WorksheetsPCC2 - Exam 3 - Suppositories
Total questions: 59
Worksheet time: 30mins
Name
Class
Date
1.
What type of dosage form is a suppository
a)
solid
b)
liquid
c)
oral
d)
rectal
e)
parenteral
2.
Inserts are dosage forms that are inserted into a naturally occuring body cavity including the mouth or rectum
a)
true
b)
false (other than the mouth or rectum)
3.
Sticks is a solid dosage form designed for ___ drug administration
a)
oral
b)
sublingual
c)
parenteral
d)
topical<br />
e)
rectal
4.
Vaginal inserts are also known as
a)
pessaries
b)
vaginal suppositories
c)
bougies
d)
tablets
e)
ointment
5.
Suppositories are solid dosage forms inserted into the rectal area to provide
a)
local effect
b)
systemic effect
6.
What type of action do suppositories that promote defecation have
a)
local effect
b)
systemic effect
7.
What type of action do suppositories that treat anorectal diseases have
a)
local effect
b)
systemic effect
8.
What type of action do suppositories that introduce drugs into the body have
a)
local effect
b)
systemic effect
9.
An adult suppository weighs about
a)
1 gm
b)
2 gm
c)
3 gm
d)
4 gm
10.
What rectal vein drains into the liver
a)
superior haemorrhoidal vein
b)
middle haemorrhoidal vein
c)
inferior haemorrhoidal vein
11.
What rectal vein(s) drains into the heart
a)
superior haemorrhoidal vein
b)
middle haemorrhoidal vein
c)
inferior haemorrhoidal vein
12.
What are some characteristics of rectal drug absorption
a)
passive diffusion
b)
unpredictable bioavailability
c)
typically lower rate and extent of drug absorption as compared to oral route<br />
d)
active diffusion
e)
predictable bioavailability
13.
An advantage of rectal administration over oral administration is that hepatic first-pass elimination of high clearance drugs is fully avoided
a)
true
b)
false (partially avoided)
c)
false (not avoided)
14.
What are some advantages that rectal administration of drugs have over oral administration
a)
ideal for drugs liable to degredation in the GI
b)
suitable for drugs that irritate the stomach
c)
relatively large doses can be administered
d)
taste/smell masking
e)
hepatic first-pass elimination of high clearance drugs is fully avoided
15.
What are some physiological factors that can affect rectal drug absorption
a)
quantity of fluid available
b)
property of rectal mucus
c)
contents of rectum
d)
motility of the rectal wall
e)
lymphatic circulation
16.
What are some physicochemical properties of APIs that affect rectal drug absorption
a)
solubility in water & vehicle
b)
surface properties
c)
particle size
d)
amount
e)
pKa
17.
What are some limitations to rectal administration
a)
poor patient compliance
b)
upward movment of the dosage form can increase first-pass metabolism
c)
suppositories can leak
d)
insertion can be problematic
e)
erratic absorption
18.
Shape is an important characteristics of a vaginal insert and should be carefully designed
a)
true
b)
false (not important)
19.
What shape do vaginal inserts have
a)
globular
b)
oviform
c)
cone shaped
d)
cylinder
20.
What are some benefits to drugs taken vaginally
a)
local drug delivery, preferential delivery to the uterus
b)
oral intake is restricted, favorable alternative to parenteral administration
c)
when drug is not suitable for oral administration due to stability issues
d)
avoids hepatic first-pass effect
e)
enables self administration and removal
21.
What is the order of vaginal drug absorption
a)
drug release from delivery system, drug dissolution in vaginal lumen, penetration through the vaginal walls
b)
drug dissolution in vaginal lumen, drug release from delivery system, penetration through the vaginal walls
c)
penetration through the vaginal walls, drug release from delivery system, drug dissolution in vaginal lumen
d)
drug release from the delivery system, penetration through the vaginal walls, drug dissolution in vaginal lumen
22.
The blood supply surrounding the vagina drains into the vaginal vein and goes into the peripheral circulation. This will go through first-pass metabolism<br />
a)
true
b)
false (no first pass metabolism)
23.
What are some physiological factors that can affect vaginal drug absorption
a)
epithelium thickness
b)
pH
c)
amount, composition, and viscosity of vaginal fluids
d)
Fecal matter
24.
What are some physicochemical properties of APIs that affect vaginal drug absorption
a)
molecular weight
b)
lipophilicity
c)
ionization
d)
surface charge
e)
particle size
25.
What is the most desireable treatment for vaginal disorders
a)
vaginal inserts
b)
suppositories
c)
topical gels
d)
oral antibiotics
e)
douching
26.
What are some limitations of vaginal administration of drugs
a)
gender specific
b)
cyclic physiological variations
c)
premature discharge/leakage
d)
systemic absorption of drug intended for local effect
e)
misperceptions
27.
What are some physicochemical properties of bases used for suppositories or vaginal inserts
a)
composition
b)
melting behavior
c)
rheological properties
d)
freezing behavior
28.
What is the standard USP base and why
a)
cocoa butter
b)
exhibits polymorphism
c)
semi synthetic fatty bases
d)
exhibits no polymorphism
29.
