomes? (1 mark)

4 lines
4.

How many genes can be mapped with the help of a double crossover?

a)

3

b)

2

c)

4

d)

either 2 or 3

5.

How many progeny will be have if we have 3 genes that are being mapped?

a)

9

b)

8

c)

4

d)

6

6.

If the distance between A/B is 0.12 mu and gene C is on the opposite side of A with respect to B at a distance of 0.23 mu, Which is the central gene in this map

a)

A

b)

B

c)

C

d)

Data insufficient

7.

If the distance between A/B is 0.12 mu and gene C is on the opposite side of A with respect to B at a distance of 0.23 mu, What is the order of the gene linkage map

a)

A - B - C

b)

C - A - B

c)

both A - B - C and C - B - A are possible

d)

The linkage map cannot be detemined as the ratio is not 1:1

e)

A - C - B

8.

A cross is made between vermilion (v), scute (sc), yellow body (y) fly and a wild type fly. The F1 is test crossed and the F2 progeny are as follows: + + + = 489, v sc y = 470, + sc y = 210, v + + = 218, + + y = 10, v sc + = 6, + sc + = 156, v + y = 141. What is the distance between v & sc and which is the central gene. (1 mk)

a)

v/sc = 0.42 mu and v is the central gene

b)

v/sc = 0.24 mu and y is the central gene

c)

v/sc = 0.42 mu and y is the central gene

d)

v/sc = 0.24 and v is the central gene

9.

This is the reason why Mendel did not recognize linkage phenomenon in his experiments

a)

The characters he studied were present on different chromosomes

b)

He studied only pure characters

c)

He did not have a powerful microscope

d)

The characters he studied did show linkage but he missed it

10.
1 map unit is equal to:
a)
1 nm
b)
1% recombination
c)
1 chromosome
d)
1 mutation
11.
According to _______, genes that are closer together on a chromosome, have a higher chance of being inherited together.  
a)
Gene Linkage
b)
Polygenic
c)
Pleiotropy
d)
Epistasis
12.
A and B are linked genes. In a study of 100 offspring, 80 parental genotypes for A and B, while 20 were recombinants. A and B are how many map units apart? 
a)
10
b)
5
c)
20
d)
30