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WorksheetsLicense preparation 2
Total questions: 65
Worksheet time: 38mins
Enzyme associated with male hermaphroditism
(a)
A 45 year old firefighter was found collapsed in a building on fire. His oxygen saturation by pulse oximetry is 98%. What is expected to increase in his blood?
Sulfhemoglobin
Methemoglobin
Carboxyhemoglobin
S-nitrosohemoglobin
Carbaminohemoglobin
ABC company has plan to produce and market insulin gargling. What is the most important data to submit to FDA?
Animal studies
Biosimilar
Bioavailability
Bioequivalence
Phrase 4 clinical trial
A 50 year old malnourished alcoholic man presented with fatigue for 2 months. Hb 9, Hct 28, WBC 5,000 (N60,L30,M6,E3,B1), Plt 150,000, MCV 110. Maccroovulocyte hypersegmented PMN
Decreased haptoglobin synthesis
Decreased Hb synthesis
Decreased RBC maturation
Increased RBC destruction in spleen
Defect RBC membrane
Which medication is likely affect iron absorption?
Enalapril
Omeprazole
Simenthicone
Domperidone
Hydrochlorothiazide
เด็กชายอายุ 1 ปี เกิดมาปกติ ไม่มีอาการอะไร แต่พออายุ 6 เดือน เริ่มมีอาการของ Anemia ได้รับการวินิจฉัยว่าเป็น homozygous β-thalassemia ถามว่าทำไมเพิ่งจะเกิดอาการตอนนี้
decreased erythropoietin
decreased HbF synthesis
decreased heme synthesis
ชายอายุ 40 ปี นอนโรงพยาบาล เพื่อทำ autograft stem cell transplantation ถามว่า stem cell ของชายคนนี้ผลิตที่ใด
Liver
Spleen
Rib
Pelvis
Tibia
A 5 year old boy presents with bloody vomiting, bloody diarrhea, and petechiae. Examination: BT 38.0 ° C , normal coagulogram, Hb 10 g/dl, Plt 212,000/mm3. What is the most likely diagnosis?
Antiphospholipid syndrome
Hemolytic uremic syndrome
Idiopathic thrombocytopenia
Disseminated intravascular coagulation
Thrombotic thrombocytopenia purpura
A 30 year old woman presents with abdominal blunt pain and severe blood loss. Hct drops to 28% from 33% after postoperative bleeding still remain, which of the following should be found in peripheral blood smear 3 days after post-operation.
Schistocyte
Reticulosis
Hypochromic RBC
Leucoerythroblastic cell
Basophilic stippling
เจอ beta2-microglobulin in urine ถามว่า เกิดจาก exposure ของสารใด
(a)
Thrombosis at SMA, which organ is affected?
Stomach
Duodenum
Jejunum
Sigmoid
Descending colon
A 10 year old boy has hemophilia A. His mother’s brother suffers with the same condition. Who is the obligated carrier of this disease?
His mother
His older sister
Mother of his father
Mother of his mother
A 25 year old woman presents with 2 cm cut lesion on her hand. What substance help about platelet aggregation in hemostasis?
P-selectin
ADP receptors
Glycoprotein IIb/IIIa
Prostanoid receptors
Intracellular adhesion molecule
A 60 year old woman presents with lethargy, confusion and trunk pain เคยทำ modified radical ที่เต้านมข้างซ้าย (เป็นมะเร็ง) X-rays พบ lytic lesion ที่ femur ผลเลือดควรเป็นอย่างไร
Hyper K
Hyper Na
Hyper Ca
Hypo Mg
Hypoglycemia
เป็น acute MI ได้รับ streptokinase สารอะไรเพิ่ม
Thrombin
Antithrombin
Plasmin
Activated protein C
A 2 year old boy is brought to the hospital by his parents who are concerned about the multiple bruises on the boy’s body. Blood examination found PT 13 seconds and aPTT52 seconds. There is a history of similar conditions in male family members. Which of the following coagulation factors is most likely defect in this patient?
