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Dr. J MODIFIED RELEASE DOSAGE FORM

Total questions: 89

Worksheet time: 6hrs 46mins

Name
Class
Date
1.

Which of the following are ADVANTAGES of Controlled or Modified Release Dosage Form? Select all that apply

a)

Reduced frequency of drug administration

b)

Improved patient compliance

c)

Maintain the therapeutic level of a drug for a longer duration

d)

Obtain continuous effect of the drug as a consequence of constant blood level

e)

Reduced local irritation of drug substance in the G.I. (gastrointestinal) tract due to high local concentration

2.

Which of the following are ADVANTAGES of Controlled or Modified Release Dosage Form? Select all that apply

a)

Reduced frequency of drug administration

b)

It is possible to orally administer a drug that is not stable in the acidic environment of the stomach

c)

Improved patient compliance

d)

Obtain continuous effect of the drug as a consequence of constant blood level

e)

Less patient compliance

3.

 

Which of the following are LIMITATIONS of Controlled or Modified Release Dosage Form? Select all that apply

a)

Improved patient compliance

b)

Drugs with narrow therapeutic range

c)

Drugs with a large (> than 500 to 600  mg) conventional dose

d)

Reduced frequency of drug administration

4.

Incorporation of immediate and controlled release doses will generate a small volume product (easy to swallow)

a)

True

b)

False

5.

Incorporation of immediate and controlled release doses will generate a large volume product (difficult to swallow)

a)

True

b)

False

6.

In practice, oral controlled release dosage forms are better suited for drugs with which of the following elimination half-life?

a)

shorter (7-9 hr.)

b)

shorter (2-6 hr.)

c)

longer (10-16 hr.)

d)

longer (12-16 hr.)

7.

Drugs with long half-life (> 10 hrs.) are inherently sustained action and, therefore, are administered less frequently.

a)

True

b)

False

8.

Drugs with short half-life (2-6 hrs.) are inherently sustained action and, therefore, are administered less frequently.

a)

True

b)

False

9.

Which of the following drugs are examples with long elimination half- life

(t1/2)? Select all that apply

a)

Diazepam

b)

Warfarin

c)

Chlordiazepoxide

d)

Digitoxin

e)

Wellbutrin XL

10.

 

Which of the following drugs has the longest elimination half life (t1/2)?

a)

Diazepam

b)

Warfarin

c)

Chlordiazepoxide

d)

Digitoxin

e)

Phenobarbital

11.

Extremely insoluble drugs are not well suited for this type of dosage form since they tend to be absorbed slowly.

a)

True

b)

False

12.

Which of the following statements is TRUE regarding Controlled or Modified Release Dosage Forms?

a)

Less expensive

b)

If administered too frequently, undesirable high blood level of a drug may result due to repetition of the loading dose and accumulation factor.

c)

Extremely soluble drugs are not well suited for this type of dosage form since they tend to be absorbed slowly

d)

Increase frequency of drug administration

13.

If administered too frequently, undesirable high blood level of a drug may result due to repetition of the loading dose and accumulation factor.

a)

True

b)

False

14.

All of the following are goals of Modified Release Dosage Forms, EXCEPT ?

a)

Reduce the frequency of dose administration

b)

To control the drug release from the dosage form

c)

Slower the rate of drug absorption AND Prolong the duration of action

d)

Accelerate the rate of drug absorption AND Prolong the duration of action

15.

Which of the following are examples of drugs and polymer coated beads in a capsule? Select all that apply

a)

Micro K

b)

Prilosec

c)

Prevacid

d)

Nexium

e)

Adderall

16.

Which of the following is a product in which a portion of the dose is available immediately to produce the effect quickly and another portion is incorporated as a slow-release portion?

a)

Repeat action

b)

Sustained release

c)

Slow release

17.

Which of the following system utilizes repetitive dosing of a drug from one or more immediate release units incorporated into a single dosage form?

a)

Repeat Action

b)

Slow release

c)

Sustained release

18.

