WorksheetsBlood Glucose Regulation
Total questions: 15
Worksheet time: 11mins
Hyperglycemic hormones are:
Insulin
Thyroxine
Epinephrine
Growth hormone
Glucagon
Choose the causes of hypoglycemia
Tumors
Extreme starvation
Diabetes mellitus
Natural metabolic response to illness
Exercise vigorously
Effects of insulin:
Stimulates liver glycogen synthase
Stimulates glycolysis
Inhibit pyruvate carboxylase
Inhibits glucokinase
Inhibits uptake of glucose in muscle and adipose tissue
Liver is the most important organ in maintaining blood glucose level because:
It takes up glucose from blood by depending on insulin
Liver does not have glucose-6-phosphatase
Liver can stock glucose as glycogen or breakdown stored glycogen
Liver stores glycogen in the form of glucose
Hormonal control of glucose homeostasis main target organ involved are:
Pancreas
Liver
Muscle
Adipose tissue
Kidney
Choose the false statement
Cortisol hormone increases gene expression of phosphoenolpyruvate carboxykinase (PEPCK)
Body can get glucose from glycerol
Insulin activates glycogen phosphorylase
Growth hormone counteracts the effects of insulin
Epinephrine increases glucagon secretion
Thyroid hormone:
Stimulates glycogen synthesis
Increases catabolism of protein
Stimulates gluconeogenesis
Increases lipolysis
Inhibit glycogen breakdown
Choose any correct any correct answers about Humoral control
Law of mass action
Lactate activate PFK-1
Allosteric regulations of metabolic pathway
Fructose 2,6- bisphosphate inhibits PFK-1
Glucose-6-phosphate activates hexokinase
When insulin/glucagon ratio is high,
Causes dephosphorylation of PFK-2
Causes decreased cAMP
Decreases protein kinase A activity
FBP-2 is inactive
Increases rate of glycolysis
All of the following are true about glucagon except:
Stimulate gluconeogenesis
Inhibit PFK-1
Reduce expression of phosphoenolpyruvate carboxykinase
Inhibit pyruvate kinase
Reduce glycolysis
What are the sources of glucose?
Glycogen stores in liver and muscle
Fructose
Amino Acids
Glycerol
Glycogenolysis
Why glucose is so important?
Energy source for the brain
Raw materials or the intermediates of various metabolic pathway
Energy source for exercising muscle
Energy source for cells with no mitochondria
State the normal blood glucose level (Fasting plasma glucose)
(a)
Insulin promotes translocation of GLUT (a) from intracellular vesicles to the cell membrane.
High glucagon/insulin ratio:
Increases protein kinase A activity
Decreases level of fructose 2,6-bisphosphate
Decrease inhibition of FBPase-1
Increases rate of gluconeogenesis
Causes phosphorylation of PFK-2
