WorksheetsPC- Antiemetic Drugs
Total questions: 19
Worksheet time: 12mins
Which of the following receptors is involved in N/V patho?
H1 receptors
M1 receptors
D2 receptors
5HT3 receptors
5HT1 receptors
Which two receptors are expressed in the chemoreceptor trigger zone?
chemoreceptors
D2 receptors
nicotinic receptors
serotonin receptors
muscarinic receptors
Which of the following is responsible for inducing motion sickness?
vestibular
chemoreceptor
vomiting center
central nervous system
GIT is rich in what type of receptors that induce vomiting upon stimulation?
mechanoreceptors
serotonin (5HT3)
chemoreceptors
H1 receptors
5HT3 antagonists are clinically used for which of the following?
the prevention of acute chemotherapy-induced nausea and emesis
the prevention of motion sickness
the prevention and treatment of post-radiation N/V
Which of the following pharmaceutical preparations are antipsychotic agents that mediate antiemetic effect by blocking dopamine and muscarinic receptors?
prochlorperazine
promethazine
clozapine
droperidol
How does droperidol induce its antiemetic effect?
blocking dopamine receptors
blocking muscarinic receptors
blocking H1 receptors
all of these
Which of the following is NOT a dopamine receptor antagonist?
domperidone
risperidone
diphenhydramine
paliperidone
Which of the following is used in treatment for motion sickness?
diphenhydramine
dimenhydrinate
domeperidone
prochlorperazine
What is the MOA for dimenhydrinate?
stimulate appetite and prevents vomiting through unknown mechanism
D2 receptor antagonist and used mainly as pro kinetic agent
blocking of H1 receptors and muscarinic receptors in the vestibular system
block GABA receptors
What is the MOA of Fosaprepitant?
largely unknown
central blocking of NK1 receptors
stimulate appetite and prevent vomiting
blocking of H1 or muscarinic receptors
Benzodiazepines can be used for all of the following conditions EXCEPT
to reduce anticipatory vomiting
to reduce anxiety-induced vomiting
to induce sedation
to prevent chemotherapy induced vomiting
What other indications are risperidone and paliperidone used for?
manic depressive disorder
schizophrenia
diabetes insipidus
none of these
Which of the following is a side effect of dolasetron?
weight loss
insomnia
QT prolongation
sedation
What is the MOA for cannabinoids?
used before chemo to reduce anticipatory vomiting or anxiety-induced vomiting by blocking GABA receptors
blocking of H1 receptors or muscarinic receptors in the vestibular system
psychoactive agents used to stimulate appetite and prevents emesis through unknown mechanism
psychoactive agents that mediate their antiemetic effect by blocking dopamine and muscarinic receptors
Which of the following is a dopamine agonist that can be used as an emetic?
droperidol
apomorphine
domeperidone
doxylamine
What non-pharm treatments can pregnant women use for N/V?
herbal supplements, such as ginger
acupressure
chiropractic care
none of these
Which of the following is/are considered first line antiemetic(s) for pregnancy?
pyridoxine
pyridoxine+doxylamine
folic acid
ondansetron
Which is false about dronabinol?
it is a cannabinoid receptors CB1 and CB2 agonist
it is a cannabinoid receptors CB1 and CB2 antagonist
it is closely related to Nabilone
it has orexigenic effect