III
V
VII
VIII
XI
pH 7.33, PCO2 70, HCO3 36
Which one of the following is physiological compensation?
Hyperventilation
Excretion of NH4
Secretion of HCO3
Decreased titratable acid secretion
Decreased NaCl reabsorption
A 10 year old has headache, puffy eyelid and bilateral leg edema for 2 days. Two weeks ago, she had sore throat and fever relieved by consuming over the counter drug. PE: blood pressure 140/80. UA: protein 2+, RBC 5-10 /upfront, red cell cast 1-2/lpf. Which of the following condition is most compatible with the clinical presentation?
Lupus Nephritis
Acute kidney injury
Minimal change glomerulonephritis
Drug-induce IN
Acute poststreptococcal glomerulonephritis
A 6 year old boy presents with protein uric. 4+, hypercholesterolemia, and hypoalbuminemia. What is the most likely finding when renal biopsy is performed.
Subendothelial immune deposit
Diffuse foot process effacement
Subepithelial hump like deposit
Pathology of membranous nephropathy
(a)
What is the most common nephrotic syndrome in children?
(a)
What is the most common nephritic syndrome in children?
(a)
What is the pathology of IgA nephropathy?
(a)
พบ dysmorphic RBC, RBC 5-10/field, มี massive hematuria ถามว่าเกิดอะไรก่อนหน้านี้
Penicillin hypersensitivity
Bacterial skin infection 3-4 weeks ก่อน
Bacterial pharyngitis 1-2 วันก่อน
URI 1-2 week ก่อน
กินกล้วยเยอะ โพแทสเซียมสูง ถามว่า กลไกใดที่ทำให้ โพแทสเซียมในเลือดยังมีค่าปกติ
ขับ K+ ออกที่ thick ascending limb
เพิ่ม Na+ - K+ ATPase pump ที่ collecting duct
มีอาการหูหนวก & อาการทางไต ถามว่าเสีย collagen type ใด
1
2
3
4
ทุก type
After eating high protein diet for 4 hours. Which mechanism causes high urine output?
Increased plasma protein
Increased plasma tonicity
Increased plasma sodium
Decreased urine protein
Decreased sodium reabsorption
Which interleukin associated with stimulation of IgA production?
(a)
Which interleukin is associated with neutrophil chemotaxis?
(a)
Which interleukin is associated with bone marrow stimulation?
(a)
Which interleukin is associated with stimulation of acute phrase protein?
(a)
A 25 year old man present with cough and dyspnea. He was diagnosed with lobar pneumonia. Sputum was collected for gram stain. Which immune component is involved?
Cytokine
Eosinophil
Macrophage
Complement
Immunoglobulin
มี erythmatous vesicular papule หลังจากสัมผัส rove beetle ต่อย ถาม immune mechanism
Innate immunity
Anaphylactic reaction
Cell mediated immune response
Humoral immune response
โดนมดกัดแล้วบวมเกิดจากอะไร
(a)
กิน analgesic drug แล้ว 30 นาทีต่อมาเกิด generalized urticaria, face and lips edema. What is the mechanism?
Neutrophil infiltration
CD 8+ T cell cytotoxic
Mast cell degranulation
Complement activation
ADCC
การติดเชื้อวัณโรคที่ทำให้เกิดเป็น Caseous necrosis ที่เป็นเช่นนี้เพราะ cytokine ชนิดใด
IL-1
IL-2
TNF-α
IL-17
IFN- γ
การติดเชื้อไวรัส cytokine ชนิดใดป้องกันการติดเชื้อให้แก่เซลล์ข้างเคียง
TGF-β
TNF-α
IFN-α
IFN- γ
IL-10
การติดเชื้อไวรัส เซลล์ชนิดใดจะตอบสนองเป็นลำดับแรก?