Which of the following Modified release drug delivery systems does not produce or maintain uniform drug blood levels within the therapeutic range?

a)

Sustained release

b)

Repeat action

c)

Slow release

19.

Which of the following the desired drug concentration is attained slowly and therefore longer duration)?

a)

Slow release

b)

Repeat action

c)

Sustained release

20.

Which of the following are examples of Enteric coated tablets? Select all that apply

a)

Aspirin

b)

Delayed action

 ProtonixR tablet

c)

Concerta

d)

Wellbutrin XL

e)

EC-Naprosyn

21.

In Coated Slow Release Beads, the dose of the drug is divided in how many groups of beads?

a)

15

b)

10

c)

20

d)

30

22.

Which of the following is TRUE about Core spherical beads?

a)

This layer contains the active   ingredient (drug)

b)

is applied by   dissolving in a suitable solvent.

c)

made up of sugar   or other inert material

d)

made up of stomach acids   or other inert material

23.

Which of the following is TRUE about the Coated Drug Layer?

a)

made up of sugar   or other inert material

b)

This layer contains the active   ingredient (drug), which is applied by   dissolving in a suitable solvent.

c)

made up of stomach acids or other inert material

d)

This layer contains the excipients (inactive) ingredients of a drug

24.

Which of the following will contain a fixing agent such methyl cellulose or other suitable polymer (fixing agent)?

a)

Coated drug layer

b)

Core spherical beads

c)

Coating material

25.

In the coating material, The solution or aqueous dispersion of polymeric material is applied to the beads prepared by using step I and II and the Wurster process.

a)

True

b)

False

26.

The thickness of the coat applied will control the release of a drug from beads.

a)

True

b)

False

27.

Which of the following statements are TRUE in controlling the drug release from beads? Select all that apply

a)

Polymer and its physical/chemical properties

b)

thin coating will release the drug faster

c)

thicker coating will release the drug slower

d)

thin coating will release the drug slower

e)

thickness of the coat

28.

Which of the following physical/chemical properties will play an important role in controlling the drug release from the beads? Select all that apply

a)

permeability

b)

molecular weight

c)

pore size

d)

solubility

e)

stability

29.

Which of the following are examples of Osmotically Controlled Drug Release? Select all that apply

a)

Glucotrol XL

b)

Procardia XL

c)

Wellbutrin XL

d)

Ditropan XL

e)

Concerta

30.

Porosity (Ɛ) is inversely related and inversely proportional to the compressional forces.

a)

True

b)

False

31.

Porosity (Ɛ) is inversely related (but not inversely proportional) to the compressional forces.

a)

True

b)

False

32.

Which of the following are true about POROSITY and TORTUOSITY regarding units?

a)

hr.-1

b)

dimensionless units (no units)

c)

mg/hr

d)

mg/sec

e)

hr.-1/2

33.

The higher the compressional forces, the lower will be the matrix porosity.

a)

True

b)

False

34.

The higher the compressional forces, the higher will be the matrix porosity

a)

True

b)

False

35.

The higher the compressional forces, the higher is the matrix tortuosity.

a)

True

b)

False

36.

The lower the compressional forces, the higher is the matrix tortuosity (τ).

a)

True

b)

False

37.

The increase of TORTUOSITY IS NOT directly proportional with an increase in the compressional forces.

a)

True

b)

False

38.

Which of the following is determined from the knowledge of bulk and true densities of the powder? 

a)

Porosity

b)

Tortuosity

39.

The higher the tortuosity, slower is the drug release in a non disintegrating matrix.

a)

True

b)

False

40.

The lower the tortuosity, slower is the drug release in a non disintegrating matrix.

a)

True

b)

False

41.

Which of the following values will represent an absence of tortuous path and therefore lower tortuosity?

a)

2

b)

0

c)

3

d)

4

e)

1

42.

Which of the following a presence of tortuous path and therefore HIGHER tortuosity?

a)

1.5

b)

2

c)

2.5

d)

1

e)

0

43.

