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WorksheetsPharmaceutics Exam 1: Dr. Yang Part 2
Total questions: 20
Worksheet time: 5hrs 0mins
Pulmonary Drug delivery is usually a locally delivered drug meaning it is inhaled and works on the target location on the body and does not get delivered systemically
True
False
Which of these is NOT a part of the three regions in the respiratory tract?
Esophagus
Alveolar
Nasopharyngeal & Oropharyngeal
Tracheobronchial
The further away from the mouth, the smaller the surface area
True
False
The diameter of the airways _____ with the _____ generation of the airways
decreases;
increasing
decreases;
decreasing
increases;
increasing
increases;
increasing
Which of these are advantages of pulmonary drug delivery?
Can produce a local and systemic effect
Avoids first pass effect
Lower dose increases adverse reactions
Cost of device
Non-invasive
What are the disadvantages of pulmonary drug delivery?
Avoids degradation in GIT
Slower onset of action
cost of device
Possibility of local side effects due to oropharyngeal deposition
Complex engineering to develop device
Probability of deposition ______ with each bifurcation
Does not change
Increases
Decreases
Increases and Decreases
Formulation for nasal delivery can be delivered by mouth
True
False
If a drug is inhaled by the nose, most of the particles are deposited where?
Pharynx
Nose
Mouth
Deeper into the lung
Slow inhalation flow rate allows the aerosol to penetrate more readily to target receptor sites
True
False
_____ in tidal volume results in ____ penetration of aerosol particles deeper into the distal tracheobronchial and alveolar regions
Decrease; less
Decrease; greater
Increase; less
Increase; greater
What is the recommended amount of time to hold your breath for efficient deposition?
5-10 seconds
3-12 seconds
10-15 seconds
2-8 seconds
Narrowing of airways by mucus, inflammation or bronchial constriction can _____ linear velocities
Increase
Decrease
Does not change
Where will an aerosol droplet likely deposit in the lung
Tracheobronchial region
Alveolar region
Nasopharyngeal region
Oropharyngeal region
Aerosol particle size is very important to determine the dose deposited and the distribution of the drug in the lungs. Drug particles for pulmonary delivery are usually characterized by geometric diameter rather then aerodynamic diameter.
True
False
Which of these best defines inertial impaction
>5 μ m
Between
0.5-3 μ m
<0.5 μ m
Between
1-5 μ m
Which of these best define gravitational sedimentation
Increases with particle velocity, diameter, and density
Diffusion increases with the decrease in particle size and breath holding following inhalation
Mainly occurs in bronchioles and alveoli
Time dependent and mainly occurs in small airways
Which of these best defines Brownian diffusion
Mainly occurs where air stream velocity is low (last 5 to 6 generations)
Mainly occurs in zones of highest airflow velocity (first 10 generations)
Not usually observed for aerosol delivery
Important in the bronchioles, alveoli, and bronchial bifurcations
Which of the following is true about particle deposition?
Particles between
5-10 μ m are deposited on tracheobronchial surface
Pulmonary drugs are never delivered as particles and mainly delivered as droplets
50% of
5 μ m particles are deposited into the alveoli by diffusion
Particles
1-5 μ m show efficient penetration into the lungs
Particles
>10 μ m are usually removed by coughing, swallowing, and mucocilary processes
Hygroscopicity and solvent evaporation can also affect particle size
True
False
