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Med Chem Antiparasitics

Total questions: 36

Worksheet time: 24mins

Name
Class
Date
1.

Metronidazole acts against which bugs?

a)

amebiasis

b)

giardiasis

c)

anaerobic bacterial infections ie Clostridium difficile

d)

trichomoniasis

e)

toxoplasmosis

2.

Tinidazole acts against which bugs?

a)

trichomoniasis

b)

giardiasis

c)

amebiasis

d)

toxoplasmosis

e)

cryptosporidium

3.

Spiramycin acts against which bugs?

a)

toxoplasmosis

b)

cryptosporidium

c)

trypanosomes

d)

leishmaniasis

e)

malaria

4.

Pentamidine acts against which bugs?

a)

trypanosomes

b)

leishmaniasis

c)

malaria

d)

cryptosporidium

5.

Atovaquone acts against which bugs?

a)

trypanosomes

b)

leishmaniasis

c)

malaria

6.

Nitazoxanide acts against which bugs?

a)

cryptosporidium

b)

malaria

c)

leishmaniasis

d)

trypanosomes

7.

Paromomycin acts against which bugs?

a)

cryptosporidium

b)

trypanosomes

c)

leishmaniasis

d)

malaria

8.

Quinine Sulfate acts against which bugs?

a)

chloroquine-resistant plasmodium

b)

Plasmodium vivax

c)

Plasmodium ovale

d)

Plasmodium falciparum

9.

Primaquine acts against which bugs?

a)

Plasmodium vivax

b)

Plasmodium ovale

c)

Plasmodium falciparum

d)

chloroquine-resistant plasmodium

10.

Pyrimethamine acts against which bugs?

a)

used with quinine for chloroquine-resistant malaria

b)

trypanosome

c)

Plasmodium vivax

11.

Albendazole acts against which bugs?

a)

tapeworm

b)

whipworm

c)

roundworm

d)

threadworm

e)

hookworm

12.

Mebendazole acts against which bugs?

a)

roundworm

b)

hookworm

c)

pinworm

d)

whipworm

e)

threadworm

13.

Thiabendazole acts against which bugs?

a)

roundworm

b)

hookworm

c)

tapeworm

d)

whipworm

e)

threadworm

14.

Ivermectin acts against which bugs?

a)

Haemonchus contortus

b)

various common intestinal worms

c)

tapeworm

15.

Praziquantel acts against which bugs?

a)

cestodes

b)

trematodes

c)

nematodes

16.

Pyrantel Pamoate acts against which bugs?

a)

hookworm

b)

roundworm

c)

pinworm (drug of choice)

d)

tapeworm

e)

threadworm

17.

Which of the following are true?

a)

Metronidazole is a prodrug- nitro is reduced to hydroxylamine by organism, hydroxylamine allows for nonspecific binding

b)

Tinidazole has the same MOA as metronidazole

c)

Spiramycin is teratogenic which is why it is not FDA approved

18.

Which of the following drugs does this MOA belong to? Disruption of mitochondrial protein synthesis; concentrates in lungs, sinuses and female pelvic tissues; crosses placenta and distributes to breast milk

a)

Spiramycin

b)

Metronidazole

c)

Tinidazole

d)

Nitazoxamide

19.

Which of the following drugs does this MOA belong to? Prodrug; nitro is reduced to hydroxylamine by organism, hydroxylamine allows nonspecific binding to DNA, protein and membranes of organism

a)

metronidazole

b)

tinidazole

c)

atovaquone

d)

paromomycin

20.

Which of the following drugs does this MOA belong to? inhibits topoisomerase in P. carinii although MOA is thought to be different in different organisms (in trypanosoma: binds DNA)

a)

pentamidine

b)

atovaquone

c)

nitazoxanide

d)

paromomycin

21.

Which of the following drugs does this MOA belong to? ubiquinone reductase inhibitor (structural similarity to ubiquinone metabolites)

a)

atovaquone

b)

pentamidine

c)

metronidazole

d)

paromomycin

22.