Which of the following drugs are examples of drugs removed from the body intact into feces and non disintegrating matrix? Select all that apply

a)

Theo-Dur

 

b)

Fero-GradumetR

c)

K-Dur

d)

Slow KR

e)

Micro K

44.

Which of the following is used to alter the tortuosity (t) of the matrix?

a)

Ammonia vapor

b)

Acetone vapor

c)

Chloride vapor

d)

Ketone vapor

45.

Tableted Mixed Release Granules contain granules prepared by conventional methods (carrying initial dose) and granules which are coated with slowly digestible or poorly soluble material.

a)

True

b)

False

46.

Which of the following is a modified release tablets with an immediate

release and slow-release portion?

a)

Aspirin

b)

Lamictal XR

c)

Diovan

d)

Concerta

47.

Which of the following is TRUE about Acrylic resin Eudragit LR?

a)

For enteric coating; insoluble at pH 2 to

  6; soluble at pH 7 to 8

b)

For enteric coating; insoluble at pH 2 to 5; soluble at pH 6 to 8

c)

Soluble at pH 2 to 5; swells at pH 5 to 8

 

48.

Which of the following is TRUE about Acrylic resin Eudragit SR?

a)

For enteric coating; insoluble at pH 2 to

  6; soluble at pH 7 to 8

b)

For enteric coating; insoluble at pH 2 to 5; soluble at pH 6 to 8

c)

Soluble at pH 2 to 5; swells at pH 5 to 8

  Eudragit RL and Eudragit RS

49.

Which of the following is TRUE about Acrylic resin Eudragit ER?

a)

For enteric coating; insoluble at pH 2 to 5; soluble at pH 6 to 8

b)

Soluble at pH 2 to 5; swells at pH 5 to 8

  Eudragit RL and Eudragit RS

c)

For enteric coating; insoluble at pH 2 to

  6; soluble at pH 7 to 8

50.

Which of the following polymers or cellulose derivatives is impermeable to aqueous fluids?

a)

Carboxymethyl cellulose

b)

Methylcellulose

c)

Ethyl cellulose

d)

Cellulose acetate

e)

Polyethylene glycols

51.

Which of the following units represent when one surface of the tablet is exposed to the dissolution fluid?

a)

hr.1 or mg.hr

b)

hr-½ or mg.hr-1/2

c)

mg/hr

d)

hr-1

52.

Higuchi square root equations is used for A Planar System with Homogeneous Matrix represented by units hr-½ or mg.hr-1/2.

a)

True

b)

False

53.

Which of the following units represent the equilibrium solubility of a drug in the matrix system?

a)

g/lit

b)

cm^2/seconds

c)

mg/hr

d)

hr.-1

54.

 

Which of the following units represent the diffusion coefficient of a drug?

a)

cm^2/seconds

b)

g/lit

c)

mg/hr

d)

hr.-1

55.

Which of the following influence diffusion coefficient? Select all that apply

a)

permeability

b)

absolute temperature

c)

viscosity

d)

stability

56.

In Planar surface granular matrix tablet only one surface of the tablet is available for drug release.

a)

True

b)

False

57.

The higher the viscosity the lower will be the diffusion coefficient.

a)

True

b)

False

58.

 

The higher the viscosity of the liquid the lower will be the diffusion coefficient.

a)

True

b)

False

59.

A small r value, the diffusion coefficient will be higher.

a)

True

b)

False

60.

Higuchi equation is only for Non disintegrating matrix.

a)

True

b)

False

61.

Higuchi equation is only for Polymer/coated beads.

a)

True

b)

False

62.

Higuchi plot is seen when the drug is released in diffusion controlled dosage form obtaining a straight line which means rate constant.

a)

True

b)

False

63.

Which of the following units is related in a cylindrical tablet to the radius dependent all surface rate constant?

a)

mg.hr or hr-1

b)

mg.hr-1/2 or hr-1/2

64.

