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WorksheetsWeek 7 MCB Tutoring
Total questions: 15
Worksheet time: 9mins
From a molecular biology perspective, what is the cause of Cystic Fibrosis?
Improper clathrin-pit formation
Defective cotranslational translocation
Incorrect protein folding
Excessive N-linked glycosylation
Which of the following describes the flow of proteins through the Golgi apparatus?
cis-Golgi to Golgi stack to trans-Golgi
cis-Golgi to trans-Golgi to Golgi stack
Golgi stack to cis-Golgi to trans-Golgi
Golgi stack to trans-Golgi to cis-Golgi
Trans-Golgi to Golgi stack to cis-Golgi
What is the likely fate of a free-floating protein without a molecular tag located in the Golgi apparatus?
Cytosolic protein
Golgi apparatus protein
Lysosomal protein
Membrane protein
Secretory protein
A male infant is born with bilateral dislocated hips, restricted shoulder and elbow joints, cloudy corneas, and course facial features. Which of the following is the location of the dysfunctional enzyme responsible for the most likely diagnosis in this patient?
Endosomes
Proteasome
Golgi apparatus
RER
SER
You walk into the ER and encounter a peculiar patient. The patient complains of neck stiffness, dysphagia, and lockjaw. The patient states they stepped on a rusty nail, but thought nothing of it. Chances are this patient was exposed to the ____ toxin, which degraded ____.
Tetanus / synaptobrevin
Tetanus / syntaxin
Botulin / synaptobrevin
Botulin / syntaxin
A molecule of glucose is needing entry into a cell. Which class of plasma membrane protein would grant access for this molecule?
Membrane channel
Transporter
Receptor
Gap junction
A patient presents to the clinic with feelings of fatigue, weakness, and confusion for the past two weeks. The patient looks jaundiced and admits to chronic alcohol use. You run a CBC and see the attached cells in the microscope. What other findings can you expect in this patient?
Peripheral lipoatrophy
Inclusion bodies
Decreased plasma cholesterol levels
Increased plasma cholesterol levels
Fill in the blanks: Ran ___ is activated by a Ran ___ into Ran ___, then inactivated by Ran ___ to return to Ran ___.
GTP; GAP; GDP; GEF; GTP
GTP; GEF; GDP; GAP; GTP
GDP; GEF; GTP; GAP; GDP
GDP; GAP; GTP; GEF; GDP
An investigation is performed for a patient with sudden heart failure, limited flexion of the neck, and muscle weakness which uncovers that the patient's cardiac and skeletal muscle fiber nuclei are fragile. A mutation in which gene would explain these findings?
Spectrin
LMNA
SMN
LMNB
Which of the following target signals would direct a protein into a peroxisome?
NLS
KDEL
M6P
KKXX
SKL
What are the correct pairings of vesicle constituents involved in docking and fusion?
Rab-GTP & tethering protein; v-SNARE & t-SNARE
Rab-GTP & v-SNARE; t-SNARE & tethering protein
Ran-GTP & tethering protein; v-SNARE & t-SNARE
Rab-GTP & tethering protein; Ran-GTP and NSF
A patient with Familial Hypercholesterolemia has a class II LDL receptor defect. Which process is interrupted in this person?
Clustering into coated pit
Synthesis of receptor in ER
Transport to p.m.
Binding at p.m.
Recycling vesicle back to p.m.
Hutchinson-Gilford Progeria is a laminopathy characterized by altered lamin A that results in an unstable NE. What are other results of the altered lamin A structure in these patients?
Accumulation of adipose tissue in face and neck
Increased serum cholesterol
Inclusion body formation
Loss of peripheral heterochromatin
When looking at the following slide under a microscope, you notice the cells have prominent nucleoli and very eosinophilic cytoplasm. What can you infer about the function of the cells?
Highly metabolic
Highly secretory
Lowly mitotic
Lowly oxidizing
Function can't be determined
A patient comes in for a biopsy of a tumor on their adrenal cortex. Which cellular feature would you expect to be prominent under microscopic evaluation?
Mitochondria
RER
Golgi
Lysosomes
SER
