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Toxic Responses to Kidney II

Total questions: 10

Worksheet time: 5mins

Name
Class
Date
1.

The target of acetaminophen-induced renal injury is

a)

Distal tubule

b)

Proximal tubule

c)

Glomerulus

d)

Loop of Henle

2.

The following nephrotoxicants were discussed in the lecture EXCEPT?

a)

NSAIDs

b)

Contrasting agents

c)

Cancer therapeutics

d)

Drugs of abuse

3.

The folllowing substances cause hemodynamic alteration EXCEPT:

a)

NSAIDs

b)

Amphotecerin B

c)

Contrasting agemts

d)

Lithium

4.

The following is FALSE regarding the mechanism of drug-induced nephrotoxicity:

a)

Altering intraglomerular hemodynamics

b)

Increasing GFR

c)

Tubular cell toxicity

d)

Inflammation

5.

Overdose of acetaminophen causes accumulation of toxic metabolite

a)

mercapturic aicd.

b)

glutathione.

c)

cysteine.

d)

N-acetyl-p-benzoquinone-imine.

6.

Cyclosporine-induced nephrotoxicity may dsplay the following EXCEPT:

a)

acute reversible renal dysfunction

b)

acute vasculopathy

c)

nephrolithiasis

d)

chronic nephropathy with interstitial fibrosis

7.

The followings are symptoms of acute kidney injury:

I. swelling in legs

II. fatigue

II. confusion

IV. seizures

a)

I and II

b)

II and III

c)

I, II and III

d)

All of the above

8.

The standard battery of noninvasive tests includes:

I. measurement of urine volume

II. measurement of osmolality

III. measurement of pH

IV. measurement of urinary composition

a)

I and III

b)

I and IV

c)

I, III and IV

d)

All of the above

9.

The followings suggest adverse reaction of drug-induced nephrotoxicity:

      I. Low systolic blood pressure

     II. Low urea-to-creatinine ratio

III. DecreaseI renal flow blood flow

IV. Decrease estimated glomerular filtrate rate

a)

I and IV

b)

I and III

c)

II and III

d)

None of the above

10.

The followings are nephrotoxic::

I. fluoxetine

II. penicillin

III. ibuprofen

IV. niacin

a)

I and II

b)

I and III

c)

I, II and III

d)

All of the above