Which of the following units represent the rate in zero order process in RL (recti linear log paper) so slope=0?

a)

mg/hr

b)

hr.-1

65.

All first order processes are exponential equation. Here in first order is constant percentage. In zero order is constant amount. Know the units.

a)

Yes

b)

No

66.

The rate of release in First order process is?

a)

mg/hr

b)

hr.-1

67.

90% Drug is released at Constant rate in zero order and then the other 10% follow the first order process which is the declining.

a)

Yes

b)

No

68.

In the RL paper the rate of release DOES NOT change with time

a)

Yes

b)

No

69.

In the SL Paper the line will be exactly the same (straight line with a negative slope)

a)

Yes

b)

No

70.

In Higuchi equation (square root equation) you get a straights line only if you plot the graph of the drug release against the square root of time.

a)

True

b)

False

71.

In Higuchi equation (square root equation) you get a straights line only if you plot the graph of the drug release against the time.

a)

True

b)

False

72.

Which of the following are examples of oral modified release drugs using the technique of polymer coated beads (capsules)? Select all that apply

a)

Micro K

b)

Prilosec

c)

Prevacid

d)

Nexium

e)

Adderall XR

73.

Which of the following are examples of oral modified release drugs using the technique of osmotically controlled drug release? Select all that apply

a)

Glucotrol XL

b)

Ditropan XL

c)

Wellbutrin XL

d)

Procardia XL

e)

Concerta

74.

Which of the following are examples of oral modified release drugs using the technique of SLOW drug release? Select all that apply

a)

Aciphex

b)

Cardizem SR

c)

Wellbutrin SR

d)

Glucotrol XL

e)

Micro K

75.

Which of the following are examples of oral modified release drugs using the technique of delayed drug release? Select all that apply

a)

Aciphex

b)

Cardizem SR

c)

Wellbutrin SR

d)

Slow K

e)

K Dur

76.

Which of the following are examples of oral modified release drugs using the technique of Non disintegrating matrix tablet ? Select all that apply

a)

Slow K

b)

K-dur

c)

Theo-dur

d)

Aciphex

e)

Micro K

77.

Which of the following are examples of oral modified release drugs using the technique of coating material (coated tablets)? Select all that apply

a)

Drixoral

b)

Klor-Con

c)

Ambien CR

d)

Slow K

e)

Theo-dur

78.

The duration of action is longer in Sustained release product than in Immediate release product.

a)

True

b)

False

79.

The duration of action is longer in Sustained release product than in Immediate release product.

a)

True

b)

False

80.

Drug solution is applied with the aid of a fixing agent/inactive ingredient/inert material/excipient.

a)

True

b)

False

81.

Drug solution is applied with the aid of Methylcellulose or other suitable polymer.

a)

Yes

b)

No

82.

The solution is sprayed on the core spherical beads by using the Wurster process.

a)

True

b)

False

83.

Which of the following drugs in the market use the principles of beads as a modified release dosage form? Select all that apply

a)

Ritalin LA

b)

Ornade Spansule and Dexedrin Spansule

c)

Micro K

d)

Deconnamine SR

e)

Indocin SR

84.

Which of the following drugs in the market use the principles of beads as a modified release dosage form? Select all that apply

a)

Nexium

b)

Inderal LA

c)

Trilipix

d)

Micro K

e)

K-dur

85.

All of the following drugs use the principles of beads as a modified release dosage form, EXCEPT?

a)

Micro K

b)

Adderall XR

c)

Nexium

d)

Prevacid

e)

K-dur

86.

The inert ‘ghost’ matrix (tablet with no drug inside) is removed from the body intact into kidneys or liver.

a)

True

b)

False

87.

The inert ‘ghost’ matrix (tablet with no drug inside) is removed from the body intact into feces.

a)

True

b)

False

88.

In Lamictal XR tablet the center of the tablet is the slow release portion.

a)

True

b)

False

89.

 

In Lamictal XR tablet the outer part of the tablet is the immediate release portion.

a)

True

b)

False

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