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WorksheetsEXAM 2 BMS PDA STUDY GUIDE Part 1
Total questions: 166
Worksheet time: 1hrs 28mins
Sugars are Poly-alcohols where the second to last carbon is in the _____________ conformation.
Right Handed (D)
Left Handed (L)
The reference compound for naming D and L isomers of sugars is:
Fructose
Glucose
Glyceraldehyde
Ribose
Sucrose
What is this sugar?
Erythrose
Ribose
Glyceraldehyde
Glucose
Mannose
What is this sugar?
Erythrose
Glucose
Galactose
Ribose
Glyceraldehyde
What is this Sugar?
Galactose
Glucose
Mannose
Ribose
Erythrose
Which of the following structures is Glucose?
Which of the following structures is Mannose?
Which of the following structures is Galactose?
Which of the following is an epimeric pair?
D-Glucose and D-Glucosamine
D-Glucose and D-Mannose
D-Glucose and L-Glucose
D-Lactose and D-Sucrose
L-Mannose and L-Fructose
Which of these is Dihydroxyacetone?
Which of the following structures is Fructose?
Which of the following monosaccharides is not an aldose?
Erythrose
Fructose
Glucose
Glyceraldehyde
Ribose
When the linear form of glucose cyclizes, the product is a(n):
anhydride
glycoside
hemiacetal
lactone
Oligosaccharide
The alpha-D-Glucopyranose has the OH _____ of the first carbon.
Up
Left
Down
Right
The beta-D-Glucopyranose has the OH _____ of the first carbon.
Down
Left
Right
Up
Which of the following is an anomeric pair?
D-glucose and D-fructose
alpha-D-glucose and beta-D-glucose
D-glucose and L-Glucose
alpha-D-glucose and beta-L-glucose
Which of the following is a reducing sugar?
Glucose
Starch
Cellulose
Sucrose
Which of the following is not a reducing sugar?
Fructose
Glyceraldehyde
Ribose
Sucrose
What is the common feature of a D-sugar?
The second carbon has the -OH group on the left side
The second carbon has the -OH group on the right side
The second to last carbon has the -OH group on the left side
The second to last carbon has the -OH group on the right side
D-Glucose is called a reducing sugar because it undergoes an oxidation-reduction reaction at the anomeric carbon. One of the products of this reaction is:
D-galactose
D-gluconate
D-glucuronate
D-ribose
Which of the following is a reduced glucose? (draw them to answer this question)
fructose
galactose
gluconate
glucitol
Which of the following monosaccharides is not a carboxylic acid? (draw them to answer this question)
6-phospho-gluconate
gluconate
glucose
glucuronate
Muramic acid
What is the name of this molecule?
galactosamine
glucanate
glucitol
glucosamine
Trehalose
Glc (alpha 1 --> 1 alpha)
Glc (alpha 1 --> 4) Glc
Glc (alpha 1 --> 2 beta) Fru
Gal (beta 1 --> 4) Glc
Maltose
Gla (alpha 1 --> 1 alpha) Glc
Glc (alpha 1 --> 4) Glc
Glc (alpha 1 --> 2 beta) Fru
Gal (beta 1 --> 4) Glc
Sucrose
Glc (alpha 1 --> 1 alpha) Glc
Glc (alpha 1--> 4) Glc
Glc (alpha 1--> 2 beta) Fru
Gal (beta 1 --> 4) Glc
Lactose
Glc (alpha 1 --> 1 alpha) Glc
Glc (alpha 1 --> 4) Glc
Glc (alpha 1 -->2 beta) Fru
Gal (beta 1 --> 4) Glc
Glc (linked by alpha 1-4 bonds)
Glycogen
Chitin
Cellulose
Amylose
Amylopectin
Glc (linked by alpha 1-4 bonds) with alpha 1-6 branch points - made in animals
Amylose
Glycogen
Chitin
Cellulose
Amylopectin
GalNAc (linked by beta 1-4 bonds)
Amylose
Cellulose
Glycogen
Amylopectin
Chitin
Glc (linked by beta 1-4 bonds)
Cellulose
Amylose
Amylopectin
Glycogen
Chitin
Glc (linked by alpha 1-4 bonds) with alpha 1-6 branch points - made in plants
Glycogen
Chitin
Amylose
Amylopectin
Cellulose
Glycogen is a heteropolysaccharide.
