WorksheetsDISEASES OF THE BLOOD ISMART QUIZ (02 AUGUST 2021)
Total questions: 20
Worksheet time: 20mins
Which of the following viruses is more likely to be associated with chronic immune thrombocytopenia?
Cytomegalovirus
Parvovirus
Influenza virus
Human immune deficiency virus
In hemophilia A, factor VIII level activity should be increased to 100% in
Iliopsoas bleeding
Tooth extraction
Hematuria
Gum bleeding
You are evaluating a 7-year-old male child with cervical lymphadenopathy, the MOST likely finding that raise your suspicion of malignancy is
Fluctuant nodes
Fixed nodes
Presence of systemic symptoms
No regression in the size of the nodes to its normal within 2 weeks
A 5-year-old male child develops hematoma and bruising of his left hand next day after falling on the floor; the mother stated that her child has a poor wound healing and a history of delayed umbilical separation during the neonatal period. Of the following, the MOST valuable test for this case is
Bleeding time
Partial thromboplastin time
Thrombin time
Clot solubility test
Of the following, the least likely feature of acute immune thrombocytopenia (ITP)
Preceding viral infection
Mucocutaneous bleeding
Isolated splenomegaly
Increased number of megakaryocytes in the bone marrow
Which of the following children with acute immune thrombocytopenia is MOST likely to have a benefit from splenectomy?
An 8-year-old girl with multiple bruises and platelets count of 10,000/ml
A 6-year-old boy with mild epistaxis and platelets count of 20,000/ml
A 4-year-old boy with subdural hematoma and platelets count of 100,000/ml after receiving IVIG
A 9-year-old boy with severe rectal bleeding and platelets count of 20000/ml not responding to medical treatment
Thirty-six to 48 hours after the initiation of iron therapy, the following is seen in a patient with iron-deficiency anemia:
Erythroid hyperplasia
Reticulocytosis
Increase in hemoglobin level
Increase in mean corpuscular volume
The main reason behind irradiation of the blood products is to prevent
Transfusion-related bacterial infections
Transfusion-related viral infections
Transfusion-related acute lung injury (TRALI)
Graft-versus-host disease (GVHD)
The physiologic anemia of infancy is a form of adaptation to extrauterine life. The suppression of erythropoiesis is brought about by the downregulation in the production of the following variable:
Fetal hemoglobin
Oxygen
Carbon dioxide
Erythropoietin
Older children have sufficient vitamin B12 stores to last 3 to 5 years. The physiologic requirement for vitamin B12 is about what level:
0.1-0.3 ug/day
0.5-0.6 ug/day
0.7-0.8 ug/day
1-3 ug/day
When the diagnosis of folate deficiency is established, folic acid may be administered at the following dose:
0.1 mg/day
0.8 mg/day
2 mg/day
3 mg/day
Which of the following indicators is elevated in iron-deficiency anemia?
Transferrin saturation
Serum ferritin
Serum transferrin
Hepcidin
Which of the following clinical and laboratory findings is not suggestive of hemolytic type of anemia:
Splenomegaly
Reticulocytosis
Tea-colored urine
Direct hyperbilirubinemia
The laboratory finding that has been suggested as a screening test for hereditary spherocytosis combined with RBC distribution width (RDW) < 14% is
High reticulocytes count of more than 10%
Normal mean corpuscular volume (MCV)
High mean corpuscular hemoglobin concentration (MCHC)
Indirect hyperbilirubinemia
The diagnostic test of choice for paroxysmal nocturnal hemoglobinuria (PNH) is
Acidified serum hemolysis (HAM) test
Sucrose lysis test
Flow cytometry
Bone marrow study
The best indicator of total body iron stores for patients with thalassemia major is achieved by
Liver MRI
Bone marrow biopsy
Serum ferritin
Total iron binding capacity
The physiologic anemia of infancy is a form of adaptation to extrauterine life. The suppression of erythropoiesis is brought about by the downregulation in the production of the following variable:
Fetal hemoglobin
Oxygen
Carbon dioxide
Erythropoietin
The most specific test that is helps distinguish congenital red blood cell (RBC) aplasia from acquired transient erythroblastopenia of childhood
Hemoglobin electrophoresis
Reticulocyte count
Erythrocyte adenosine deaminase (ADA) enzyme level assay
Mean corpuscular volume (MCV)
The mainstay of therapy for congenital hypoplastic anemia is
Corticosteroids
Androgen
Antithymocyte globulin (ATG)
Fully matched-related stem cell transplantation
A very high RBC distribution width (RDW) is most likely consistent with
Iron deficiency anemia
Sideroblastic anemia
Thalassemia
Sickle cell anemia
