WorksheetsCoagulation Final Review
Total questions: 40
Worksheet time: 13mins
What is the circulating lifespan of platelets?
2-3 days
5-6 days
9-10 days
120 days
ADP, serotonin and calcium are released from which type of granules?
Dense
Alpha
Beta
Gamma
What factor is responsible for platelet adhesion?
von Willebrand's Factor
Tissue Factor
Fibrinogen
Thrombin
What proportion of platelets are in the circulating blood?
30%
50%
70%
100%
When a vessel contracts in response to damage, what is it called?
Vasodilation
Vasoconstriction
The peripheral zone of the platelet has a fluffy outer coating called _.
The membrane
Open canalicular system
Dense tubular system
Glycocalyx
If a blue top specimen is only half full, how would that affect coagulation testing?
Shorten
Unaffected
Prolonged
The platelet receptor for fibrinogen is _.
Thromboxane A2
Platelet Factor 3
GPIb
GPIIb/IIIa
Platelet aggregation refers to platelets binding to_.
the vessel wall
epithelial cells
other platelets
smooth muscle
What stages are involved in hemostasis?
Platelet Plug Formation
Fibrin Clot Formation
Fibrinolysis
All of the Above
Factors II, VII, IX, and X are:
in the intrinsic pathway
vitamin K dependent
made in the bone marrow
unaffected by heparin
Factors XII, XI, HMWK, and PK belong to which group of factors?
Contact
Prothrombin
Fibrinogen
All of the Above
What is the inactive form of a coagulation factor called?
Kininogen
Bradykinin
Plasmin
Zymogen
Where are the coagulation factors produced?
Kidney
Liver
Spleen
Bone Marrow
What is the process of breaking down a fibrin clot into soluble fragments called?
Fibrinolysis
Hemostasis
Coagulation
Inflammation
What protein is the driving force of fibrinolysis?
Fibrin
Thrombin
Plasmin
D-Dimer
What is the common name for Factor IX?
Christmas Factor
von Willebrand's Factor
Hageman Factor
Calcium
Which factor activates the extrinsic pathway?
Thrombin
Fibrin
Tissue Factor
Hageman Factor
The common name for factor VI is:
Christmas Factor
Fitzgerald Factor
Stuart-Prower Factor
None of the Above
Which test monitors the extrinsic pathway?
PT
PTT
Thrombin Time
D-Dimer
What are small, pinpoint lesions <3mm called?
Petechiae
Purpura
Ecchymosis
Thrombus
This type of ITP develops shortly after a viral infection in children.
Acute
Chronic
Bernard Soulier Syndrome has a normal platelet aggregation response to:
ADP, collagen, epinephrine
Ristocetin
von Willebrand's and Bernard Soulier Syndrome are disorders of platelet:
Secretion
Aggregation
Adhesion
What disease state is associated with agranular platelets?
Defective Thromboxane A2 Synthesis
Gray Platelet Syndrome
Scott Syndrome
Storage Pool Disease
A splenectomy will cause the platelet count to be:
Increased
Decreased
Normal
Which two disease states are microangiopathic hemolytic anemias?
Acute ITP and HUS
Chronic ITP and TTP
TTP and HUS
Acute and Chronic ITP
ADP, epinephrine, collagen, and ristocetin are used in what test?
Bleeding Time
PT
PTT
Platelet Aggregation Studies
Which of the following is a disorder of platelet aggregation?
Bernard Soulier Syndrome
Glanzmann's Thrombasthenia
von Willebrand's Disease
Storage Pool Disease
TTP and HUS are disease that result from thrombi developing within the blood vessels.
True
False
Which test is useful for monitoring thrombolytic drugs such as streptokinase?
PTT
FDP and D-DImer
Bleeding Time
PT
Which result would be abnormal in Hemophilia A?
PT
Platelet count
Factor VIII: vWF activity
Factor VIII activity
Which anticoagulant alters the synthesis of Vitamin K dependent factors?
Coumadin
Heparin
Aspirin
Ibuprofen
What is the minimum amount of factor activity need to produce a normal PT and PTT?
30%
50%
70%
100%
Which factor deficiency has an abnormal PT, but not a normal PTT?
II
VII
IX
X
What test monitors heparin therapy?
PT
Bleeding Time
PTT
Platelet Aggregation
Factor V Leiden mutation resists the action of:
Thrombin
Plasmin
Antithrombin III
Protein C and Protein S
DIC is associated with:
Schistocytes
Positive D-Dimer
Prolonged PT, PTT
All of the Above
A mixing study does not correct the results of a PTT. What does this indicate?
Circulating Inhibitor
Factor Deficiency
Thrombolytic agents are designed to:
Inhibit Factors XII and XI
Inhibit Thromboxane A2
Prevent Platelet Aggregation
Activate Plasmin
