WorksheetsObetohep
Total questions: 20
Worksheet time: 10mins
Liver is second largest organ in human body?
TRUE
False
Main functions of liver are-
Bile production
Metabolism of fats, proteins, and carbohydrates
Storage of glycogen, vitamins, and minerals
Synthesis of plasma proteins, such as albumin, and clotting factors
All of the above
Bile is made up of____________.
bile acids
cholesterol & phospholipids
bile pigments (bilirubin and biliverdin)
electrolytes and water
All of the above
Bile acid is produced by _________________.
enterocytes
hepatocytes
parietal cells
None of the above
Nonalcoholic fatty liver disease (NAFLD) is an umbrella term for a range of liver conditions affecting people who drink little to no alcohol.
True
False
NAFLD is-
too much fat stored in liver cells.
too much bile stored in liver cells.
too much proteins stored in liver cells.
All of the above
Primary Biliary Cholangitis(PBC) is a chronic progressive autoimmune disease?
TRUE
FALSE
Progression of Primary Biliary Cholangitis includes-
destruction of small bile ducts of liver
bile build up in liver
cholestasis
permanent liver scarring (cirrhosis)
All of the above
Obeticholic Acid (OCA) is a semi-synthetic analog of bile acid chenodeoxycholic acid (CA) ?
TRUE
FALSE
OCA (Obeticholic Acid) is ____________ more potent than CA.
10 times (approx.)
50 times (approx.)
100 times (approx.)
1000 times (approx.)
Obeticholic acid is a potent farnesoid X receptor (FXR) agonist ?
TRUE
FALSE
FXR (farnesoid X receptor) are found in __________.
liver
intestine
Both of the above
None of the above
Obeticholic acid acts by_____________.
Inhibiting bile acid synthesis
Increasing bile acid clearance to reduce hepatic exposure to bile acids
Reduction of overall bile acid pool
Protects liver from toxic effects of accumulation of bile acids
All of the above
OCA offers OD dose advantage Vs BD dosage of UDCA?
TRUE
FASLE
Half life of Obeticholic acid is______.
4 Hrs.
24 Hrs.
48 Hrs.
4 days
Excretion of Obeticholic acid is mainly fecal > 85%?
TRUE
FALSE
As per Regenerate trial with OCA "Better improvement in fibrosis by at least 1 stage without worsening was observed". ?
TRUE
FALSE
Obetohep (OCA) is indicated for treatment of PBC (DCGI/USFDA)?
TRUE
FALSE
What is the average weight decrease by OCA in NASH Patients?
2.3 kg
3.2 kg
2.3 gm
23 kg
Most Patients move from ________________ to________________ fibrosis after treatment with OCA.
Severe to advance
Moderate to Advance
Advance to Moderate
