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CC2LEC PRELIM REVIEWER

Total questions: 60

Worksheet time: 30mins

Name
Class
Date
1.

In order to maintain electrical neutrality in the RBC, bicarbonate leaves the RBC and enters the plasma through an exchange mechanism with which of the following?

a)

Chloride

b)

Potassium

c)

Sodium

d)

Magnesium

2.

1. Aldose determination is highly significant in the differentation of muscle conditions involving differentation of neuromuscular atrophy fro, myopathy

2. The assay reaction involves oxidation of NADH

a)

1st T 2nd F

b)

1st F 2nd T

c)

Both T

d)

Both F

3.

Among the ff enzymes exhibits the least tissue specificity?

a)

Acid Phosphatase

b)

Alk phosphatase

c)

Creatine kinase

d)

Lactate dehydrogenase

e)

All

4.

Among the ff enzymes, which one is identified as the only clinically analyzed enzyme using urine sample?

a)

Amylase

b)

LDH

c)

CK

d)

Aspartate aminotransferase

5.

Among the ff electrolytes, which one has the lowest conc in the sera of healthy patients?

a)

Mg

b)

Cl

c)

Bicarbonate

d)

None

6.

1. In the deter. Of enzyme activity using a purified enzyme as the reagent, the enzyme must be in excess conc.

2. This will allow the reaction to follow first-order kinetics

a)

1st T, 2nd F

b)

1st F, 2nd T

c)

Both T

d)

Both F

7.

Which among the ff enzyme classification is characterized by the reaction involving the coenzyme NAD/ NADH?

a)

Isomerase

b)

Oxidoreductase

c)

Hydrolases

d)

Transferases

8.

The highest elevation of ALP occurs in which of the following conditions?

a)

Rickets

b)

Paget’s Disease

c)

Obstructive jaundice

d)

Hyper parathyroidismK

9.

Which among the following pairs of electrolytes and the color of flame produce is correct?

a)

Sodium: orange

b)

Potassium: yellow

c)

Potassium: Violet

d)

Sodium: Violet

10.

Which electrolyte is significantly involved in the transmission of nerve impulses?

a)

Magnesium

b)

Potassium

c)

Sodium

d)

Chloride

11.

Which among the following condition/s will result to an increased activity of Creatine Kinase?

1. Uremic myopathy

2. Myasthenia gravis

3. Muscular dystrophy

4. Poliomyelitis

a)

All

b)

1,2, and 3

c)

2 and 4

d)

1 and 3

12.

1. Samples for lactate determination should be collected preferably without the use of tourniquet.

2. Prolonged application if tourniquet decrease lactate concentration due to venous stasis.

a)

1st statement is true, but 2nd

statement is false

b)

1st statement is false, but 2nd statement is true

c)

Both T

d)

Both F

13.

Which of the following statements is true of Calcitonin?

1. It inhibits osteoclastic bone resorption.

2. It is secreted.

3. It lowers both Calcium and

phosphorus.

4. Increased calcium secretion the

parafollicular cells of the thyroid gland

a)

All

b)

1,2, and 3

c)

1 and 3

d)

4 only

e)

NOTA

14.

Which among the following enzymes will be increased in relation to skeletal muscle disease?

a)

AST, CK and LDH

b)

AST, ALT and ALP

c)

5’ nucleosidase, MPO and Aldolase

d)

Aldolase and CK

e)

None

15.

Which among the following can cause an elevation in the concentration of phosphates?

1. Overmedication with vitamin D

2. Excessive intake of laxatives

3. Decrease in renal excretion.

4. Patients with lymphoblastic leukemia

a)

ALL

b)

1,2 and 3

c)

1 and 3

d)

2 and 4

e)

None

16.

What is the expected potassium concentration in serum sample compared to a plasma sample?

a)

Higher in concentration

b)

Lower in concentration

c)

No significant difference

d)

You cannot be determined

17.

Which among the following PATHOLOGIC condition/s will result to amylase activity? an increased

1. Acute pancreatitis

2. Diabetic ketoacidosis 3. Renal insufficiency

4. Macroamylasemia

a)

1 and 3

b)

ALL

c)

1, 2 and 3

d)

1 only

e)

None

18.

Identification of hepatocellular damage can be best assessed using which among the following enzymes?

a)

ALT and AST

b)

LAPS nucleotide and OCT

c)

GGT and ALP

d)

All

e)

None

19.

Fill in the blanks:

In the different enzyme assay, the kinetic method measures enzyme______while an endpoint assay measures enzyme________.

a)

Activity: Activity

b)

Activity:Concentration

c)

Concentration:Activity

d)

Concentration:Concentration

e)

None

20.

