WorksheetsTherapeutic Management of COVID-19 (CHH)
Total questions: 20
Worksheet time: 22mins
All of the following are possible signs and symptoms of an individual with MILD COVID-19 except:
Pneumonia
Fever
Dry Cough
Anosmia
Which of the following statements is true?
WHO recommends the use of remdesivir in hospitalized patients with severe COVID-19.
IDSA recommends against the use of remdesivir in hospitalized patients regardless of disease severity.
Studies show that favipiravir is safe for use in known or suspected pregnancy.
None of the statements are true.
True or False. Tocilizumab is recommended in hospitalized adults with progressive severe or critical COVID-19 infection and those who have elevated markers of systemic inflammation.
True
False
What happens to a COVID-19 infected patient with hyperinflammatory syndrome?
Interleukin-6 elevation
Cytokine storm
Acute Respiratory Distress Syndrome (ARDS)
All of the above
Why is it important to regularly monitor the glucose levels of patients taking dexamethasone? Please answer in 1-2 sentences. (Bonus question - 2 points)
Which of the following is false about leronlimab?
It is an investigational IgG4 monoclonal antibody that blocks CCR5.
The first patient to use leronlimab in the Philippines, under CSP, died from COVID-19.
It was granted by the Philippine FDA a Compassionate Special Permit to treat COVID-19.
It is currently in Phase 2b/3 clinical trials for 390 severely ill COVID-19 patients in the USA.
The following statements are true for patients with COVID-19 except:
Patients infected with COVID-19 have been associated with inflammation and a prothrombotic state.
Patients with COVID-19 can have a normal WBC count.
All patients infected with COVID-19 experience the same signs and symptoms.
Patients with critical COVID-19 may have septic shock, encephalopathy, heart failure and spetic shock.
Patient A, 20 years old, is currently completing his quarantine in a hotel for COVID-19 patients. He has no known co-morbidities. Based on the NIH COVID-19 Treatment Guidelines, should he be given Enoxaparin for the prevention of VTE or arterial thrombosis?
Yes.
No.
Patient B, 35 years of age, is hospitalized for COVID-19. She is diagnosed with hypertension and Type II Diabetes Mellitus. Based on the NIH COVID-19 Treatment Guidelines, should she receive a prophylactic dose of anticoagulation therapy?
Yes.
No
True or False. According to the NIH COVID-19 Treatment Guidelines, there is sufficient data to recommend the use of Vitamin C as treatment in noncritical and critical COVID-19 patients.
True
False
This drug is commonly used as a first-line agent to sedate intubated COVID-19 patients with ARDS in the ICU.
Famotidine
Propofol
Tocilizumab
Dexamethasone
First choice vasopressor for acute resuscitation of patients with COVID-19.
Epinephrine
Dobutamine
Norepinephrine
Amiodarone
What is the mechanism of action of Pfizer's Novel Oral Antiviral agent?
Interleukin-6 Receptor Antagonist
H1-receptor antagonist
H2-receptor antagonist
Protease inhibitor
According to pharmacokinetic and pharmacodynamic studies, what is the dose required for ivermectin to achieve the plasma concentrations necessary for the antiviral efficacy detected in vitro?
50-fold higher than those approved for use in humans
100-fold higher than those approved for use in humans
200 mcg/kg PO once as a single dose, THEN repeat dose once in 7 days
200 mcg/kg as single dose; may repeat in 14 days if necessary
What is the maximum daily dose of Paracetamol administered orally?
3.5 grams
5 grams
4 grams
2 grams
The following are reasons why enoxaparin is preferred over oral anticoagulants, except:
Shorter half-life
Can be administered IV or SQ
Longer half-life
Have fewer drug-drug interactions
True or False. The first CSP patient of leronlimab in the Philippines was detached from high-flow oxygen and was breathing on his own after 35 hours of one dose of 700mg leronlimab SQ.
True
False
The following statements are true about colchicine, except:
Colchicine is an anti-inflammatory drug.
It can reduce the chemotaxis of neutrophils and inhibit inflammasome signaling.
There is insufficient data to either recommend for or against the use of colchicine in nonhospitalized patients with COVID-19.
NIH recommends the use of colchicine in hospitalized patients.
Which of the statements is true about severe COVID-19?
Chest imaging is normal.
Clinical signs of non-severe pneumonia.
SpO2 of less than or equal to 92%
None of the above.
All are markers of inflammation, except:
CRP
IL-6
LDH
None of the above
