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WorksheetsPODA ID ex 2 Cell Membrane Inhibitors
Total questions: 22
Worksheet time: 6hrs 30mins
In children, meningitis is caused by which organisms?
H. Flu
Strep Pneumoniae
Neisseria aeruginosa
Pseudomonas A.
Empirical treatment in children with meningitis include:
Rocephin + Vanco + Ampicillin
Clafora + Ampicillin + Vanco
Cefotaxime + Vanco + ampicillin
Ceftriaxone + vanco + ampicillin
Treatment for meningitis caused by pseudomonas aeruginosa?
Cefotaxime (Claforan)
Ceftazidime (Fortaz)
Ceftriaxone (Rocephin)
Ampicillin
WOTF is true about Fever/Sepsis of Unknown origin?
Caused by G(-) anaerobic bacilli
Caused by G(-) aerobic bacilli
Treat with Claforan or Rocephin + Aminoglycoside
Caused by CAPES; thus, treat with Maxipime
WOTF are matched correctly?
Maxitrol top (P/N/Dexa)
Neosporin susp (P/N/Grami)
Polysporin susp/sol (P/Grami)
Polytrim (P/Trimethoprim)
Match the following correctly:
Polymyxin B - Bacillus Polymyxa
Polymyxin E - Bacillus Colistinus
Gramicidin - Bacillus Breve
Polymyxin B - Paenibacillus
WOTF organisms are part of CAPES?
Citrobacter Freundii
& Acinetobacter
Clostridium Tetani
& Acinetobacter
E. Coli & Shingella
Pseudomonas Aeruginosa
Enterobacter & Serratia
WOTF does NOT have Bacitracin?
Maxitrol & Cortisporin
Polysporin susp/sol
Neosporin suspension
Neosporin oint
Polysporin oint
WOTF is used for Nosocomial infection caused by CAPES organism?
Ancef
Ceftriaxone
Maxipime
Cefepime
Claforan
WOTF is true about polymyxins:
Poly B given IM, IV, PO, Top, IT
Poly E given PO only
Poly E given PO and Top
Poly B (Aerosporin) & Poly E (Colistin)
Colistin can be given IV, but is not common
Polymyxin B (Aerosporin) adverse effects include?
Albuminuria & Azotemia
Muscle weakness & perioral paresthesia
Neuromuscular blockade
Resp. muscle paralysis -> apnea
WOTF MOA can be classified as a cationic detergent?
Aerosporin
Polymyxin B
Neomycin
Tetracyclines
Aerosporin is indicated for?
Penicillin resistant causing severe infx by Pseudomonas
Carbapenem Resistant Enterococcus (CRE)
ear/eye infx caused by Staph or pseudomonas
Infx caused by Proteus, Providencia, Serratia
Colistin is indicated for?
Ear/eye infections
CRE
Penicillin resistant
Proteus or Providencia infections
WOTF suggests for the management of CRE UTI?
Colistin
Temocillin
Phosphonomycin
Gentamycin
Which of the following is BEST classified as a KETOLIDE?
Dirithromycin
Dynabac
Telithromycin
Ketek
WOTF is true in regards to protein synthesis inhibitor (cytoplasm)?
AMNG work on 30s subunit and only cover G-
Tetracyclines work on 50s subunit and cover G+/-
Chloramphenicol life-saver in typhoid fever and cover G+/-
Macrolides, Ketek, Synercid, & Zyvox cover G+ and work on 50s
Telithromycin & Linezolid cover G+
SATA. Aminoglycosides:
Polar amino sugars that do not cross membrane readily
Oral AMNG are mainly for Portal Systemic Encephalopathy (hepatic coma)
Neomycin, Paromomycin, Kanamycin AMNG are given orally
AMNG do not cover G(-) aerobes
Nephrotoxic, neurotoxic, and ototoxic
WOTF AMNG are used for Portal Systemic Encephalopathy (PSE) aka hepatic coma?
Neomycin
Paromomycin
Kanamycin
Mycifradin
Gentamycin
WOTF AMNG can cause Cochlear/Hearing impairment?
Kanamycin
Amikacin
Netilmicin
Gentamicin
Streptomycin
SATA. Aminoglycosides:
It comes in Maitec liposomal inj of gentamycin for Mycobacteriym complex infection
Septopal impregnated beads into gentamicin for osteomyelitis
Highly polar thus cannot cross CSF but does cross placenta barrier
PPB 80% and half-life of 2-3 hrs
Select the correct order from worst to least nephrotoxic AMNG:
Kana=Gen> tobra >Strep
Kana=tobra > Gen >Strep
Kana=Strep > Gen >tobra
Strep=tobra > Gen >Kana
