Which plasma protein system results in activation of inflammatory cells and contributes to bronchoconstriction?

In the complement system, C3a functions mainly as:

Which of the following is NOT one of the cardinal signs of inflammation?

Which plasma protein system results in the direct lysis of bacterial membranes by a protein complex?

Which individual likely has the most functional immune system?

Which component of the complement system forms part of the membrane lysis complex?

Which of the following represents the innate immune system's first line of defense ?

Which of the following is a characteristic of system symptoms of inflammation as opposed to local symtpoms?

Opsonization is a process by which the immune system "tags" a foreign microbe allowing macrophages to find and phagocytize it. Which of the following products of the complement system acts as an opsonin?

Which of the following types of hypersensitivity produces a delayed reaction due to the development of memory T cells?

In this type of hypersensitivity reaction specific cells or tissue are recognized as antigen and most of the damage is related to the activity of tissue macrophages.

Which of the following types of hypersensitivity can result in skin reactions? (SELECT ALL THAT APPLY)

Circulating complexes of soluble antigen and IgG/IgM deposit in tissue, activate complement, and initiate damage by neutrophils occurs in:

Which of the following correctly pairs hypersensitivity type with symtoms/disease?

The role of histamine is most prevalent in which type of hypersensitivity reaction?

Which type of hypersensitivity reaction is mediated by IgE?

Which of the following immunoglobulin is predominantly found in normal body secretions?

The central lymphoid organ for B lymphocytes is the:

Which immunoglobulin is the predominant antibody produced upon SECONDARY exposure?

At which site does clonal selection occur?

Which type of immunity is produced by an individual after transfusion of donor antibodies in IVIG? (IV administration of donor IgG)

Which of the following secrete antibodies?

Which of the following blood group is considered the "universal donor"?

A disturbance in the immunologic tolerance of self-antigens is referred to as:

SLE is an example of:

Hemolytic anemia of the newborn is most likely in which of the following scenarios?

altered immunologic response to an antigen that results in disease or damage to the host

an exaggerated response against/hypersensitivity to an environmental antigen

directed against beneficial foreign tissues (ex: transfusions, transplants)

immunity is insufficient to protect the host

Cell is destroyed by antibodies and complement [mechanism of type II reactions]

antibody causes cell destruction through phagocytosis by macrophages [mechanisms of type II reactions]

Antibody and complement attract neutrophils [mechanisms of type II reactions]

Antibody-dependent cell-mediated cytotoxicity (ADCC) [mechanisms of type II reactions]

Causes target cell to malfunction (not destroyed) [mechanisms of type II reactions]

IgE mediated

effector cells: mast cells

Complement is involved? No

Rate of development? Immediate

seasonal allergic rhinitis

Initial Phase of Type I hypersensitivity reactions

Late Phase of type I hypersensitivity reactions:

tissue-specific

IgG, IgM

effector cells: macrophages and neutrophils

Complement is involved? Frequently

autoimmune thrombocytopenic purpura, autoimmune hemolytic anemia, graves disease

TB skin test

immune-complex mediated

effector cells: only neutrophils

SLE

Tissue damage associated w Type III reaction is due to

cell-mediated

rate of development? delayed

No immunoglobulins

contact sensitivity to poison ivy and metals

atopic dermatitis

contact dermatitis

locally acting secreted immunoglobulins

low concentration in blood; are surface receptors on developing B lymphocytes

immunoglobulins that mediate allergic response

substance released by damaged cells that activates coagulation

enzyme that degrades fibrin polymers in clots

eliminate virus-infected cells

release chemicals that initiate the inflammatory response

type of chemical barrier

chemicals involved in the inflammatory response

antibodies and antigens [complement system]

mannose-containing bacterial carbohydrates [complement system]

gram-negative bacterial and fungal cell wall polysaccharides [complement system]

Emily, age 6, has an infected finger and has just been given an antibiotic. Her mother is very worried because the finger is red and swollen. After a nurse tells her these signs will go away as the infection and inflammation resolves, Emily's mother asks, "Isn't inflammation really bad for you?". She needs to know that inflammation does what?

A new nurse asks, "why is fever associated with inflammation? what causes it?" choose the best response.

neonate does not develop an infection bc he has maternal antibodies that he received in breastmilk

child does not develop an infection bc she has been immunized against it

man does not develop an infection bc he was infected with that same microorganism previously and recovered

woman does not develop an infection bc she was given gamma globulin after being exposed to an infected person

child develops systemic anaphylaxis after eating peanut butter

adult develops rejection of a transplanted heart

adult develops rash on legs from poison ivy after hiking in shorts

adult develops hemolysis after mismatched blood transfusion

adolescent develops systemic anaphylaxis after being stung by a wasp