WorksheetsMed Chem Antiparasitics
Total questions: 36
Worksheet time: 24mins
Metronidazole acts against which bugs?
amebiasis
giardiasis
anaerobic bacterial infections ie Clostridium difficile
trichomoniasis
toxoplasmosis
Tinidazole acts against which bugs?
trichomoniasis
giardiasis
amebiasis
toxoplasmosis
cryptosporidium
Spiramycin acts against which bugs?
toxoplasmosis
cryptosporidium
trypanosomes
leishmaniasis
malaria
Pentamidine acts against which bugs?
trypanosomes
leishmaniasis
malaria
cryptosporidium
Atovaquone acts against which bugs?
trypanosomes
leishmaniasis
malaria
Nitazoxanide acts against which bugs?
cryptosporidium
malaria
leishmaniasis
trypanosomes
Paromomycin acts against which bugs?
cryptosporidium
trypanosomes
leishmaniasis
malaria
Quinine Sulfate acts against which bugs?
chloroquine-resistant plasmodium
Plasmodium vivax
Plasmodium ovale
Plasmodium falciparum
Primaquine acts against which bugs?
Plasmodium vivax
Plasmodium ovale
Plasmodium falciparum
chloroquine-resistant plasmodium
Pyrimethamine acts against which bugs?
used with quinine for chloroquine-resistant malaria
trypanosome
Plasmodium vivax
Albendazole acts against which bugs?
tapeworm
whipworm
roundworm
threadworm
hookworm
Mebendazole acts against which bugs?
roundworm
hookworm
pinworm
whipworm
threadworm
Thiabendazole acts against which bugs?
roundworm
hookworm
tapeworm
whipworm
threadworm
Ivermectin acts against which bugs?
Haemonchus contortus
various common intestinal worms
tapeworm
Praziquantel acts against which bugs?
cestodes
trematodes
nematodes
Pyrantel Pamoate acts against which bugs?
hookworm
roundworm
pinworm (drug of choice)
tapeworm
threadworm
Which of the following are true?
Metronidazole is a prodrug- nitro is reduced to hydroxylamine by organism, hydroxylamine allows for nonspecific binding
Tinidazole has the same MOA as metronidazole
Spiramycin is teratogenic which is why it is not FDA approved
Which of the following drugs does this MOA belong to? Disruption of mitochondrial protein synthesis; concentrates in lungs, sinuses and female pelvic tissues; crosses placenta and distributes to breast milk
Spiramycin
Metronidazole
Tinidazole
Nitazoxamide
Which of the following drugs does this MOA belong to? Prodrug; nitro is reduced to hydroxylamine by organism, hydroxylamine allows nonspecific binding to DNA, protein and membranes of organism
metronidazole
tinidazole
atovaquone
paromomycin
Which of the following drugs does this MOA belong to? inhibits topoisomerase in P. carinii although MOA is thought to be different in different organisms (in trypanosoma: binds DNA)
pentamidine
atovaquone
nitazoxanide
paromomycin
Which of the following drugs does this MOA belong to? ubiquinone reductase inhibitor (structural similarity to ubiquinone metabolites)
atovaquone
pentamidine
metronidazole
paromomycin
Which of the following drugs does this MOA belong to? prodrug that undergoes deacetylation and reduction at the 5-nitro group, thought to inhibit the enzyme pyruvate:ferredoxin oxidoreductase disrupting the bioenergetics of the organism
nitazoxanide
paromomycin
chloroquine
quinine sulfate
Which of the following drugs does this MOA belong to? non absorbable oral aminoglycoside (binds 30S subunit of the ribosome), exists as 2 configurational isomers
nitazoxamide
paromomycin
mefloquine
chloroquine
Which of the following drugs does this MOA belong to? hemoglobin is digested by plasmodium in food vacuoles, releasing free heme (toxic to organism), which is polymerized to hemozoin. Bind to porphyrin nucleus of heme through pi-pi interactions with these aromatic rings, thus capping the polymerization reaction: heme remains free and poisons the plasmodium
4-substituted Quinolines (quinine, chloroquine, mefloquine, hemozoin)
primaquine
pyrimethamine
sulfadoxine
Which of the following drugs does this MOA belong to? unknown, progresses through a reactive oxygen species. Forms hydrogen peroxide, superoxides and hydroxy radicals that cause oxidative damage to critical cellular components of the parasite.
primaquine
pyrimethamine
sulfadoxine
artesunate
Which of the following drugs does this MOA belong to? potent inhibitor of dihydrofolate reductase (DHFR). Coadministered with sulfadoxine, which preferentially blocks plasmodium dihydrofolate synthesis, a "one-two-punch" in tetrahydrofolate synthesis
pyrimethamine
artesunate
chloroquine
primaquine
Which of the following drugs does this MOA belong to? as plasmodium degrades erythrocyte heme, the trioxane releases a reactive oxygen species that combines with the heme iron, creating a lethal Fe4=O species
artesunate
chloroquine
primaquine
These drugs have 2 MOAs. 1- bind tubulin and prevent +end from growing while -end continues to depolymerize; preferentially bind helminthic tubulin. 2- inhibit fumarate reductase; uncouples oxidative phosphorylation
albendazole
mebendazole
thiabendazole
ivermectin
praziquantel
Which of the following drugs does this MOA belong to? binds irreversibly to the glutamate-gated chloride channel of the nematode Haemonchus contortus, locking the channel open: paralyzes the worm
ivermectin
praziquantel
pyrantel pamoate
Which of the following drugs does this MOA belong to? affects calcium redistribution, drug leads to muscle contraction and paralysis. Affects phospoinositide metabolism, leading to paralysis.
praziquantel
ivermectin
pyrantel pamoate
Which of the following drugs does this MOA belong to? nicotinic receptor agonist: causing depolarization of neural tissue causing paralysis. inhibits cholinesterase
ivermectin
praziquantel
pyrantel pamoate
Choose the drugs that belong in the drug class Antiprotozoals
metronidazole, tinidazole
pentamidine
spiramycin
atovaquone
nitazoxanide
Choose the drugs that are in the class 4-Substituted Quinolines
quinine
chloroquine
mefloquine
primaquine
pyrimethamine
Choose the drugs that are in the class 8-aminoquinolines
primaquine
pyrimethamine
sulfadoxine
artesunate
Choose the drugs that are in the class Benzimidazoles
albendazole
mebendazole
thiabendazole
pyrantel pamoate
Choose the drugs that are in the class Antihelmintics
ivermectin
praziquantel
pyrantel pamoate
metronidazole