True
False
Glycan is a heteropolysaccharide.
True
False
Glycogen is a:
homopolysaccharide
disaccharide
glycan
monosaccharide
Sucrose is a(n):
glycan
monosaccharide
homopolysaccharide
disaccharide
Chondroitin sulfate is a(n):
disaccharide
homopolysaccharide
glycan
monosaccharide
Mannose is a(n):
glycan
Monosaccharide
disaccharide
homopolysaccharide
Which blood type has an extra GalNAc compared to type O?
Type A Blood Antigen
Type B Blood Antigen
Which blood type has an extra Gal compared to type O?
Type A Blood Antigen
Type B Blood Antigen
Which of the following is a heteropolysaccharide?
Cellulose
Chitin
Hyaluroante
Glycogen
Starch
Which of the following co-enzymes and/or vitamins are needed for pyruvate decarboxylase?
lipoic acid
niacin
panthothenic acid (as Co-enzyme A)
riboflavin
thiamine
Starting with glucose and going to 2 pyruvates, how many net ATP were produced?
2
4
6
10
Starting with glucose and going to 2 pyruvates, how many net NADH were produced?
2
4
6
10
2 pyruvates to 2 Acetyl-CoA produce _____ CO2 and _____ NADH.
2, 4
4, 4
4, 2
2, 2
2, 6
2 isocitrates to 2 alpha-ketoglutarates produce _____ CO2 and _____ NADH.
4, 2
2, 2
6, 2
2, 4
Starting with 1 six carbon glucose, up to this point a total of ____ ATP, ____ CO2 and ____ NADH have been produced.
2, 4, 6
6, 2, 4
4, 2, 6
2, 6, 4
In alpha-keto-glutarate dehydrogenase, 2 alpha-ketoglutarates to 2 succinyl-CoA's Produce ___ CO2 and ___ NADH
2, 4
6, 4
2, 6
2, 2
In alpha-keto-glutarate dehydrogenase: Starting with 1 six carbon glucose, up to this point, a total of ___ ATP, ___CO2 and ___ NADH have been produced.
2, 2, 4
8, 6, 2
2, 4, 6
2, 6, 8
2 succinyl-CoA's to 2 succinates produce ___ GTP and ___ CoA's
2, 4
2, 2
1, 2
2, 6
Starting with 1 six carbon glucose, up to this point, a total of ___ ATP, ___ GTP, ___ CO2 and ___ NADH have been produced.
2, 2, 6, 8
2, 6, 2, 8
6, 8, 2, 2
8, 2, 6, 2
Succinate Dehydrogenase: 2 succinates to 2 fumarates produce ___ FADH2
4
2
6
8
Succinate Dehydrogenase: Starting with 1 six carbon glucose up to this point a total of ___ ATP, ___ GTP, ___ CO2, ___ FADH2 and ___ NADH have been produced.
2, 6, 2, 2, 8
8, 2, 2, 6, 2
2, 2, 6, 2, 8
2, 8, 2, 6, 2
Malate Dehydrogenase: 2 malates to 2 oxaloacetates produce: ___ NADH
1
2
4
6
Malate Dehydrogenase: Starting with 1 six carbon glucose, up to this point a total of ___ ATP, ___ GTP, ___ CO2, ___ FADH2, and ___ NADH have been produced.
2, 2, 6, 2, 2,
2, 4, 6, 2, 2
2, 2, 6, 2, 10
2, 6, 6, 4, 2
If we convert all GTP to ATP, how does the following change? Starting with 1 six carbon glucose, up to this point a total of ___ ATP, ___ CO2, ___ FADH2, and ___ NADH have been produced
6, 2, 4, 8
2, 3, 2, 5
2, 2, 4, 6
4, 6, 2, 10
ETC will convert FADH2 into 1.5 ATP and NADH into 2.5 ATP.
