WorksheetsMed Chem Antibacterial
Total questions: 56
Worksheet time: 32mins
The image is the pharmacophore for a class of antibiotics named after it. What is it called?
β-lactam ring
glycopeptide
cyclic lipopeptide
Which type of beta lactam is this?
penem
penam
carbapenem
cefem
monobactam
Which type of beta lactam is this?
Penam
Penem
Carbapenam
Cefem
Monobactam
Which type of beta lactam is this?
Penam
Penem
Carbapenem
Cefem
Monobactam
Which type of beta lactam is this?
Cefem
Penem
Penam
Carbapenem
Monobactam
Which type of beta lactam is this?
Penam
Penem
Carbapenem
Cefem
Monobactam
Another way to say Penams is what?
penicillins
cephalosporins
Another way to say Cefems is what?
Penicillins
Cephalosporins
What is the MOA of beta lactams?
all function to inhibit cell wall transamidase
inhibits transglycolases and transpeptidase activity
Penams (penicillins) have what type of ring fused with the beta lactam?
thiazolidine
aminothiazolyl
Which drugs are in the 1st generation of cephalosporins (cefems)?
cefazolin
cephalexin
cefuroxime
ceftriaxone
cefepime
Which drugs are in the 2nd generation of cephalosporins (cefems)?
cefuroxime
cefotetan
cefoxitin
cefprozil
ceftazidime
Which drugs are in the 3rd generation of cephalosporins?
cefotaxime
ceftazidime
cefpodoxime proxetil
ceftriaxone
cefepime
Which drugs are in the 4th generation of cephalosporins?
cefepime
ceftaroline
Which drug is the Anti-MRSA cephalosporin?
ceftaroline
cephalexin
cefepime
cefuroxime
Which of the following are carbapenems?
imipenem
meropenem
ertapenem
doripenem
cilastatin
Which of the following is a Monobactam?
aztreonam
cefepime
imipenem
daptomycin
Which generation of cephalosporins in active against gram positive cocci, group A beta-hemolytic streptococci, group B streptococci, and streptococcus pneumoniae?
1st
2nd
3rd
4th
Which generation of cephalosporins has a broader spectrum against gram-negative bacteria than the 1st gen?
2nd
3rd
4th
Which generation of cephalosporins has excellent anti-gram-negative activity, but less effective against staphylococci?
1st
2nd
3rd
4th
Which generation of cephalosporins increases its beta-lactamase activity?
1st
2nd
3rd
4th
Which subclass of beta lactam antibiotics is active against most aerobic and anaerobic gram positive and gram negative bacteria including S aureus, P aeruginosa and B fragilis?
carbapenems
cepahlosporins
penicillins
Which subclass of beta lactams is active against gram negative aerobic microorganisms that are resistant to antibiotics hydrolyzed by beta lactamases?
monobactams
carbapenems
cephalosporins
penicillins
What is the MOA of glycopeptides?
inhibits transglycolases and transpeptidase activity
binds to cell membranes and causes depolarization which interferes with protein, DNA, and RNA synthesis
Choose the Glycopeptides:
vancomycin
oritavancin
dalbavancin
telavancin
daptomycin
What is the MOA of the cyclic lipopeptides?
inhibits transglycolases and transpeptidase activity
binds to cell membranes and causes depolarization which interferes with protein, DNA, and RNA synthesis
Which of the following is a cyclic lipopeptide?
daptomycin
vancomycin
Fosfomycin tromethamine is a broad spectrum antibiotic that inhibits UDP-N-acetylglucosamine-3-enolpyruvyltransferase (MurA)
true
false
Which drug class has the following MOA: molecules bind single-stranded DNA, not the DNA gyrase but still cause the inhibition of DNA unwinding.
fluoroquinolones
beta lactams
cyclic glycopeptide
Which P450 does ciprofloxacin inhibit?
CYP1A2
CYP3A4
CYP2D6
Which generation of fluoroquinolone is not valuable for systemic infections?
1
2
3
4
Which generation of fluoroquinolone is good for systemic infections, including those from gram negative organisms such as P aeruginosa; weak activity against S pneumoniae, no activity against anaerobes?
1
2
3
4
Which generation of fluoroquinolone is active against S pneumoniae and atypical bacteria, less active against P aeruginosa?
1
2
3
4
Which generation of fluoroquinolone is active against anaerobes and aerobic gram positive and gram negative organisms?
1
2
3
4
Nalidixic acid and cinoxacin are in which generation of fluoroquinolone?
1
2
3
4
Norfloxacin, Lomefloxacin, Enoxacin, Ofloxacin, and Ciprofloxacin are in which generation of fluoroquinolone?
1
2
3
4
Levofloxacin, Sparfloxacin, Gatifloxacin, and Gemifloxacin are in which generation of fluoroquinolone?
1
2
3
4
Trovafloxacin and Moxifloxacin are in which generation of fluoroquinolone?
1
2
3
4
Rifampin is a potent inducer of which P450?
CYP1A2
CYP2D6
CYPP3A4
Rifampin is primarily for what?
tuberculosis
strep throat
thrush
gram negative bacteria
Which drug has the following MOA: inhibits bacterial RNA synthesis, binds beta subunit of DNA-dependent RNA polymerase, preventing attachment of the enzyme to DNA, and thus blocking initiation of RNA transcription?
rifampin
ciprofloxacin
metronidazole
metformin
Which is the main drug in the Folic Acid Inhibitor class of medications?
Bactrim (sulfamethoxazole/trimethoprim)
metronidazole
fluconazole
amoxicillin
Which of the following are Protein Synthesis Inhibitors? (bacteriostatic)
tetracyclines
glycylcyclines
macrolides
lincosamides
oxazolidinones
Which is the only non-bacterioststaic subclass of the protein synthesis inhibitors?
tetracyclines
macrolides
aminoglycosides
lincosamides
Which subclass of protein synthesis inhibitors does the following MOA belong to? bind to the 30S subunit which interferes with protein biosynthesis and causes bacteriostasis
tetracyclines
macrolides
aminoglycosides
lincosamides
Which subclass of protein synthesis inhibitors does the following MOA belong to? binds to the 30S ribosomal subunit and blocks peptide synthesis
glycylcycline
tetracycline
macrolide
lincosamide
Which subclass of protein synthesis inhibitors does the following MOA belong to? bind to the 16S rRNA portion of the 30S ribosome subunit; prevents the proofreading function of the ribosome
aminoglycoside
tetracycline
glycylcycline
oxazolidinone
Which subclass of protein synthesis inhibitors does the following MOA belong to? bind specifically to the 50S subunit of the ribosome and interferes with protein biosynthesis (bacterial, not human)
macrolide (and a ketolide)
aminoglycoside
tetracycline
Which of the following medications are tetracyclines?
tetracycline
doxycycline
monocycline
demeclocycline
tigecycline
Which of the following medications are glycylcyclines?
tigecycline
tetracycline
doxycycline
erythromycin
Which of the following medications are aminoglycosides?
streptomycin
neomycin
kanamycin
amikacin
doxycycline
Which of the following medications are aminoglycosides? (pt 2)
gentamicin
tobramycin
cephalexin
clindamycin
Which of the following medications are macrolides and a ketolide?
erythromycin
clarithromycin
azithromycin
telithromycin (ketolide)
clindamycin
Fidaxomicin is a macrocyclic antibiotic that is effective against C Diff by inhibiting RNA polymerase.
true
false
Which of the following medications are lincosamides?
clindamycin
erythromycin
daptomycin
vancomycin
lincomycin
Which of the following medications are oxazolidinones?
linezolid
tedizold phosphate
amoxicillin
amphotericin B
