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WorksheetsCirrhosis Pharm
Total questions: 36
Worksheet time: 20mins
Which of the following is a function of the liver?
conversion of ammonia to urea
production of anti coagulation factors
synthesis and storage
metabolism
detoxification
Which medication can lead to the development of cirrhosis?
amoxicillin
amiodarone
amitryptilline
ampicillin
Which is a way blood enters the liver?
hepatic vein
portal vein
inferior vena cava
cystic duct
Which of the following labs is least likely in a cirrhotic patient?
decreased alkaline phosphate
elevated INR
elevated total bilirubin
decreased platelets
What scoring model is used to describe severity and prognosis, as well as predict complications in cirrhotic patients?
Glasgow
Child-Pugh
MELD
GOLD
Portal hypertension is defined as a hepatic venous pressure gradient greater than what value?
7 mmHg
5 mmHg
3 mmHg
4mmHg
What is the most common lethal complication of cirrhosis?
Spontaneous bacterial peritonitis
Variceal hemorrhage
Portal Hypertention
Hepatic encephalopathy
What is the gold standard to diagnose varisces?
Colonoscopy
EGD
CT abdomen
abdominal XR
True or False:
Fibrosis can be reversible if Hepatic stellate cells are depleted before cirrhosis stage is reached.
True
False
At what size would you be concerned for possible variceal bleeding?
> 5 m
> 5 mm
> 5 cm
> 3 mm
A pt is found to have a 3 mm varice and fits into Child-Pugh Class B. What is the best appropriate management for this pt?
Amlodipine
Nadalol
atenolol
EVL
Which of the following would be a contraindication for non-selective beta blocker therapy?
asthma
acute heart failure
baseline bradycardia
heart block
tachycardia
Which of the following is NOT indicated for an acute variceal hemorrhage?
IV epinephrine
EVL
IV Ceftriaxone
IV Octreotide
Which drug is a potent splanchnic vasoconstrictor that helps reduce blood flow to all splanchnic organs, which leads to decrease in portal pressure ?
Spironolactone
Octreotide
Nadolol
Ceftriaxone
Which of the following adverse effects should you be aware of before starting Octreotide?
hypoglycemia
hyperglycemia
bradycardia
abdominal distention
What is the drug of choice for someone presenting with an acute variceal hemorrhage for prophylactic antibiotics?
Metronidazole
Ceftriaxone
Ciprofloxacin
Vancomycin
A pt is has been hemorrhaging due to a large variceal rupture. No pharmacologic intervention has slowed the bleeding. Which of the following could you consider next?
transjugular intrahepatic portosystemic shunt (TIPS)
balloon tamponade
chest slap
gut punch
Which of the following in combo is considered the most effective regimen for secondary prophylaxis of pts with a history of variceal bleed?
ENT
Propranolol
EVL
Atenolol
Which is the safest and most effective option for controlling acute hemorrhage?
balloon tamponade
TIPS
EVL
Sclerotherapy
What is the most common complication of cirrhosis?
hepatic encephalopathy
ascites
portal hypertension
variceal hemorrhage
What should be done for every patient with new-onset ascites or hospitalized for complications of cirrhosis?
CT abdomen
paracentesis
EGD
abdominal XR
What value of SAAG would indicate portal hypertension?
>3
> 1.1 -2.5
> 2.5
< 1.1
A pt presents with new onset of ascites and overall fatigue. Your ascitic fluid analysis reveals PMNs > 250 cells/mm^3. What should you be most concerned of/not miss on diagnosing?
hepatic encephalopathy
Spontaneous bacterial peritonitis
ascites
portal hypertension
What ratio is important to maintain when starting furosemide and spironolactone for ascites?
400:100
40:100
4:1
40:10
You are given a case with new onset of ascites. Which of the following adverse effects should you consider when starting the appropriate drugs?
hyperkalemia
gynecomastia
metabolic alkalosis
muscle cramps
A 56 year old patient presents with ascites and undergoes paracentesis. His SAAG is calculated to be 1.3. What cause of ascites does this indicate?
pancreatic ascites
portal hypertension
nephrotic syndrome
malignancy
Which is a diuretic used in the treatment of ascites?
Furosemide
Metolazone
Acetazolamide
Spironolactone
A pt presents to the ER with abdominal pain. On exam you note that the pt is febrile with increasing ascites. You are suspecting spontaneous bacterial peritonitis. What would most likely be found on the culture of the ascitic fluid?
mycosplasma
E. coli
Pseudomonas
M. cattarhalis
True or False:
Ascitic fluid, urine, and blood should be drawn for culturing after starting empiric antibiotic therapy.
False
True
Antibiotics are indicated if patient presents with ascites and 1 or more
of the following:
abdominal pain or tenderness
temp > 37.8 C or 100 F
PMNs >250 cells/mm^3
PMNs <250 cells/mm^3
A pt returns for follow up after starting treatment for SBP. Labs show a decrease in PMN <25% from baseline. What is the next best step in managing this patient?
EVL
repeat paracentesis
hydrocortisone
Bactrim
A pt presents with a Low ascitic protein (<1.5 g/dL) and BUN 35 mg/dL. What is the best agent option in managing this pt?
Metronidazole
Bactrim
Ceftriaxone
Nadolol
A pt presents to the ER with Altered mental status. Upon examining the patient, you notice that the patient is very irritable with loss of motor control. What lab would direct your diagnosis?
CK
ammonia
SCr
BUN
What is the first line treatment of hepatic encephalopathy?
rifaximin
lactulose
octreotide
ceftriaxone
Which of the following is an antibiotic that helps alter the gut microbiota to create a more favorable microbiome and less nitrogen production?
rifaximin
lactulose
ceftriaxone
octreotide
What antibiotic is appropriate first-line empiric therapy for active SBP?
clindamycin
cefotaxime
meropenem
piperacillin/tazobactam