Starting with 1 six carbon glucose, up to this point a total of up to ____ ATP, and ___ CO2 are produced.
(a)
When ATP is high in a cell, how does this affect the CAC?
the CAC slows down
No effect
the CAC speeds up
Which of the following lists of CAC intermediates is in the correct order?
pyruvate, acetyl-CoA, citrate, isocitrate, alpha-ketoglutarate, succinyl-CoA, fumarate, succinate, malate, oxaloacetate
pyruvate, citrate, acetyl-CoA, isocitrate, succinyl-CoA, alpha-ketoglutarate, succinate, fumarate, malate, oxaloacetate
pyruvate, acetyl-CoA, citrate, isocitrate, alpha-ketoglutarate, succinyl-CoA, succinate, fumarate, malate, oxaloacetate
pyruvate, succinyl-CoA, citrate, isocitrate, alpha-ketoglutarate, acetyl-CoA, succinate, fumarate, malate, oxaloacetate
Which of the following lists of enzymes of the CAC are in the correct order?
pyruvate dehydrogenase, citrate synthase, aconitase, isocitrate dehydrogenase, alpha-keto-glutarate dehydrogenase, succinate dehydrogenase, succinyl-CoA synthetase, fumarase, malate dehydrogenase
pyruvate dehydrogenase, citrate synthase, aconitase, isocitrate dehydrogenase, alpha-keto-glutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase, malate dehydrogenase
pyruvate dehydrogenase, citrate synthase, aconitase, alpha-keto-glutarate dehydrogenase, isocitrate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase, malate dehydrogenase
pyruvate dehydrogenase, citrate synthase, aconitase, isocitrate dehydrogenase, alpha-keto-glutarate dehydrogenase, fumarase, succinyl-CoA synthetase, succinate dehydrogenase, malate dehydrogenase
What reduced molecule is oxidized at site I?
ATP
FAD
NADH
FADH2
Which of the following toxins are known to inhibit site I?
Cyanide
DNP
oligomycin
rotenone
What class of drugs are known to inhibit the synthesis of Ubiquinone?
steroids
statins
sulfonylureas
beta-blockers
Which of the following is an inhibitor for site II?
Rotenone
Cyanide
Malonate
Antimycin A
What drug is known to inhibit site III?
Antimycin A
DNP
Oligomycin
Rotenone
Site 4 is inhibited by:
Antimycin A
Cyanide
DNP
rotenone
Which of the following is a Proton Gradient Uncoupling agent?
atractyloside
Dinitrophenol
Oligomycin
Antimycin A
ATP/ADP antiporter inhibitor:
rotenone
Dinitrophenol
cyanide
atractyloside
ATP synthase inhibitor:
Antimycin A
Oligomycin
Atractyloside
rotenone
What is the ultimate electron acceptor?
Fe3+
O2
CO2
K+
If a fatty acid has a double bond, what is the configuration of that double bond?
trans
D
cis
L
Last carbon of a fatty acid is referred to as:
Omega
Carbon #3
Beta
Alpha
Carbon that is 2 carbons away from the carboxylic carbon is referred to as:
alpha
Carbon #2
Beta
Carbon #1
Which of the following is an unsaturated fatty acid?
C16:0
C18:0
C16:1
C20:0
Which of the following is an Omega-3-Fatty acid?
C20:4
C18:1
C18:3
C16:0
Which of the following is an Omega-6-Fatty acid?
C20:4
C16:0
C18:1
C18:3
Which of the following is an Omega-9-Fatty Acid
C18:3
C16:0
C18:1
C20:4
Which of the following is a saturated fatty acid?
C18:3
C20:4
C18:1
C16:0
What functional groups connects the fatty acids to the glycerol?
(a)
Glycerol can be described as:
ketone
Poly alcohol
peptide
reduced sugar
hemiacetal
Which of the following decreases the fluidity of a fat?
increasing the temperature
increasing the length of fatty acids
increasing the number of double bonds
What is Olestra?
amino acids held together by peptide bonds
a polymer of glucose
fatty acids esterified to glycerol
fatty acids esterified to sucrose
a fatty acid esterified to cholesterol
What is Olestra?
a drug that blocks the digestion of triglycerides
a low calorie fat substitute
a drug that blocks the digestion of starch
a low calorie sugar substitute
a drug to lower cholesterol
What is the difference between storage fat and membrane lipid?
