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WorksheetsMED20 Neoplasia catch up
Total questions: 25
Worksheet time: 24mins
What is the Human Papilloma Virus (HPV) an example of?
Indirect carcinogen
Pro carcinogen
Direct carcinogen
Complete carcinogen
Which of the following is true regarding UV exposure and carcinogenesis?
It causes indirect damage due to free radical generation
UV light exposure penetrates deeper than X-ray radiation
It is a risk factor in patients with vitamin D deficiency
It is less likely to cause direct damage to DNA
Which of the following is an example of a tumour suppressor gene?
cMYC
RAS
p53
BRACA
Which of the following is NOT one of the 6 Hallmarks of Cancer?
Cells that are able to invade and metastasise
Cells resistant to programmed cell death
Angiogenesis
Resistance to growth signals
Barrett’s oesophagus is an example of which of the following?
Squamous cell Carcinoma
Cell hyperplasia
Dysplasia
Adenocarcinoma
What is the most common cancer affecting the bladder?
Transitional cell carcinoma
Adenocarcinoma
Squamous cell carcinoma
Teratoma
What malignancy is commonly associated with this cell appearance?
Neuroendocrine tumour
Hodgkin’s Lymphoma
Non-Hodgkins Lymphoma
CML
Which of the following is true regarding benign tumours?
They are poorly differentiated but remain localised to site of origin
They are well differentiated but are likely to spread beyond their site of origin
They are less likely to cause local effects on surrounding tissue
They closely resemble their tissue of origin
E-Cadherin expression is reduced in
(a)
Matrix metalloproteinases (MMP) are important for
Stromal invasion of metastatic cells
Reduction in integrin expression of metastatic cells
Evading immune system
Angiogenesis
Which of the following cancers do NOT metastasise to bone?
Breast
Thyroid
Liver
Kidney
Which regional lymph nodes are likely to be affected in breast cancer?
Para-aortic lymph nodes
Axillary lymph nodes
Peri-hilar lymph nodes
Inguinal lymph nodes
What is this CXR showing an appearance of?
Which of the following is NOT a local effect of neoplasms?
Compression of the trachea in a bronchial tumour
SIADH caused by small cell lung cancer
Bleeding due to renal tumour invading renal artery
Bowel obstruction caused by colonic carcinoma
Which of the following cancers has the best 5 year prognosis?
Testicular cancer
Pancreatic cancer
Breast cancer
Malignant melanoma
This is an example of an anaplastic thyroid cancer histology - what grade is it likely to be?
G1
G2
G3
G4
A patient was diagnosed with colon cancer. Histology and imaging showed the cancer had shown it to have spread to the iliac lymph nodes. What stage of Duke’s criteria would this apply to?
Duke’s A
Duke’s B
Duke’s C
Duke’s D
A patient was recently diagnosed with Lung Cancer which is 5cm-4.2cm in the left upper lobe of the lung and local invasion of the main bronchus. There is no nodal involvement or mets. What TNM stage is the tumour?
T1 N0 M0
T2 N0 M0
T3 N0 M0
T2 N1 M0
A patient was diagnosed with invasive ductal carcinoma of the breast which showed positive sentinel node spread to 2 axillary lymph nodes with no evidence of metastasis. What is the TNM score?
T2 N2 M0
T1 N2 M0
T3 N1 M0
T3 N2 M0
Which of the following is a hormonal treatment used for treating cancer?
Cisplatin
Herceptin
5FU
Adalimumab
Which of the following is NOT a tumour marker for cancer?
KRAS
PSA
CEA
CA19-9
Give an example of a cancer screening programme in the NHS
The Philadelphia chromosome (BCR-ABL) is an oncogenes fusion protein that is associated with
(a)
Why might radiotherapy be considered in palliative cancer?
What are some of the side effects from chemotherapy?
