WorksheetsBiochem Block 4 Review questions
Total questions: 11
Worksheet time: 6mins
Which of the following factor decreases insulin secretion?
Epinephrine
Amino Acids (Arginine, Lysine, Leucine)
Fatty Acids
Glucose-dependent insulinotropic peptide
During the absorptive state which of the following statement are true:
all tissues are using glucose as an energy source
the insulin: glucagon ration is elevated
anabolic processes are favoured
all of there above
non of the above
Which of the following factor increases insulin secretion?
Somatostatin
Increase Blood glucose
Norepinephrine
All of the above
All the following statements are correct regarding the Insulin receptors, EXCEPT:
The insulin receptor is a tetramer consisting of two alpha and two beta subunits
The alpha subunits are located on the extracellular side and interact with insulin
The beta subunits span the cell membrane and have intrinsic tyrosine kinase activity
Binding of insulin to insulin receptors leads to dissociation of the tetrameric complex
Insulin acts on the liver, adipose tissue, and muscle to decrease blood glucose concentration. Identify the correct statements from the following:
Increases uptake of glucose into the target tissue by upregulating glucose transporter GLUT4.
Increases promote the formation of glycogen and downregulation of glycogenolysis glycogen breakdown.
Decreases gluconeogenesis and activating glycolysis in the liver
All of the above
Which of the following types of enzyme regulation occurs first after a meal?
substrate availability
allosteric effectors
covalent modification
change in enzyme synthesis
none of the above
Insulin promotes glycogen synthesis by..................................................................?
Increasing activity of glucokinase
Increasing activity of glycogen synthetase
Increasing uptake of glucose into the cells
All of the above
What happens to the LDL receptors once they've been internalised? Select one of the following:
They're removed the vesicle and returned to the cell surface
They're removed the vesicle and destroyed
They're removed the vesicle and altered into different receptors
Identify the false statement regarding the control and secretion of insulin:
High blood glucose- the potent stimulator of insulin secretion, activates GLUT2
Increased glucose oxidation in islet cells increases intracellular ATP
High Intracellular ATP opens the ATP-sensitive potassium ion channel
Depolarization opens voltage-gated ion channel calcium channel
Increased Cytosolic Calcium ion causes exocytosis and release of insulin
Glucagon is a peptide hormone. It is secreted by the alpha cells of the pancreatic islets. The primary target for glucagon action is the liver, where its action is mediated by..............................................?
cAMP
cGMP
Nuclear receptors
None of the above
Glucagon regulates blood glucose by following, EXCEPT:
Increasing liver glycogenesis
Increasing liver gluconeogenesis
Increasing liver glycolysis
All of the above