Neutrophil
Eosinophil
Basophil
Lymphocyte
Natural killer cell
เด็กชายวัย 10 ขวบ ถูกมดแดงกัด สักพักมีอาการบวม,แดง,ร้อน เซลล์ใดเป็นต้นเหตุของอาการนี้
Natural killer cell
Basophil
Eosinophil
Mast cell
Neutrophil
ผู้หญิงสวมสร้อยข้อมือที่เพิ่งซื้อมาใหม่ หลังจากนั้น 1 สัปดาห์ก็มีผื่นขึ้นบริเวณที่ใส่ เพราะกลไกใด
CMIR
HMIR
ADCC
Opsonization
Complement
Prevalence of PKU = 1/40,000 ถาม frequency ของ PKU carrier
1/50
1/100
1/200
1/400
1/800
Hardy Weinberg law assumption include
(a)
A 20 year old male presents with throbbing headache, nausea, palpitation and flushed on head, neck and trunk after drank 2 glasses of alcohol. Which of the following substances is the cause of his symptoms?
Ethanol
Methanol
Acetate
Formate
Acetaldehyde
What is the energy source for brain after fasting for several weeks?
(a)
What is the energy source for body after fasting for more than 8 hours but less than 1 day?
(a)
What is the energy source for body after starving for less than 8 hours?
(a)
A 20 year old woman with poorly-controlled type 1 diabetes presents with nausea and vomiting, fruity scanted breath and Kussmaul breathing pattern. Her blood sugar is 500 mg/dL. Which of the following is associated with this condition?
Decreased ketogenesis
Decreased fatty acid beta-oxidation
Increased glycolysis
Increased glycogenesis
Increased gluconeogenesis
A 30 year old presents with a shortness of breath for 3 hours, PE: RR 23/min, using accessory muscles to his respiration, wheezing both lung fields. Which of the following substances mostly mediates with his condition?
IL-8
Lipoxin
Leukotriene
Prostacyclin
Thromboxane A2
ผู้หญิงอายุ 30 ปี มี dysmenorrhea แท้งเมื่อ 5 ปีก่อน พบ numerous hemorrhagic lesions 0.2-0.5 cm at perineal membrane over ovary ถาม DX
Leiomyoma
Brenner tumor
Endometriosis
Krukenberg tumor
Pelvic inflammatory disease
เด็ก term normal labor คลอดออกมา cyanosis หายเขียวหลังร้องไห้PE ปกติ กลไกอะไรทำให้หายเขียว
Increased PaCO2
Increased pulmonary artery pH
Decreased pulmonary vascular resistance
Preterm newborn postpartum have a dyspnea and cyanosis
CXR: seen multiple bowel in chest cavity and seen mediastinum shift the opposite. What mechanism is defected?
Viteline duct
Lateral body wall
Costodiaphramatic recess
Pleuroperitoneal membrane
Dorsal mesentery of esophagus
คนไข้เป็นอะไร?
(a)
รักษาด้วยอะไร
(a)
PBS ของ thalassemia
(a)
PBS ของ iron deficiency anemia
(a)
A 20 year old female presented with easy fatigue and dyspnea for 3 months. She had a history of 20 year poor controlled diabetes millitus. Recently, she was diagnosed with diabetic retinopathy and neuropathy. Physical examination showed pale conjunctiva. Complete blood count showed Hb 9g/dL, Hct 28%, MCV 90 fL, MCH 30 pg (normal range 27-33), RDW 13.5% (normal range 11.5-14.5), WBC 8,500/mm3, platelet 200,000/mm3, HbA1C 12%. Which of the following was the most likely cause of anemia?
Hemolysis
Nephropathy
Iron deficiency anemia
Folate deficiency
Bone marrow suppression
A 52 year old man presented to his physician for a routine check up. He reported increasing fatigue and has a smooth, sore tongue. He was a strict vegan and had undergone bariatric surgery 3 years ago. Physical examination was notable for decreased vibration sensation and proprioception. Laboratory studies demonstrated a macrocytic anemia with reticulocytopenia. Peripheral blood smear was shown. Which was the most likely cause?