Which base has a higher amount of saturated fatty acids and why would this form be selected as a base
a)
cocoa butter
b)
exhibits polymorphism
c)
semi synthetic fatty bases
d)
exhibits no polymorphism
30.
What are some characteristics of aqueous bases
a)
less frequently used
b)
melting point is above body temperature
c)
does not melt at body temperature, is slowly dissolved in body fluids
d)
more stable
e)
less stable
31.
How much water do PEG suppositories need to contain to prevent irritation
a)
5%
b)
10%
c)
15%
d)
20%
e)
25%
32.
PEG 200-400 is
a)
liquid at room temp
b)
clear, colorless
c)
semisolid
d)
wax-like, white
e)
solid
33.
PEG 1000-1500 is
a)
liquid at room temp
b)
clear, colorless
c)
semisolid
d)
wax-like, white
e)
solid
34.
PEG 1540-20k is
a)
liquid at room temp
b)
clear, colorless
c)
semisolid
d)
wax-like, white
e)
solid
35.
What are some potential issues for aqueous bases
a)
hygroscopicity
b)
tend to slow down drug release
c)
susceptible to oxidation
d)
number of incompatibilities
36.
What are some characteristics of glycerinated gelatin base
a)
translucent, gelatinous mixture
b)
not for rectal use
c)
hygroscopic
d)
suitable for vaginal use
e)
suitable for rectal use
37.
What are some disadvantages of glycerinated gelatin base
a)
associated physiolgoical effect
b)
manufacturing issue
c)
hygroscopicity
d)
potential interactions with APIs
e)
only for rectal use
38.
Which are semi-synthetic fatty bases
a)
witepsols
b)
fattibase
c)
cocoa butter
d)
PEG
e)
polybase
39.
Which is a commercial water-soluble base
a)
witepsols
b)
fattibase
c)
cocoa butter
d)
PEG
e)
polybase
40.
What are some melting point increasing agents that may be used in aqueous bases
a)
beeswax
b)
magnesium stearate
c)
colloidal silicon dioxide
d)
PEG
e)
polysorbabe 80
41.
What are some melting point decreasing agents that may be used in aqueous bases
a)
beeswax
b)
magnesium stearate
c)
colloidal silicon dioxide
d)
PEG
e)
polysorbabe 80
42.
What is an example of a viscosity-increasing agent that may be used in aqeuous bases
a)
silica gel
b)
magnesium stearate
c)
colloidal silicon dioxide
d)
PEG
e)
polysorbabe 80
43.
What are some additional excipients that may be used in aqueous bases
a)
preservatives
b)
antioxidants
c)
surfactants
44.
If a drug's Log P value is over 1, is it hydrophilic or lipophilic
a)
hydrophilic
b)
lipophilic
45.
If a drug's Log P value is under 1, is it hydrophilic or lipophilic
a)
hydrophilic
b)
lipophilic
46.
If a drug solubility was oil-soluble and a fatty base was used, what would the drug release rate be
a)
slow release
b)
moderate
c)
rapid
47.
If a drug solubility was oil-soluble and a water-miscible base was used, what would the drug release rate be
a)
slow release
b)
moderate
c)
rapid
48.
If a drug solubility was water-miscible and a water-miscible base was used, what would the drug release rate be
a)
slow release
b)
moderate
c)
rapid
49.
If a drug solubility was water-soluble and a fatty base was used, what would the drug release rate be
a)
slow release
b)
moderate
c)
rapid
50.
What is the most common method for making suppositories
a)
fusion molding
b)
compression
c)
injection molding
51.
It is best to keep all suppositories refrigerated
a)
true
b)
false (does not need refrigeration)
52.
During quality assurance of suppositories, what is checked
a)
texture uniformity
b)
disintegration
c)
dissolution rate
d)
content uniformity
e)
floccules
53.
As a pharmacist, you are requested to develop a vaginal insert formulation of a weakly basic, highly lipophilic drug (Log P = 3.2). Propose the most suitable base for this formulation if a slower drug release rate is desired.
a)
Polyethylene Glycol Base
b)
Cocoa Butter
c)
Glycerinated Gelatin Base
54.
Rectal fluids have a high buffer capacity.
a)
true
b)
false (low buffer)
55.
Which of the following veins is responsible for subjecting drugs administered via the rectal route to the first-pass effect?
a)
superior haemorrhoidal vein
b)
middle haemorrhoidal vein
c)
inferior haemorrhoidal vein
56.
Which of the following counseling points are relevant upon dispensing fat-based suppositories or inserts?
a)
moisten suppository with water before insertion
b)
remove any wrapping material before insertion
c)
warm suppositories/inserts to room temperature before insertion
57.
An aqueous solution was prepared by dissolving 5 g of dextrose to make 350 mL of solution. What is the percentage (w/v) of the dextrose in this solution?
a)
14%
b)
0.7%
c)
1.4%
d)
5%
58.
What is the percentage of a drug in a solution if each milliliter of this solution contains 120 mg of the drug?
a)
1.2%
b)
0.012%
c)
0.12%
d)
12%
59.
How much dextrose is needed to prepare 2 L of a 12% solution?
a)
2.4 g
b)
24 g
c)
240 g
d)
240 mg
100 %