Which of the following drugs does this MOA belong to? prodrug that undergoes deacetylation and reduction at the 5-nitro group, thought to inhibit the enzyme pyruvate:ferredoxin oxidoreductase disrupting the bioenergetics of the organism

a)

nitazoxanide

b)

paromomycin

c)

chloroquine

d)

quinine sulfate

23.

Which of the following drugs does this MOA belong to? non absorbable oral aminoglycoside (binds 30S subunit of the ribosome), exists as 2 configurational isomers

a)

nitazoxamide

b)

paromomycin

c)

mefloquine

d)

chloroquine

24.

Which of the following drugs does this MOA belong to? hemoglobin is digested by plasmodium in food vacuoles, releasing free heme (toxic to organism), which is polymerized to hemozoin. Bind to porphyrin nucleus of heme through pi-pi interactions with these aromatic rings, thus capping the polymerization reaction: heme remains free and poisons the plasmodium

a)

4-substituted Quinolines (quinine, chloroquine, mefloquine, hemozoin)

b)

primaquine

c)

pyrimethamine

d)

sulfadoxine

25.

Which of the following drugs does this MOA belong to? unknown, progresses through a reactive oxygen species. Forms hydrogen peroxide, superoxides and hydroxy radicals that cause oxidative damage to critical cellular components of the parasite.

a)

primaquine

b)

pyrimethamine

c)

sulfadoxine

d)

artesunate

26.

Which of the following drugs does this MOA belong to? potent inhibitor of dihydrofolate reductase (DHFR). Coadministered with sulfadoxine, which preferentially blocks plasmodium dihydrofolate synthesis, a "one-two-punch" in tetrahydrofolate synthesis

a)

pyrimethamine

b)

artesunate

c)

chloroquine

d)

primaquine

27.

Which of the following drugs does this MOA belong to? as plasmodium degrades erythrocyte heme, the trioxane releases a reactive oxygen species that combines with the heme iron, creating a lethal Fe4=O species

a)

artesunate

b)

chloroquine

c)

primaquine

28.

These drugs have 2 MOAs. 1- bind tubulin and prevent +end from growing while -end continues to depolymerize; preferentially bind helminthic tubulin. 2- inhibit fumarate reductase; uncouples oxidative phosphorylation

a)

albendazole

b)

mebendazole

c)

thiabendazole

d)

ivermectin

e)

praziquantel

29.

Which of the following drugs does this MOA belong to? binds irreversibly to the glutamate-gated chloride channel of the nematode Haemonchus contortus, locking the channel open: paralyzes the worm

a)

ivermectin

b)

praziquantel

c)

pyrantel pamoate

30.

Which of the following drugs does this MOA belong to? affects calcium redistribution, drug leads to muscle contraction and paralysis. Affects phospoinositide metabolism, leading to paralysis.

a)

praziquantel

b)

ivermectin

c)

pyrantel pamoate

31.

Which of the following drugs does this MOA belong to? nicotinic receptor agonist: causing depolarization of neural tissue causing paralysis. inhibits cholinesterase

a)

ivermectin

b)

praziquantel

c)

pyrantel pamoate

32.

Choose the drugs that belong in the drug class Antiprotozoals

a)

metronidazole, tinidazole

b)

pentamidine

c)

spiramycin

d)

atovaquone

e)

nitazoxanide

33.

Choose the drugs that are in the class 4-Substituted Quinolines

a)

quinine

b)

chloroquine

c)

mefloquine

d)

primaquine

e)

pyrimethamine

34.

Choose the drugs that are in the class 8-aminoquinolines

a)

primaquine

b)

pyrimethamine

c)

sulfadoxine

d)

artesunate

35.

Choose the drugs that are in the class Benzimidazoles

a)

albendazole

b)

mebendazole

c)

thiabendazole

d)

pyrantel pamoate

36.

Choose the drugs that are in the class Antihelmintics

a)

ivermectin

b)

praziquantel

c)

pyrantel pamoate

d)

metronidazole