WorksheetsImmunosuppressive Drugs
Total questions: 15
Worksheet time: 13mins
Which of the following conditions will benefit from immunosuppresive drugs?
Corneal transplant
Dermatomyositis
Anaemia
Crohn's disease
How do immunosuppresive drugs benefit patients following organ transplantation?
They prevent rejection of the transplanted organ.
They prevent a headache, which is common occurrence following organ transplantation.
They kill bacteria that may be introduced during the transplantation.
They prevent the development of cancer following the transplantation.
By logical inference, do you think immunosuppressive drugs increase the risk for suffering from an infection?
Yes
No
Prednisone has immunosuppressant properties.
True
False
Which of these immunosuppressant does not bind to cyclophilin and inhibit calcineurin?
Cyclosporine
Neomycin
Tacrolimus
Patients with AIDS should be routinely treated with immunosuppressive drugs.
True
False
Vaccines have an immunosuppressant effect.
True
False
Cyclosporine can damage the kidneys.
True
False
Alemtuzumab is a biological agent that acts as an immunosuppressant.
True
False
The intensity of immunosuppressive treatment during the induction phase of treatment is usually lower than in the maintenance phase.
True
False
A patient on immunosuppressive therapy is given tacrolimus as part of their drug regimen. Which side effect is most likely to occur with this drug?
Hypoglycaemia
Hypokalaemia
Profound myelosuppression
Renal toxicity
There are several general principles that must be considered when designing an immunosuppressive drug regimen for a patient undergoing an organ transplant. Which of the following is a side effect common to all immunosuppressant drugs that limit the dosages that can safely be used for long term maintenance therapy?
Hypertension
Hip fractures
Increased risk of infections and neoplasia
Osteoporosis
One of the drugs that Mr Ali took to suppress organ rejection was azathioprine. Which of the following describes its mechanism of action?
Blockade of leukocyte adhesion to endothelial cells.
Conversion to 6 mercaptopurine, a purine antimetabolite toxic to stimulated lymphocytes.
Decreased prostaglandin production due to inhibition of phospholipase A2.
Inhibition of TNF-alpha.
A prodrug that is converted to a metabolite that is a selective inhibitor of inosine monophosphate dehydrogenase, and is a selective inhibitor of lymphocyte proliferation. It can be combined with cyclosporine in kidney, liver and heart transplants. It has relatively minimal toxicity apart from some GI effects.
Azathioprine
Cyclophosphorine
Mycophenolate mofetil
Methotrexate
Which of the following statements is FALSE?
Tacrolimus inhibits the calcineurin pathway.
Steroids bind to cytosolic receptors and heat shock proteins.
Mycophenolate inhibits purine synthesis via GMP dehydrogenase.
Sirolimus will block kinase in the IL-2 receptor pathway.
