wayground logo

Free Printable Worksheets

Font size

S
M
L
XL
Worksheets

Med Chem Antibacterial

Total questions: 56

Worksheet time: 32mins

Name
Class
Date
1.

The image is the pharmacophore for a class of antibiotics named after it. What is it called?

a)

β-lactam ring

b)

glycopeptide

c)

cyclic lipopeptide

2.

Which type of beta lactam is this?

a)

penem

b)

penam

c)

carbapenem

d)

cefem

e)

monobactam

3.

Which type of beta lactam is this?

a)

Penam

b)

Penem

c)

Carbapenam

d)

Cefem

e)

Monobactam

4.

Which type of beta lactam is this?

a)

Penam

b)

Penem

c)

Carbapenem

d)

Cefem

e)

Monobactam

5.

Which type of beta lactam is this?

a)

Cefem

b)

Penem

c)

Penam

d)

Carbapenem

e)

Monobactam

6.

Which type of beta lactam is this?

a)

Penam

b)

Penem

c)

Carbapenem

d)

Cefem

e)

Monobactam

7.

Another way to say Penams is what?

a)

penicillins

b)

cephalosporins

8.

Another way to say Cefems is what?

a)

Penicillins

b)

Cephalosporins

9.

What is the MOA of beta lactams?

a)

all function to inhibit cell wall transamidase

b)

inhibits transglycolases and transpeptidase activity

10.

Penams (penicillins) have what type of ring fused with the beta lactam?

a)

thiazolidine

b)

aminothiazolyl

11.

Which drugs are in the 1st generation of cephalosporins (cefems)?

a)

cefazolin

b)

cephalexin

c)

cefuroxime

d)

ceftriaxone

e)

cefepime

12.

Which drugs are in the 2nd generation of cephalosporins (cefems)?

a)

cefuroxime

b)

cefotetan

c)

cefoxitin

d)

cefprozil

e)

ceftazidime

13.

Which drugs are in the 3rd generation of cephalosporins?

a)

cefotaxime

b)

ceftazidime

c)

cefpodoxime proxetil

d)

ceftriaxone

e)

cefepime

14.

Which drugs are in the 4th generation of cephalosporins?

a)

cefepime

b)

ceftaroline

15.

Which drug is the Anti-MRSA cephalosporin?

a)

ceftaroline

b)

cephalexin

c)

cefepime

d)

cefuroxime

16.

Which of the following are carbapenems?

a)

imipenem

b)

meropenem

c)

ertapenem

d)

doripenem

e)

cilastatin

17.

Which of the following is a Monobactam?

a)

aztreonam

b)

cefepime

c)

imipenem

d)

daptomycin

18.

Which generation of cephalosporins in active against gram positive cocci, group A beta-hemolytic streptococci, group B streptococci, and streptococcus pneumoniae?

a)

1st

b)

2nd

c)

3rd

d)

4th

19.

Which generation of cephalosporins has a broader spectrum against gram-negative bacteria than the 1st gen?

a)

2nd

b)

3rd

c)

4th

20.

Which generation of cephalosporins has excellent anti-gram-negative activity, but less effective against staphylococci?

a)

1st

b)

2nd

c)

3rd

d)

4th

21.

Which generation of cephalosporins increases its beta-lactamase activity?

a)

1st

b)

2nd

c)

3rd

d)

4th

22.

Which subclass of beta lactam antibiotics is active against most aerobic and anaerobic gram positive and gram negative bacteria including S aureus, P aeruginosa and B fragilis?

a)

carbapenems

b)

cepahlosporins

c)

penicillins

23.

Which subclass of beta lactams is active against gram negative aerobic microorganisms that are resistant to antibiotics hydrolyzed by beta lactamases?

a)

monobactams

b)

carbapenems

c)

cephalosporins

d)

penicillins

24.

What is the MOA of glycopeptides?

a)

inhibits transglycolases and transpeptidase activity

b)

binds to cell membranes and causes depolarization which interferes with protein, DNA, and RNA synthesis

25.

Choose the Glycopeptides:

a)

vancomycin

b)

oritavancin

c)

dalbavancin

d)

telavancin

e)

daptomycin

26.

What is the MOA of the cyclic lipopeptides?

a)

inhibits transglycolases and transpeptidase activity

b)

binds to cell membranes and causes depolarization which interferes with protein, DNA, and RNA synthesis

27.

Which of the following is a cyclic lipopeptide?

a)

daptomycin

b)

vancomycin

28.

Fosfomycin tromethamine is a broad spectrum antibiotic that inhibits UDP-N-acetylglucosamine-3-enolpyruvyltransferase (MurA)

a)

true

b)

false

29.

Which drug class has the following MOA: molecules bind single-stranded DNA, not the DNA gyrase but still cause the inhibition of DNA unwinding.

a)

fluoroquinolones

b)

beta lactams

c)

cyclic glycopeptide

30.