Which among the following statements about enzyme is NOT TRUE?

a)

Enzyme activity data must be integrated together with other information

b)

Measurements of rate provides the best data

c)

Normal enzyme activity results are useful indicators

d)

There is no true organ-specific eye

21.

Given the following data, what will be the expected osmolality of the patient? Sodium: 150 mEq/L

Glucose: 80 mg/dl

BUN: 18 mg/dl

a)

Within the normal range

b)

Below the normal range

c)

Above the normal range

d)

Cannot be determined

22.

Which among the following conditions will result to an elevation of gamma-glutamyl transferase?

1. Liver damage due to chronic alcoholism

2. Drug hepatotoxicity

3. Cholestasis

4. Sclerosing cholangitis

a)

1 only

b)

All

c)

1,3 and 4

d)

1, 2 and 3

e)

None

23.

What is the most common cause

Of hyperkalemia in hospitalized patients?

a)

Therapeutic potassium administration

b)

IM injection

c)

Renal failure

d)

Severe dehydration

e)

All

24.

This enzyme catalyzes the reaction which is significant in protecting the cell against damage from products of oxidative phosphorylation. It is can also be determined in conjunction with other acute phase Reactants

a)

Trypsin

b)

Leucine aminopeptidase

c)

Myeloperoxidase

d)

Glucose-6-phosphate dehydrogenase

e)

None

25.

Which among the following enzyme/s is/are considered to be the most sensitive enzyme index of primary muscle involvement?

a)

LDH

b)

AST

c)

CK

d)

Aldolase

26.

Which among the following statements is/are true about Macro CK 1?

a)

It can be found in severely ill patients in oligomeric mitochondrial for CK

b)

No pathological significance of but it can cause increased CK activity

c)

It is a complex type of CX bound to an IgE molecule

d)

All

27.

What will be the effect of Vitamin D in the calcium metabolism?

1. Increased absorption from the intestine

2. Increased reabsorption from the kidney tubule

3. Increased sorption from bone

4. Increased uptake by the osteocytes

a)

2 and 4

b)

1, 2 and 3

c)

1 and 3

d)

All

e)

None

28.

Which among the ff compounds act as the activator for Amylase

a)

Chloride

b)

Zinc

c)

Magnesium

d)

Pyridoxal Phosphate

e)

None

29.

Which among the following is considered to be the major lactate dehydrogenase isoenzyme in serum sample of healthy individuals?

a)

LD 2

b)

LD 1

c)

LD. 4

d)

LD 5

30.

Sarah, 25-year-old patient, was experiencing diarrhea and excretion of fatty stool due to pancreatic insufficiency. What will be the expected result if Sarah has undergone determination of Lipase activity?

a)

Normal

b)

Dec

c)

Inc

d)

No effect on lipase act

31.

The Regan isoenzyme is analogous with the alkaline phosphatase that originates in which of the following tissue/organ?

a)

Done

b)

Intestine

c)

Liver

d)

Placenta

32.

Which among the following is the recommended method for Cholinesterase determination?

a)

Kalow and Genest method

b)

Elman method

c)

Michel method

d)

All

33.

Mane Juan, a 35-year-old farmer, was rushed to the hospital due to pesticide poisoning. One of the tests requested by the physician is determination of cholinesterase activity. What will be the expected result?

a)

Variable

b)

Inc

c)

Dec

d)

No significant changes

34.

Which among the following conditions will result to physiological elevation of serum alkaline phosphatase activity?

1. Osteitis deformans

2. Hyperparathyroidism

3. Diabetes

4. Third trimester of pregnancy

a)

All

b)

1, 2 and 3

c)

1 and 2

d)

4 only

e)

None

35.

A hospitalized patient who is experiencing neuromuscular irritability should be tested for which among the following compound?

1. Calcium

2. Sodium

3. Potassium

4. Chloride

a)

2 and 4

b)

All

c)

1 and 3

d)

1 only

36.

All of the following compounds are considered as a coenzyme, EXCEPT:

1. NADH

2. Pyridoxal Phosphate

3. NADPH

4. Magnesium

a)

1,2 and 3

b)

2 and 4

c)

All

d)

1 and 3

e)

None

37.

1)Ornithine carbamoyl transferase is a specific marker of liver function that is routinely beingn measured in the laboratory.

2) It catalyzes the relation related to the Krebs-Henseleit cycle.

a)

1st statement is true but 2nd statement is false

b)

1st statement is false but 2nd statement is true

c)

Both True

d)

Both False

38.

Which among the following is NOT true about the regulation of potassium?

a)

Propranolol also affects potassium

concentration by promoting its entry

into the cells

b)

Na-K pump can be inhibited in cases where there is depletion of oxygen

c)

Insulin can also affect the potassium concentration by promoting its entry into skeletal muscles and the liver

d)

The Na-KATPase pump is an active transport mechanism that allows transport of potassium into the cell

e)

None

39.

