Hypersensitivity that occurs within 48-72 hours, has local induration, infiltrate of Lymphocytes, macrophages, and monocytes. The antigen is intradermal.

Hypersensitivity that occurs within 21-28days, has hardening effect, infiltrate of Epitheloid cells, macrophages, giant cells and fibrosis. The antigen is persistent or antibody complexes or non-immunoglobulin stimuli.

Are the main APC responsible for initiating contact sensitivity:

Are essential for stimulating Hapten-specific T cells.

LCs express MHC class _____, CD1 and, ______ (CD207), which is responsible for the development of Birbeck granules, an organelle characteristic of LCs.

_______ cells are derived from activated macrophages under the chronic stimulation of cytokines; thus, they potentiate continuing inflammation

in _______ leprosy, the skin have a few well-defined hypopigmented patches with an intense lymphocytic and epithelioid cell infiltrate and no microorganisms

In ________leprosy shows multiple confluent skin lesions with numerous bacilli, ‘foamy’ macrophages, and a paucity of lymphocytes

In ________, the granuloma provides the microenvironment in which lymphocytes stimulate macrophages to kill the intracellular microorganism.

In ________ the cytokines IL-5 and IL-13 are responsible for the recruitment of eosinophils and the formation of the granulomas around the ova leading to the Hepatic scarring and Portal hypertension.

Chronic disease in which activated macrophages, non-caseating granuloma and fibrosis accumulate in many tissues.

In Sarcoidosis ACE and Calcium are:

In ________ there is an excessive T cell-driven immune response to microbial antigens in genetically predisposed individuals