What is the most potent pharmacologic inhibitor of sebum secretion?

Antimicrobial peptides, including cathelicidin, psoriasin, β-defensin 1, and β-defensin 2, are expressed within the sebaceous gland. Among these peptides, which has direct antimicrobial activity against P. acnes?

If the average transit time of a keratinocyte from the basal layer to desquamation is 28 days, what is the average transit time of sebaceous gland cells from formation to discharge?

What fatty acid is thought to be unique to human sebum?

Which type of hair has an anagen duration of 1-2 weeks?

Increased activity of which of the following genes is associated with thicker hair in Asians?

Nail stem cells have been found to have a role in digit regeneration. This is mediated by which molecular pathway?

Tumors may augment blood supply by intussusceptive angiogenesis, vasculogenic mimicry, vessel co-option, or vasculogenesis. Among these mechanisms, which one appears to play a specifict role in metastatic melanoma?

You were called to the ER to check on a 45/F with erythroderma. You did a skin punch biopsy which showed confluent parakeratosis, regular epidermal hyperplasia, and elongated dermal papillae with tortuous capillaries at the tips and extravasation of neutrophils and lymphocytes.

What do you call the phenomenon by which the capillary loops within the tips of the papillae dilate, elongate, and at the turnaround point touch the epidermis?

A 22/M came in for few well-defined gray patches on the left gluteal area. The patient reported that these lesions have been constantly reappearing for the past 6 months, becoming inflamed then healing with hyperpigmentation. Upon further history taking, you note that he is an athlete and has been taking ibuprofen intermittently for muscle soreness after training. The patient’s problem is explained by the presence of which cells?

Which leukocyte is characterized by surface expression of the high-affinity Fc receptor for immunoglobulin E, secretion of large quantities of IL-4, and inability to proliferate?

Your 18month/F patient with scaly rose colored papules and plaques on the diaper region does not respond to topical corticosteroid. You decided to do a skin punch biopsy which showed dense proliferations of oval-shaped cells with an eosinophilic cytoplasm and reniform nuclei in the dermis. What stain are you going to request?

What fat-soluble vitamin is required for efficient intracellular killing of pathogens by macrophages?

The S100 calcium-binding protein A7 (S100A7), also known as Psoriasin, is an AMP with a baseline production by keratinocytes. Its antimicrobial effect is mainly directed against which pathogen?