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HEMATOLOGY 2 PREFINAL EXAMINATION

Total questions: 50

Worksheet time: 26mins

Name
Class
Date
1.

What deficiency causes gray platelet syndrome?

a)

dense granule deficiency

b)

alpha granule deficiency

c)

combined dense and alpha granule deficiencies

d)

platelet cyclo-oxygenase deficiency

2.

The following coagulation studies were obtained:

Bleeding time=3 min

Platelets =350 x 103/uL

Platelet adhesiveness=Normal

APTT=45.0 sec

APTT= 32.0 sec

Factor VIII= 5%

These results would most likely indicate:

a)

classic hemophilia

b)

Christmas disease

c)

Hageman factor deficiency

d)

Immune thrombocytopenic purpura

3.

Which of the following platelet responses is most likely associated with hemophilia A (Factor VIII deficiency)?

a)

defective ADP release; normal response to ADP

b)

decreased amount of ADP in platelets

c)

absent aggregation to epinephrine, ADP, and collagen

d)

normal platelet aggregation

4.

Which of the following platelet responses is most likely associated with Glanzmann's thrombasthenia?

a)

decreased platelet aggregation to ristocetin

b)

defective ADP release; normal response to ADP

c)

decreased amount of ADP in platelets

d)

markedly decreased aggregation to epinephrine, ADP, and collagen

5.

The APTT:

a)

tests the extrinsic coagulation pathway

b)

monitors Coumadin therapy

c)

requires tissue thromboplastin

d)

monitors heparin therapy

6.

In the APTT test, the patient's plasma is mixed with:

a)

ADP and calcium

b)

tissue thromboplastin and collagen

c)

phospholipid and calcium

d)

tissue thromboplastin and calcium

7.

A bleeding time is used to evaluate the activity of:

a)

platelets

b)

prothrombin

c)

labile factor

d)

Factor XIII

8.

A patient with a severe decrease in factor X activity

would demonstrate normal

a)

aPTT

b)

PT

c)

thrombin time

d)

bleeding time

9.

Fibrinogen is converted to fibrin monomers by

a)

prothrombin

b)

thrombin

c)

calcium ions

d)

factor XIIIa

10.

Prothrombin to thrombin conversion is accelerated by

a)

a complex of activated factors IX and VII

b)

factor V and ionized calcium

c)

a complex of phospholipids and factor VII

d)

complex of activated factors X and V

11.

Which of the following platelet responses is most likely associated with classic von Willebrand's disease?

a)

decreased platelet aggregation to ristocetin

b)

normal platelet aggregation to ristocetin

c)

absent aggregation to epinephrine, ADP, and collagen

d)

decreased amount of ADP in platelets

12.

Which of the following is the most common cause of an abnormality in hemostasis?

a)

decreased plasma fibrinogen level

b)

decreased Factor VIII level

c)

decreased Factor IX level

d)

quantitative abnormality of platelets

13.

Which of the following is characteristic of Bernard-Soulier syndrome

a)

giant platelets

b)

normal bleeding time

c)

abnormal aggregation with ADP

d)

increased platelet count

14.

Which of the following is a characteristic of cellular changes as megakaryoblast mature as megakaryocytes within the bone marrow?

a)

progressive decrease in overall cell size

b)

increasing basophils of cytoplasm

c)

nuclear division without cytoplasmic division

d)

fusion of nuclear lobes

15.

Which of the following cells is largest in the bone marrow?

a)

Histiocyte

b)

Monocyte

c)

Megakaryocyte

d)

Mast cells

16.

The combination of increased capillary fragility and prolonged bleeding time suggests a deficiency in:

a)

Thromboplastin

b)

Prothrombin

c)

Platelets

d)

Fibrinogen

17.

Platelet activity is affected by:

a)

Calcium

b)

Aspirin

c)

Hyperglycemia

d)

Hypoglycemia

18.

Alpha granules are found on the platelet in:

a)

Peripheral zone

b)

Sol gel zone

c)

Organelle zone

d)

Membrane Systems

19.

Thrombocytopenia is a characteristic of:

a)

Classic vWD

b)

Hemophilia A

c)

Glanzmann thrombasthenia

d)

May-Hegglin anomaly

20.

The preferred product for a bleeding patient with Type I vWD is?

a)

Factor II, VII, IX, X concentrates

b)

Platelet concentrates

c)

FFP and platelets

d)

Cryoprepitated AHF

21.

Platelet aggregation will occur with the end production of:

a)

cyclooxygenase

b)

arachidonic acid

c)

prostacyclin

d)

Thromboxane A2

22.

The 2 factors that differentiate liver disease from Vitamin K deficiency are:

a)

II and VII

b)

IX and VII

c)

VIII and IX

d)

V and VIII

23.

Hemophilia B is a sex-linked recessive disorder that presents with a decrease in Factor:

a)

VIII

b)

IX

c)

X

d)

XI

24.

Low molecular weight heparin is monitored by a:

a)

Anti-Xa assay

b)

APTT

c)

PT

d)

Anti-II a assay

e)

Bleeding time

25.

How many stages of Hemostasis?

a)

1

b)

2

c)

3

d)

4

26.

