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Worksheets

Week 7 MCB Tutoring

Total questions: 15

Worksheet time: 9mins

Name
Class
Date
1.

From a molecular biology perspective, what is the cause of Cystic Fibrosis?

a)

Improper clathrin-pit formation

b)

Defective cotranslational translocation

c)

Incorrect protein folding

d)

Excessive N-linked glycosylation

2.

Which of the following describes the flow of proteins through the Golgi apparatus?

a)

cis-Golgi to Golgi stack to trans-Golgi

b)

cis-Golgi to trans-Golgi to Golgi stack

c)

Golgi stack to cis-Golgi to trans-Golgi

d)

Golgi stack to trans-Golgi to cis-Golgi

e)

Trans-Golgi to Golgi stack to cis-Golgi

3.

What is the likely fate of a free-floating protein without a molecular tag located in the Golgi apparatus?

a)

Cytosolic protein

b)

Golgi apparatus protein

c)

Lysosomal protein

d)

Membrane protein

e)

Secretory protein

4.

A male infant is born with bilateral dislocated hips, restricted shoulder and elbow joints, cloudy corneas, and course facial features. Which of the following is the location of the dysfunctional enzyme responsible for the most likely diagnosis in this patient?

a)

Endosomes

b)

Proteasome

c)

Golgi apparatus

d)

RER

e)

SER

5.

You walk into the ER and encounter a peculiar patient. The patient complains of neck stiffness, dysphagia, and lockjaw. The patient states they stepped on a rusty nail, but thought nothing of it. Chances are this patient was exposed to the ____ toxin, which degraded ____.

a)

Tetanus / synaptobrevin

b)

Tetanus / syntaxin

c)

Botulin / synaptobrevin

d)

Botulin / syntaxin

6.

A molecule of glucose is needing entry into a cell. Which class of plasma membrane protein would grant access for this molecule?

a)

Membrane channel

b)

Transporter

c)

Receptor

d)

Gap junction

7.

A patient presents to the clinic with feelings of fatigue, weakness, and confusion for the past two weeks. The patient looks jaundiced and admits to chronic alcohol use. You run a CBC and see the attached cells in the microscope. What other findings can you expect in this patient?

a)

Peripheral lipoatrophy

b)

Inclusion bodies

c)

Decreased plasma cholesterol levels

d)

Increased plasma cholesterol levels

8.

Fill in the blanks: Ran ___ is activated by a Ran ___ into Ran ___, then inactivated by Ran ___ to return to Ran ___.

a)

GTP; GAP; GDP; GEF; GTP

b)

GTP; GEF; GDP; GAP; GTP

c)

GDP; GEF; GTP; GAP; GDP

d)

GDP; GAP; GTP; GEF; GDP

9.

An investigation is performed for a patient with sudden heart failure, limited flexion of the neck, and muscle weakness which uncovers that the patient's cardiac and skeletal muscle fiber nuclei are fragile. A mutation in which gene would explain these findings?

a)

Spectrin

b)

LMNA

c)

SMN

d)

LMNB

10.

Which of the following target signals would direct a protein into a peroxisome?

a)

NLS

b)

KDEL

c)

M6P

d)

KKXX

e)

SKL

11.

What are the correct pairings of vesicle constituents involved in docking and fusion?

a)

Rab-GTP & tethering protein; v-SNARE & t-SNARE

b)

Rab-GTP & v-SNARE; t-SNARE & tethering protein

c)

Ran-GTP & tethering protein; v-SNARE & t-SNARE

d)

Rab-GTP & tethering protein; Ran-GTP and NSF

12.

A patient with Familial Hypercholesterolemia has a class II LDL receptor defect. Which process is interrupted in this person?

a)

Clustering into coated pit

b)

Synthesis of receptor in ER

c)

Transport to p.m.

d)

Binding at p.m.

e)

Recycling vesicle back to p.m.

13.

Hutchinson-Gilford Progeria is a laminopathy characterized by altered lamin A that results in an unstable NE. What are other results of the altered lamin A structure in these patients?

a)

Accumulation of adipose tissue in face and neck

b)

Increased serum cholesterol

c)

Inclusion body formation

d)

Loss of peripheral heterochromatin

14.

When looking at the following slide under a microscope, you notice the cells have prominent nucleoli and very eosinophilic cytoplasm. What can you infer about the function of the cells?

a)

Highly metabolic

b)

Highly secretory

c)

Lowly mitotic

d)

Lowly oxidizing

e)

Function can't be determined

15.

A patient comes in for a biopsy of a tumor on their adrenal cortex. Which cellular feature would you expect to be prominent under microscopic evaluation?

a)

Mitochondria

b)

RER

c)

Golgi

d)

Lysosomes

e)

SER