Aplastic anemia
Sideroblastic anemia
Megaloblastic anemia
Iron deficiency anemia
Anemia of chronic disease
A 20 year old male presented with easy fatigue and dyspnea for 2 months. He was then diagnosed with iron deficiency anemia. Ferrous sulfate was administered. Which of the following diet should be taken with the agent to facilitate absorption?
Milk
Rice
Orange juice
Green tea
Calcium carbonate
A 68 year old man presented to his primary care physician with complaints of weakness and fatigue over the past half year. Physical examination revealed moderately pale, no jaundice, no hepatosplenomegaly. Blood test showed Hb 7g/dL, MCV 70 fL, WBC 5,600/mm3, Reticulocyte count 1%. A fecal occult blood test was shown to be positive for blood in the stool. Which of the following agents should be administered?
Folic acid
Pyridoxine
Erythropoietin
Ferrous sulfate
Cyanocobalamin
A 26 year old male was initially admitted to a hospital with a 10 day history of intermittent fever, headaches, rigors, and chills, and a 1 day history of nausea, vomiting, and diffuse abdominal pain. His symptoms began 5 months after returning from a 10 day camp in the forest in Thailand which he has received multiple mosquito bites. On admission, the patient was alert and oriented with a temperature of 38 °C , heart rate of 124 bpm, and blood pressure of 93/44 mm/Hg. Physical examination findings were significant for diffuse abdominal tenderness and petechial rash on the lower extremities bilaterally. After chloroquine and primaquine was taken, his urine turned dark brown. Supravital stain of his blood showed Heinz body. Which of the following substances decreased in RBC?
ATP
2,3-DPG
Pyruvate kinase
Reduced glutathione
Glucose-6-phosphatase
A 50 year old male presented with dyspnea for 2 months. Physical examination revealed markedly pale conjunctiva. Other examinations were unremarkable. Complete blood count revealed CBC: Hb 7 g/dL, Hct 20%, MCV 70 fL, reticulocyte 1%, WBC 5,000/mm3 (neutrophil 70%, lymphocyte 30%). Hb typing: HbA2A, HbA2 2%. Which of the following was the most likely cause?
Renal failure
Liver Cirrhosis
Gastric carcinoma
Chronic lung disease
Beta-thalassemia/HbE disease
A 30 year old male presented with abdominal pain and melena for 3 months. Physical examination was unremarkable except for markedly pale conjunctiva. Complete blood count showed Hct 23%, WBC 3,200/mm3 (N30%, L70%), platelet 50,000/mm3, MCV 89 fL. Which was the most likely pathogenesis?
Decreased RBC production
RBC destruction from spleen
RBC destruction from antibody
Nutritional deficiency for RBC production
Decreased hematopoietic stem cells
A 20 year old female was diagnosed with hemolytic jaundice since she was born. Physical examination revealed splenomegaly. Blood smear showed small-sized RBC without central pallor. Her mother had similar finding. Which of the following was the most likely pathogenesis?
Abnormal hemoglobin
Abnormal cytoskeleton
Decreased cell membrane synthesis
Increased cytoplasmic content
Cell membrane destruction by macrophage
A 40 year old female presented with pale and easy fatigue. Physical examination showed none of hepatosplenomegaly or lymphadenopathy. Complete blood count showed Hb 8 g/dL, Hct 25%, MCV 70 fL, reticulocyte 1%. She was treated appropriately. After the treatment, which of the following parameters would change first?
MCV
Serum ferritin
Hemoglobin
Serum ferritin
Reticulocyte count
A 50 year old female presented with easy fatigue for 3 months. Physical examination revealed pale conjunctiva without icteric sclerae. Liver and spleen were not enlarged. Complete blood count showed Hb 6 g/dL, MCV 120 fL, WBC 3,800/mm3 (N70%, L30%), platelet 180,000/mm3. Which of the following laboratory was most appropriate for the case?
Serum ferritin
Serum cobalamin
Thyroid function test
Direct anti globulin test
Hemoglobin electrophoresis