Membrane lipids are phosphodiglycerides while storage fat are triglycerides
Membrane lipids are triglycerides while storage fat are phosphodiglycerides
Which of the following structures would you find on a phosphodiglyceride?
a polar head group
a ketone group
glycerol esterified to 2 fatty acids
phosphate esterified to glycerol
unsaturated fatty acid esterified to glycerol
Which functional group change do you find on a plasmalogen compared to a phosphodiglyceride?
an ether at position 2 rather than an ester
an ether at position 1 rather than an ester
Which of the following is similar to a diglyceride, but has a carbon-carbon bond at position 1 and an amide at position 2?
plasmalogen
olestra
sphingolipid
diglyceride
Which of the following is similar to a diglyceride but has an ether at position 1?
Plasmalogen
olestra
sphingolipid
triglyceride
Which of the following has 6 fatty acids esterified to sucrose?
plasmalogen
sphingolipid
phosphodiglyceride
Olestra
Which of the following has 2 fatty acids esterified to glycerol with phosphate esterified on the 3rd position?
olestra
phosphodiglyceride
diglyceride
triglyceride
Which of the following is 2 fatty acids esterified to glycerol?
sphingolipid
diglyceride
plasmalogen
triglyceride
Which of the following has 3 fatty acids esterified to glycerol?
triglyceride
diglyceride
sphingolipid
olestra
What type of molecule is a blood group antigen?
proteoglycan
glycolipid
glycoprotein
a phosphodiglyceride
Glycolipids are oligosaccharide sugars which are usually attached to which type of lipid?
cholesterol
fatty acid
sphingolipid
phosphodiglyceride
Which of the following blood types has an extra Galactose N Acetate (GalNAc)?
Type A
Type B
Type O
Which of the following blood types has an extra Galactose (Gal)?
Type A
Type B
Type O
Which blood type has one less monosaccharide compared to the other two types?
Type A
Type B
Type O
Defects of the beta-galactosidase enzyme causes which disease?
Gaucher's disease
Tay-Sachs disease
generalized gangliosidosis
Fabry's disease
Defects of the glucocerebrosidase enzyme causes which disease?
Gaucher's disease
Niemann-Pick disease
Fabry's disease
Tay Sachs disease
Defects of the hexosaminisases A and B enzyme causes which disease?
Tay-Sachs disease
Fabry's disease
Gaucher's disease
Sandhoff's disease
Defects of the hexosaminidase A enzyme causes which disease?
Gaucher's disease
Tay-Sachs disease
generalized gangliosidosis
Niemann-Pick disease
Defects of the alpha-galactosidase A enzyme causes which disease?
Niemann-Pick disease
Fabry's disease
generalized gangliosidosis
Standhoff's disease
Defects of the spingomyelinase enzyme causes which disease?
Sandhoff's disease
Fabry's disease
Niemann-Pick disease
Gaucher's disease
Which following disease results in failure to place a mannose-6-phosphate on to a lysosomal glycoprotein enzyme?
Tay Sachs disease
I-cell disease
generalized gangliosidosis
Gaucher's disease
Which of the following diseases results in a defect in hexamidase A?
Tay Sachs disease
I-cell disease
generalized gangliosidosis
gaucher's disease
Which of the following diseases results in a defect in beta-galactosidase?
I-Cell disease
Tay Sachs disease
Gaucher's disease
generalized gangliosidosis
Which of the following diseases results in a defect in glucocerebrosidase?
I-cell disease
Gaucher's disease
Tay Sachs Disease
Generalized gangliosidosis
Which of the following molecules is made from cholesterol? (pick all that apply)
Cortisol
Vitamin E
Estrogen
Testosterone
Vitamin D
Which of the following has 5 carbons?
CoQ10
isoprenoid
Vitamin D
Rickets
Which of the following has 10 isoprene units?