Which antocoagulants is used in hemostasis test?

a)

Sodium Citrate

b)

Sodium Fluoride

c)

Lithium Heparin

d)

EDTA K3

27.

Which of the following substances is found in

the dense granules of platelets?

a)

Platelet-derived Growth Factor

b)

von Willebrand factor

c)

Serotonin

d)

Fibrinogen

28.

Which of the following statements is correct regarding the platelet membrane?

a)

The lipid layer is comprised mainly of phospholipids

b)

Thrombin facilitates binding to sub-endothelium

c)

Platelet phospholipid facilitates binding of Factor XII

d)

Thromboxane is made from membrane glycoproteins

29.

Which of the following substances promotes platelet activation?

a)

Protein S

b)

Prostacyclin

c)

Nitric Oxide

d)

ADP

30.

The exposure of tissue factor to blood starts which process?

a)

platelet adhesion

b)

platelet aggregation

c)

the coagulation cascade

d)

vasoconstriction

31.

What is the name of the soluble factor that results in fibrinolysis?

a)

plasmin

b)

tissue plasminogen activator

c)

fibrin degradation product

d)

alpha 2 antiplasmin

32.

Which pathway is represented by the diagram shown?

a)

Extrinsic pathway

b)

Intrinsic pathway

c)

Common pathway

d)

none of the above

33.

Which of the following clotting factors are activated by thrombin? Select all that apply

a)

Factor V

b)

Factor X

c)

Factor XIII

d)

Factor XI

34.

Which of the following is the platelet receptor for platelet adhesion?

a)

GP IIb/IIIa

b)

vWF

c)

GP Ib

d)

actin

35.
Which factors are involved in the initial activation of the coagulation system and require contact with a negatively charged surface for their activation?
a)
II, V, VII, and X
b)
XII, XI, PK, and HK
c)
II, VII, IX, and X
d)
I, V, VIII, and XIII
36.

Which of the following is not involved in the fibrinolytic system?

a)

plasminogen activator inhibitors

b)

plasmin

c)

FXII, kallikrein

d)

FXa

37.

Vasoconstriction

a)

the wound is “corked”, or covered with sticky platelets

b)

blood vessels constrict (or “shrink”) to slow blood flow at the site of injury

c)

Formation of a Fibrin Blood Clot

d)

All except A

e)

All except B

38.

In this Hemostasis step, platelets attach to exposed damaged wall of blood vessels which platelets become irregular, larger and stick to each other to form soft mass

a)

Vascular spasm

b)

Platelet plug formation

c)

Coagulation

d)

Scab formation

39.

A localized clotted mass of blood found in an organ, tissue or space. It is caused by a traumatic injury, such as a blow, that can cause a blood vessel to rupture

a)

Sickle Cell Anemia

b)

Hematoma

c)

Septicemia

d)

Aneurysm

40.

A hereditary disease in which the blood clots slowly or abnormally. This causes prolonged bleeding with even minor cuts and bumps

a)

Anemia

b)

Hemophilia

c)

Embolism

d)

Atherosclerosis

41.

Chemicals that are used to dissolve a clot like plasminogen activator, streptokinase:

a)

Thrombolytic agens

b)

Anticoagulants

c)

Aspirin

d)

Blood thinners

42.

Chemicals that prevent clot formation like heparin, warfarin, EDTA are called

a)

Thrombolytic agens

b)

Anticoagulants

c)

Aspirin

d)

Blood Thinners

43.

What are the steps in platelet plug formation

a)

aggregation, adhesion, activation, secretion

b)

adhesion, activation, secretion, aggregation

c)

secretion, adhesion, activation, aggregation

d)

adhesion, secretion, activation, aggregation

44.

Fibrinogen interacts with which of the following receptors?

a)

GPIb/IX

b)

GP X

c)

GB IIb/IIIa

d)

GP V!b

45.
What plays a role in platelet activation?
a)
Fibrinolysis
b)
Endothelium
c)
Platelets
d)
Collagen
46.
TTP stands for Thrombotic throbocytopenic purpura. Which of these is something that would NOT be a result of this disease.
a)
consumption of platelets
b)
purple-colored areas in the skin
c)
hypercirculation
d)
hypocirculation
47.
Which of the following is an acquired disorder?
a)
Hemophilia
b)
Glanzmann's Thrombasthenia
c)
Bernard-Soulier Syndrome
d)
Vitamin K Deficiency
48.
Jim has always had a problem with excessive bleeding and after cutting his finger while cooking, and it the bleeding lasting much longer than it should have, he decides to see a doctor about the issue. The doctor said Jim's platelets are forming clots in his blood vessels and this causes him to have a low platelet count in the rest of his body. What disease does Jim have?
a)
Bernard-Soulier Syndrome
b)
Glanzmann's Thrombasthenia
c)
Hemophilia
d)
TTP
49.

How many coagulation factors are there?

a)

12

b)

15

c)

14

d)

13

50.
Low platelet adhesion is a symptom of which disorder?
a)
Hemophilia
b)
Von Willebrand's disease
c)
TTP
d)
Aspirin ingestion

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