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Worksheets

Path - Heme/Onc

Total questions: 34

Worksheet time: 18mins

Name
Class
Date
1.

Macrophages phagocytize senescent RBC at which primary location? (Riggs quiz)

a)

spleen

b)

thymus

c)

bone marrow

2.

The enzyme that directly degrades fibrin is: (Riggs quiz)

a)

tissue plasminogen factor (t-PA)

b)

plasmin

c)

urokinase-like plasminogen activator (u-PA)

d)

plasminogen

3.

What happens to iron that is in red blood cells broken down by macrophages? (Riggs quiz)

a)

excreted in the bile

b)

broken down into amino acids

c)

recycled

d)

excreted by the kidneys

4.

A deficiency in thrombopoeitin will lead to: (Riggs quiz)

a)

Anemia

b)

Thrombocytosis

c)

Thrombocytopenia

d)

Polycythemia vera

5.

Site of hematopoeisis in adults occurs: (Riggs quiz)

a)

liver

b)

distal long bones

c)

axial skeleton

d)

spleen

6.

Which of the following cells is the least differentiated? (Riggs quiz)

a)

T lymphocyte

b)

hematopoetic stem cell

c)

common lymphoid progenitor

d)

common myeloid progenitor

7.

The enzyme in the blood that directly converts fibrinogen to fibrin: (Riggs quiz)

a)

factor Xa

b)

thrombin

c)

von Willebrand factor

d)

tissue factor

8.

A deficiency in erythropoietin will result in: (Riggs quiz)

a)

anemia

b)

thrombocytosis

c)

polycythemia vera thrombocytopenia

d)

thrombocytopenia

9.

Which of the following results in platelet activation/adhesion? (Riggs quiz)

a)

heparin

b)

fibrinogen

c)

tissue factor

d)

von Willebrand factor

10.

The most numerous granulocytes that serve as chief phagocytes in early inflammation (Riggs quiz)

a)

basophils

b)

eosinophils

c)

neutrophils

d)

mast cells

11.

Which of the following are agranuloctyes? (select all that apply) (Riggs quiz)

a)

Mast cells

b)

Monocytes

c)

NK cells

d)

Lymphocytes

12.

Erythropoietin is secreted by _____ when oxygen levels get too _______. (Riggs quiz)

a)

the kidney; low

b)

bone marrow; high

c)

bone marrow; low

d)

the kidney; high

13.

The hormone that controls iron storage is: (Riggs quiz)

a)

erythropoeitin

b)

tissue factor

c)

thrombopoeitin

d)

hepcidin

14.

Which of the following does not differentiate from the common myeloid progenitor? (Riggs quiz)

a)

NK cell

b)

platelets

c)

erythrocytes

d)

T cells

15.

Stored iron is depleted in long standing iron deficiency anemia. (Riggs quiz)

a)

True

b)

False

16.

Which hemolytic dysfunction is consistent with a leukemia? (Riggs quiz)

a)

thrombocythemia

b)

relative polycythemia

c)

hemochromatosis

d)

polycythemia vera (primary polycythemia)

17.

Erythrocytes that are described with the term "anisocytosis" means the RBCs are: (Riggs quiz)

a)

assuming various sizes

b)

are bite cells

c)

assuming various shapes

d)

assuming low hemoglobin

18.

Anemia that is classified as normocytic and normochromic is likely due to: (Riggs quiz)

a)

Iron deficiency

b)

B12 deficiency

c)

Hemorrhagic blood loss

d)

Folate deficiency

19.

Hypocellular bone marrow replaced with fat is a characteristic lesion of: (Riggs quiz)

a)

aplastic anemia

b)

iron deficiency anemia

c)

hemolytic anemia

d)

hemochromatosis

20.

Which of the following can result in anemia? (SELECT ALL THAT APPLY) (Riggs quiz)

a)

Reduction the number of circulating WBCs

b)

Reduction in the total number of RBCs

c)

Reduction in the quantity of hemoglobin in RBCS

d)

Reduction in the number of circulating platelets

21.

Stored iron is depleted in long standing anemia of chronic disease. (Riggs quiz)

a)

True

b)

False

22.

Elevated homocysteine and a mutated MTHFR gene suggest which type of anemia? (Riggs quiz)

a)

folate deficiency

b)

hemolytic

c)

anemia of chronic disease

d)

iron deficiency

23.

Treatment with erythropoietin (EPO) is beneficial in which type of anemia? (Riggs quiz)

a)

pernicious anemia

b)

iron deficiency anemia

c)

anemia due to acute blood loss as a result of trauma

d)

anemia of chronic disease due to kidney disease

24.

Which of the following does not contribute to the hyperdynamic state caused by anemia? (Riggs quiz)

a)

dilation of blood vessels

b)

decreased blood viscosity

c)

increased peripheral resistance

d)

increased stroke volume

25.

White blood cell counts higher than normal: (Riggs quiz)

a)

leukopenia

b)

neutropenia

c)

anemia

d)

leukocytosis

26.

Which of the following has a rapid progression based on disease categorization? (Select all that apply) (Riggs quiz)

a)

Chronic myelogenous leukemia

b)

Acute myelogenous leukemia

c)

Chronic lymphocytic leukemia

d)

Acute lymphocytic leukemia

27.

The incidence of leukemia increases with age except for the following type: (Riggs quiz)

a)

AML

b)

CML

c)

ALL

d)

CLL

28.

Match the viral pathogen and the target cell involved in infectious mononucleosis. (Riggs quiz)

a)

Epstein-Barr virus; B lymphocytes

b)

Epstein-Barr virus; T lymphocytes

c)

Adenovirus; T lymphocytes

d)

Adenovirus; B lymphocytes

29.

Which of the following derives from the common myeloid progenitor cell? (Riggs quiz)

a)

Burkitt Lymphoma

b)

Acute basophilic leukemia

c)

Multiple Myeloma

d)

Lymphoblastic lymphoma

30.

Granulocytopenia is defined as: (Riggs quiz)

a)

severe neutropenia

b)

complete absence of granulocytes

c)

increased circulating eosinophils

d)

decreased circulating basophils

31.

Increased circulating lymphocytes could be found in which of the following situations? (Riggs quiz)

a)

Lymphoma

b)

Chronic infections

c)

Leukemia

d)

All answers are correct

32.

Lymphoma is most often found in which primary location? (Riggs practice quiz)

a)

Bone marrow

b)

Blood

c)

Lymphs

d)

Kidneys

33.

Which of the following the primary clinical presentations is specific to Burkitt lymphoma that is diagnosed in US children? (Riggs practice quiz)

a)

Jaw mass

b)

Abdominal swelling

c)

Anemia

d)

Fever

34.

Which of the following is true about Hodgkin lymphoma? (Riggs practice quiz)

a)

Extent of disease is rarely localized

b)

Fever, night sweats, and weight loss are common

c)

Reed Sternberg cells are absent

d)

It involves multiple peripheral nodes

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