Cholesterol
Vitamin D
CoQ10
Isoprenoid
Which of the following is made from cholesterol?
Vitamin D
Isoprenoid
CoQ10
Rickets
Which of the following results in a Vitamin D deficiency?
Rickets
Cholesterol
CoQ10
Isoprenoid
Which of the following has 4 fused rings?
Isoprenoid
Vitamin D
Cholesterol
CoQ10
At which stage of the cell cycle does Cell Division take place?
M
S
G1
G0
At which stage of the cell cycle does DNA replication take place?
M
G2
G1
S
At which stage of the cell cycle is the cell so highly specialized that it can no longer be divided?
G2
G-TD
S
G0
At which point of the cell cycle is protein synthesis needed for DNA replication?
G1
G2
S
M
At which point of the cell cycle is protein synthesis needed for cell division?
G1
S
G2
M
At which point of the cell cycle is the cell not growing or preparing for division?
G0
G2
S
M
What is a molecule needed to progress from one stage to the next?
(a)
Which is a part of the cell cycle that prevents movement to the next stage of the cell cycle unless a requirement is met?
(a)
Which cyclin is needed for the movement from G1 to S?
Cyclin A-CDK2
Cyclin B-CDK2
Cyclin E-CDK2
Which molecule blocks Cyclin E-CDK2?
p53 via p21
Vitamin E
Zymogen
People with a mutation of p53 are at risk for which of the following?
diabetes
cancer
ulcers
obesity
A sequence of events resulting from a cell's inappropriate entry into mitosis resulting in apoptosis is referred to as a:
(a)
(a) inhibits the action of cyclin allowing for DNA repair or apoptosis
Which of the following choices represent the correct order of the cell cycle?
G1, M, S, G2
S, G1, G2, M
G1, S, M, G2
G1, S, G2, M
Which of the following are in the correct order?
Prophase, Metaphase, Prometaphase, Anaphase, Telophase
Prophase, Prometaphase, Metaphase, Anaphase, Telophase
Prophase, Prometaphase, Metaphase, Telophase, Anaphase
Prometaphase, Prophase, Metaphase, Telophase, Anaphase
At which stage does the nuclear envelope disintegrate?
Prophase
Prometaphase
Metaphase
Anaphase
At which stage do the chromosomes condense?
Prophase
Metaphase
Anaphase
Telophase
At which stage does the DNA move to an equatorial region of the cell?
Anaphase
Telophase
Metaphase
Prometaphase
At which stage does the DNA pairs separate?
Prophase
Prometaphase
Telophase
Anaphase
At which stage does the cell divide?
Telophase
Prometaphase
Anaphase
Prophase
Programmed cell death is referred to as:
(a)
Which of the following is a regulatory protein in the cascade of insulin and insulin-like growth factors?
Gain of function mutation
Ras
proto-oncogene
oncogene
Which of the following is a mutation to a regulatory protein which causes it to have increased function?
Gain-of-Function Mutation
Ras
oncogene
proto-oncogene
Which of the following is a normal gene which, when altered by a mutation, becomes an oncogene?
Ras
Gain-of-Function mutation
Oncogene
Proto-oncogene
Which of the following is a gene that has the potential to cause cancer?
proto-oncogene
Gain-of-Function mutation
Ras
Oncogene
If solute X requires active transport to move into the cell and solute Y uses passive transport to enter the cell, where are X and Y at higher concentrations?
X - Outside, Y - Inside
X - Inside, Y - Inside
X - Inside, Y - Outside
X - Outside, Y - Outside
If solute Y leaves the cell in exchange for Na+ entry, and solute X enters the cell when an "X" channel opens, where are X and Y at higher concentrations?
