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WorksheetsNeurotransmitters
Total questions: 13
Worksheet time: 7mins
In order to relieve depression, psychiatrists may attempt to prevent destruction of neurotransmitters. Monoamine oxidase (MAO) affects levels of tyramine, a neurotransmitter which acts as a hypertensive agent in brain. Therefore, to avoid vascular accidents in the brain, persons who are prescribed MAO are advised to avoid tyramine-containing foods such as pickled foods. Monoamine oxidase relieves depression by ……………….
Decreasing reuptake of catecholamines
Blocking degradation of catecholamines
Blocking reuptake of monoamine neurotransmitters
Blocking degradation of monoamine neurotransmitters
Enhancing transport of catecholamine neurotransmitters
Which of the followings is a reason that is it is difficult to prove that amino acids can function as neurotransmitters?
They can be released from nerve terminals.
Postsynaptic receptor activation by application of amino acids can excite or inhibit neurons.
They are found within glial cells.
They play a role in protein synthesis for all nerve cells.
They are found within few cells of the brain.
A person with a known genetic defects of monoamine neurotransmitter disorders went in for a scheduled checkup. Cerebrospinal fluid test showed elevated levels of 5-HTP and L-DOPA, but low levels of HVA and 5-HIAA. The most likely molecular defect in this patient is in which one of the following enzymes?
Pteridine reductase
Dopamine hydroxylase
Tyrosine hydroxylase
Tryptophan hydroxylase
Aromatic amino acid decarboxylase
A soldier who suffering from nerve gas exposure (such as sarin) is given atropine to counteract the effects. How does atropine work against nerve gas?
It will bind to nerve gas and help inactivate.
It will compete with nerve gas for binding to acetylcholine receptors.
It could induce overproduction of acetylcholine receptors to cover amount of nerve gas.
It will inactivate acetylcholine esterase and allow more acetylcholine to cross the synaptic cleft.
It binds acetylcholine receptor which blocks the excess acetylcholine remaining in the synaptic cleft.
The administration of L-DOPA, which is given in the treatment of Parkinson disease, bypasses the rate-limiting enzyme of catecholamine biosynthesis. What is the name of this rate-limiting enzyme?
Dopamine β-hydroxylase
Glutamate decarboxylase
Phenylalanine hydroxylase
Tryptophan hydroxylase
Tyrosine hydroxylase
Which of the following neurotransmitters, by acting as a retrograde messenger, has a role in maintaining smooth muscle relaxation, increasing blood flow to the penis, and thereby maintaining erection?
Serotonin
Glutamate
Nitric oxide
Acetylcholine
Norepinephrine
Membrane carrier proteins are NOT required for ………………
amino acid transport through the membrane.
simple diffusion.
facilitated diffusion.
active transport.
K+ accumulation by the cell.
Which of the followings causes neurotransmitters to accumulate at synaptic cleft by increase in neurotransmitters release?
Eserine
Cocaine
Pargyline
Strychnine
Black widow spider venom
Neuropeptides are present in synaptic terminals because they are …………
Synthesized in the terminal.
Carried by fast axonal transport.
Carried by diffusion.
Carried by slow axonal transport.
Taken-up from the extracellular space.
Glutamate up-take into glial cells ...................
is a dead-end pathway.
is by passive diffusion.
results in its metabolism into glutamine by glutaminase.
results in its metabolism into glutamine by glutamine synthase.
results in its metabolism into GABA by glutamic acid decarboxylase.
NMDA receptors .............
require membrane depolarization to permit ion flow.
require membrane depolarization to permit ion flow and are NOT permeable to Ca2+.
are NOT permeable to Na+.
bind to G-proteins.
have seven-membrane spanning structure consisting of a single subunit.
GABA and glycine produce inhibitory responses by .............
opening ion channels permeable to K+.
opening ion channels permeable to Na+.
opening ion channels permeable to Cl-.
binding to G-protein coupled receptors.
closing ion channels permeable to K+ permeability occurs.
Which of the following is an ionotropic receptor?
The muscarinic receptor
The glycine receptor
The guanylyl cyclase
The enkephalin receptor
The adenosine receptor