Which P450 does ciprofloxacin inhibit?

a)

CYP1A2

b)

CYP3A4

c)

CYP2D6

31.

Which generation of fluoroquinolone is not valuable for systemic infections?

a)

1

b)

2

c)

3

d)

4

32.

Which generation of fluoroquinolone is good for systemic infections, including those from gram negative organisms such as P aeruginosa; weak activity against S pneumoniae, no activity against anaerobes?

a)

1

b)

2

c)

3

d)

4

33.

Which generation of fluoroquinolone is active against S pneumoniae and atypical bacteria, less active against P aeruginosa?

a)

1

b)

2

c)

3

d)

4

34.

Which generation of fluoroquinolone is active against anaerobes and aerobic gram positive and gram negative organisms?

a)

1

b)

2

c)

3

d)

4

35.

Nalidixic acid and cinoxacin are in which generation of fluoroquinolone?

a)

1

b)

2

c)

3

d)

4

36.

Norfloxacin, Lomefloxacin, Enoxacin, Ofloxacin, and Ciprofloxacin are in which generation of fluoroquinolone?

a)

1

b)

2

c)

3

d)

4

37.

Levofloxacin, Sparfloxacin, Gatifloxacin, and Gemifloxacin are in which generation of fluoroquinolone?

a)

1

b)

2

c)

3

d)

4

38.

Trovafloxacin and Moxifloxacin are in which generation of fluoroquinolone?

a)

1

b)

2

c)

3

d)

4

39.

Rifampin is a potent inducer of which P450?

a)

CYP1A2

b)

CYP2D6

c)

CYPP3A4

40.

Rifampin is primarily for what?

a)

tuberculosis

b)

strep throat

c)

thrush

d)

gram negative bacteria

41.

Which drug has the following MOA: inhibits bacterial RNA synthesis, binds beta subunit of DNA-dependent RNA polymerase, preventing attachment of the enzyme to DNA, and thus blocking initiation of RNA transcription?

a)

rifampin

b)

ciprofloxacin

c)

metronidazole

d)

metformin

42.

Which is the main drug in the Folic Acid Inhibitor class of medications?

a)

Bactrim (sulfamethoxazole/trimethoprim)

b)

metronidazole

c)

fluconazole

d)

amoxicillin

43.

Which of the following are Protein Synthesis Inhibitors? (bacteriostatic)

a)

tetracyclines

b)

glycylcyclines

c)

macrolides

d)

lincosamides

e)

oxazolidinones

44.

Which is the only non-bacterioststaic subclass of the protein synthesis inhibitors?

a)

tetracyclines

b)

macrolides

c)

aminoglycosides

d)

lincosamides

45.

Which subclass of protein synthesis inhibitors does the following MOA belong to? bind to the 30S subunit which interferes with protein biosynthesis and causes bacteriostasis

a)

tetracyclines

b)

macrolides

c)

aminoglycosides

d)

lincosamides

46.

Which subclass of protein synthesis inhibitors does the following MOA belong to? binds to the 30S ribosomal subunit and blocks peptide synthesis

a)

glycylcycline

b)

tetracycline

c)

macrolide

d)

lincosamide

47.

Which subclass of protein synthesis inhibitors does the following MOA belong to? bind to the 16S rRNA portion of the 30S ribosome subunit; prevents the proofreading function of the ribosome

a)

aminoglycoside

b)

tetracycline

c)

glycylcycline

d)

oxazolidinone

48.

Which subclass of protein synthesis inhibitors does the following MOA belong to? bind specifically to the 50S subunit of the ribosome and interferes with protein biosynthesis (bacterial, not human)

a)

macrolide (and a ketolide)

b)

aminoglycoside

c)

tetracycline

49.

Which of the following medications are tetracyclines?

a)

tetracycline

b)

doxycycline

c)

monocycline

d)

demeclocycline

e)

tigecycline

50.

Which of the following medications are glycylcyclines?

a)

tigecycline

b)

tetracycline

c)

doxycycline

d)

erythromycin

51.

Which of the following medications are aminoglycosides?

a)

streptomycin

b)

neomycin

c)

kanamycin

d)

amikacin

e)

doxycycline

52.

Which of the following medications are aminoglycosides? (pt 2)

a)

gentamicin

b)

tobramycin

c)

cephalexin

d)

clindamycin

53.

Which of the following medications are macrolides and a ketolide?

a)

erythromycin

b)

clarithromycin

c)

azithromycin

d)

telithromycin (ketolide)

e)

clindamycin

54.

Fidaxomicin is a macrocyclic antibiotic that is effective against C Diff by inhibiting RNA polymerase.

a)

true

b)

false

55.

Which of the following medications are lincosamides?

a)

clindamycin

b)

erythromycin

c)

daptomycin

d)

vancomycin

e)

lincomycin

56.

Which of the following medications are oxazolidinones?

a)

linezolid

b)

tedizold phosphate

c)

amoxicillin

d)

amphotericin B