X - Outside, Y - Outside
X - Inside, Y - Outside
X - Outside, Y - Inside
X - Inside, Y - Inside
Calculate the Nernst potential for K+ under the following conditions:
Intracellular K+: 150mM and Extracellular K+: 2mM
114mV
63mV
-114mV
-63mV
Lipids in a membrane can move quickly in which way?
into the cytoplasm
lateral diffusion on one side of the membrane
flip-flop diffusion from one side to the other
into the extracellular matrix
Which of the following factors Increase membrane fluidity?
a decrease in temperature
an increase in the amount of unsaturation
an increase in the length of the fatty tails
Which of the following statements about membranes is true?
most plasma membranes contains more than 70% protein
steroids are found in membranes
Membranes consist of a single layer of lipids
free fatty acids make up most of the membrane surface
Which of the following is a protein in bedded into a membrane?
serpentine proteins
peripheral proteins
integral proteins
transmembrane proteins
Which of the following are proteins that pass through a membrane multiple times?
Integral proteins
peripheral proteins
serpentine proteins
transmembrane proteins
Which of the following are proteins attached to a membrane, but the amino acids don't penetrate the membrane?
integral proteins
transmembrane proteins
serpentine proteins
peripheral proteins
Which of the following are integral proteins that pass all the way through a protein?
transmembrane proteins
peripheral proteins
serpentine proteins
integral proteins
A protein channel permits specific ions to passively (no input of energy) pass through a membrane.
ionophore
simple diffusion
ion channel
facilitated diffusion
A protein channel permits specific molecules or ions to pass through a membrane, but requires the input of energy, usually in the form of ATP.
facilitated diffusion
Secondary active transport
simple diffusion
Primary active transport
Molecules can dissolve into and back out of the membrane.
ion channel
simple diffusion
secondary active transport
facilitated diffusion
A molecule that can bind to an ion and then dissolve into and across a membrane.
ion channel
ionophore
secondary active transport
simple diffusion
A protein channel permits specific molecules or ions to pass through a membrane, but requires the input of energy from an ion gradient.
primary active transport
ion channel
facilitated diffusion
secondary active transport
A protein channel permits specific molecules to passively (no input of energy) pass through a membrane.
facilitated diffusion
primary active transport
simple diffusion
secondary active transport
Which molecule is needed to facilitate the movement of water into and out of a cell to balance osmolarity on both sides of the membrane
(a)
Uses ATP to pump protons (H+) out and potassiums in, needed to acidify the stomach lumen
P type of ATPase of the plasma membrane of eukaryotes
F type of ATPase of the mitochondria
V type of ATPase of the vesicles
P type of ATPase of the plasma membrane of the stomach parietal cells
Uses ATP to pump 3 sodiums out and 2 potassiums in, needed to polarize a cell
V type of ATPase of the vesicles
P type of ATPase of the plasma membrane of eukaryotes
F type of ATPase of the mitochondria
P type of ATPase of the plasma membrane of the stomach parietal cells
Is primary active transport running in reverse to make ATP from a proton gradient
F type of ATPase of the mitochondria
P type of ATPase of the plasma membrane of eukaryotes
F type of ATPase of the mitochondria
P type of ATPase of the plasma membrane of the stomach parietal cells
Uses ATP to pump protons (H+) into the vesicle
P type of ATPase of the plasma membrane of the stomach parietal cells
F type of ATPase of the mitochondria
V type of ATPase of the vesicles
P type of ATPase of the plasma membrane of eukaryotes
Secondary active transport found on the luminal side of intestinal cells
Glucose Sodium Symporters
GluT 1 Transporters
GluT 4 Transporters
GluT 3 Transporters
Facilitated glucose transporters that are insulin sensitive and found on muscle and fat cells
GluT 5 Transporters
Glucose Sodium Symporters
GluT 4 Transporters
GluT 3 Transporters
N-type Acetyl Choline Receptor Inhibitor
Saxitoxin
Vanadate
Curare
Ouabian
Sodium-Potassium ATPase Inhibitor
Ouabain
Curare
Tetrodotoxin
Vanadate
Voltage-gated sodium channel Inhibitor (from red tide bacteria)
Tetrodotoxin
Ouabain
Saxitoxin
Vanadate
Voltage-gated sodium channel inhibitor (from puffer fish)
Curare
Ouabain
Saxitoxin
Tetrodotoxin
P-type ATPase Inhibitor
Ouabain
Vanadate
Saxitoxin
Curare
