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WorksheetsDr J 1-3 PowerPoints (+ review from previous semesters)
Total questions: 25
Worksheet time: 13mins
What physiochemical properties of the polymer play an important role in drug release?
pharmacological activity
impermeability
molecular weight
pore size
Why is levothyroxine not available as a modified release dosage form?
narrow therapeutic index
high dose
long half-life
insolubility
Which are examples of drug and polymer coated beads in a capsule?
Tussionex
Micro-K
K-Dur
Klor-Con
Why is there interest in Modified Release Dosage Forms?
low costs of new drug development
pharmaceutical alternatives are interchangeable
patent extension
better targeting for certain disease states
Which are delayed release tablets?
Ambien CR
Prevacid
Adderall XR
Aciphex
What are limitations of modified release dosage forms?
increased GI irritation
patient compliance
slower rate of onset and absorption
length of elimination half-life
Which are enteric coated tablets?
Wellbutrin
Nexium
EC Naprosyn
Protonix
Why is phenobarbital not available as a modified release dosage form?
narrow therapeutic index
insolubility
high dose
long half-life
Which are factors that influence the drug release from oral controlled release products?
viscosity of solvent
diffusion coefficient
crystal nature
flowability
Within the layers of a coated bead, where is the active ingredient contained?
in the core of the bead
on the outside of the gelatin capsule
in the coating of polymeric material
on the Nu Peril seed
What is an example of a fixing agent?
PEG
magnesium sterate
methyl cellulose
ascorbic acid
Which of the following are considered osmotically controlled?
Aciphex
Drixoral
Adderall XR
Procardia XL
What will control the release of a drug from beads?
the hydrophilicity of the drug
the color coating of the bead
the number of beads
the thickness of the coating
Why is Digoxin not available as a modified dosage form?
narrow therapeutic index
high dose
insolubility
long half-life
Which are non-disintegrating type matrix tablets?
Slow K
Klor-Con
Glucotrol XR
Theo-Dur
What are advantages of modified release dosage forms?
cost
accumulation factor
faster onset of action
reduced frequency of administration
From the graph: What does B represent?
Immediate release product
Slow release product
Repeat action product
Sustained release product
Adderall SR and Adderall XL are interchangeable
True
False
Repeat action drug delivery systems produce or maintain uniform drug blood levels within the therapeutic range
True
False
What are the dimensions for Flux?
mg.cm-2.min-1
cm2.min-1
mg.cm-3. cm-1
no units
Flux increases with time
True
False
Fick's law of diffusion states that the rate of absorption (dC/dt) is inversely proportional to
The surface area (A) of a membrane
The partition coefficient (Km/f) of a drug
The diffusion coefficient (D) of the drug
The membrane thickness (h)
The diffusion coefficient of a solute is affected or influenced by
temperature
pressure
solvent properties
chemical nature
Which powder properties are intrinsic?
melting point
true density
porosity
specific surface
What are the units for Equilibrium Solubility?
mg/sec
mm2/gram
g/ml
no units
