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Mutations

Total questions: 16

Worksheet time: 8mins

Name
Class
Date
1.

Original DNA sequence: TTACGCAAG

DNA sequence following mutation: TTCGCAAG.

What type of mutation is this?

a)
Substitution
b)
Deletion
c)
Insertion
d)
Inversion
2.

The bottom DNA sequence in the image has been altered by this type of mutation

a)

substitution

b)

insertion

c)

deletion

d)

translocation

3.

A segment of DNA has base sequence GAC GAC CGC AAA ACA AGC. Due to deletion, the first base G is deleted. The likely effect of this on the coding of DNA segment is that

a)

the first amino acid will be different and all other will be like the original polypeptide.

b)

there will be no change in the polypeptide chain.

c)

the whole sequence of amino acids will be changed.

d)

the polypeptide chain will be two amino acids shorter

4.

Original DNA sequence: GAG CTC GAC AGA

DNA sequence following mutation: GAG CTC CAC AGA

What type of mutation is this?

a)

frameshift

b)
substitution
c)
insertion
d)
deletion
5.

DNA mutations that do not cause any functional change in the protein product are known as:

a)

nonsense mutations

b)

non-synonymous/missense mutations

c)

antisense mutations

d)

synonymous/silent mutations

6.

Mutations can be:

a)

Harmful

b)

Beneficial

c)

Neutral

d)

All of the Above

7.
Why are insertion and deletion mutations so harmful?
a)

They change all of the codons following the mutation, which changes the amino acid sequence

b)
They insert things that an organism doesn't need.
c)
They often delete things that organisms need.
d)
Insertion and deletions are not any more harmful than substitution mutations.
8.

Mutations that result in the generation of a stop codon are called:

a)

Antisense mutations

b)

Missense mutations

c)

Nonsense mutations

d)

Termination mutations

9.

Mutations that occur during DNA replication are called:

a)

Spontaneous mutations

b)

Induced mutations

c)

Natural mutations

d)

Replicative mutations

10.

Causes of induced mutations include:

a)

radiation

b)

chemicals

c)

viruses

d)

all of the above

11.

Which types of mutations can be inherited?

a)

Somatic mutations

b)

Germline mutations

c)

Spontaneous mutations

d)

Induced mutations

12.
Identify the mutation in the picture.
a)
Inversion
b)
Deletion
c)
Duplication
d)
Translocation
13.
Identify the mutation in the picture.
a)
Inversion
b)
Duplication
c)
Deletion
d)
Translocation
14.
Identify the mutation in the picture.
a)
Deletion
b)
Inversion
c)
Duplication
d)
Translocation
15.
What process occurs during meiosis that can result in chromosomal disorders?
a)
crossing over
b)
non-disjunction
c)
anaphase I
d)

independent assortment

16.

Non-disjunction involving the sex chromosomes occurs during spermatogenesis and produces two kinds of sperm, XY and O (no sex chromosomes). If the different sperm fertilise a normal egg, what are the possible genotypes produced?

a)

XX AND XY

b)

XYY AND XO

c)

XXY AND XO

d)

YY AND XO