The following are all conditions associated with hypochloremia with sodium depletion.

EXCEPT:

1. Prolonged vomiting

2. Addison's disease

3. Salt-losing nephritis

4. Increased gastric juice secretion

a)

1 and 3

b)

All

c)

2 and 4

d)

None

40.

A 30-year-old male patient was tested for GGT and ALP activity. The result has shown a Normal GGT level with an increased ALP level. Which among the following condition should be considered?

a)

Spurt

b)

Hepatotoxicity

c)

Bone disease

d)

Obstructive jaundice

e)

None

41.

Which among the following methods of determination for Calcium concentration is considered to be the reference method?

a)

Use of metallochromic indicators

b)

Ion selective electrode using cellophane membrane

c)

Clark and collip method

d)

Atomic absorption spectrophotometry

e)

All

42.

Among the following enzymes, which will be significantly affected by hemolysis?

a)

LDH

b)

ACP

c)

CK

d)

AAT

43.

Which of the ff has an effect on plasma calcium levels?

a)

Inorganic phosphate

b)

Iron

c)

Potassium

d)

Sodium

44.

A reciprocal relationship exists between which of the ff electrolytes?

a)

Sodium and potassium

b)

chloride aNd sodium

c)

Calcium and phosphorus

d)

Calcium and magnesium

45.

All of the following body fluids can be used to measure chloride, EXCEPT:

a)

Serum

b)

Sweat

c)

Urine

d)

None

46.

A blood sample from a patient who has thrombocytosis was sent to the laboratory for potassium determination, the potassium level would expected to be:

a)

Remain in normal level

b)

Dec

c)

Elevated

d)

None

47.

The Fiske-Subbarrow method for inorganic phosphorus is based upon its reaction with what substance?

a)

Ammonium molybdate

b)

Mercuric nitrate

c)

Oxalic acid

d)

P-nitrophenyl

48.

Which among the electrolytes is most likely to be ordered in addition to serum calcium to determine the cause of tetany?

a)

Magnesium

b)

Phsophate

c)

Sodium

d)

Vitamin d

e)

None

49.

Factors which influence the distribution of potassium within cells, EXCEPT:

a)

Insulin

b)

Catecholamines

c)

Hypoxia

d)

All

e)

None

50.

Which of the ff would be consistent with primary hypoparathyroidism?

a)

High calcium high inorganic phosphorus

b)

Low calcium low inorganic phosphorus

c)

Low calcium high inrogamic phosphorus

d)

High calcium low inorganic phosphorus

51.

Which of the ff statements is NOT TRUE about chloride?

a)

Can shift from the extracellular plasma to the intracellular fluid of the RBC

b)

Measured in serum, urine and sweat

c)

Main anion of the ECF

d)

Unable to be reabsorbed by active

transport

52.

Patients who excessively clench their first before venipuncture would have an increased level of which of the following electrolytes?

a)

Chloride

b)

Calcium

c)

Sodium

d)

Potassium

53.

What specimen preparation is commonly used to perform the alkaline phosphatase isoenzyme determination?

a)

Serum is divided into 2 aliquots; one is frozen and the other one is refrigerated

b)

Serum is divided into 2 aliquots; one

is heated at 56C and the other is

unheated

c)

No preparation necessary since the assay uses EDTA plasma

d)

Protein free nitrate is Prepared fest

54.

All of the ff are causes of hypokalemia, EXCEPT

a)

Dec renal excretion

b)

Alkali

c)

GI loss

d)

NoneK

55.

Which percentage of total serum calcium is non-diffusible protein bound?

a)

40-50%

b)

80-90%

c)

90-80%

d)

10-30%

56.

In the ortho-cresol phthalein complex one method for calcium determination, what substance is added in order to prevent interference with magnesium?

a)

EGTA

b)

8-hydroxyauinoline

c)

EDTA

d)

Arsenal dye

57.

The regulation of calcium and phosphorus metabolism is accomplished by which of the following glands?

a)

Adrenal gland

b)

parathyroid gland

c)

Pituitary gland

d)

Thyroid gland

58.

Percentage of the ionized calcium in the blood

a)

10%

b)

40%

c)

30%

d)

50@

59.

Quantitation of Na" and K" by ion- selective is the standard method because:

a)

Dilution is required for flame photometry

b)

Due to absence of internal standard of advances in clinical chemistry

c)

Of advances in electrochemistry

d)

There is no lipoprotein interferences

60.

A patient with the following test result is seen in

1. Serum Calcium-Increased

2. Serum Phosphate-Decreased

3. Parathyroid Hormone Increased

a)

Steatorrhea

b)

Hypoparathyroidism

c)

Nephrosis

d)

Hyperparathyroidism