WorksheetsCC2LEC PRELIM REVIEWER
Total questions: 60
Worksheet time: 30mins
In order to maintain electrical neutrality in the RBC, bicarbonate leaves the RBC and enters the plasma through an exchange mechanism with which of the following?
Chloride
Potassium
Sodium
Magnesium
1. Aldose determination is highly significant in the differentation of muscle conditions involving differentation of neuromuscular atrophy fro, myopathy
2. The assay reaction involves oxidation of NADH
1st T 2nd F
1st F 2nd T
Both T
Both F
Among the ff enzymes exhibits the least tissue specificity?
Acid Phosphatase
Alk phosphatase
Creatine kinase
Lactate dehydrogenase
All
Among the ff enzymes, which one is identified as the only clinically analyzed enzyme using urine sample?
Amylase
LDH
CK
Aspartate aminotransferase
Among the ff electrolytes, which one has the lowest conc in the sera of healthy patients?
Mg
Cl
Bicarbonate
None
1. In the deter. Of enzyme activity using a purified enzyme as the reagent, the enzyme must be in excess conc.
2. This will allow the reaction to follow first-order kinetics
1st T, 2nd F
1st F, 2nd T
Both T
Both F
Which among the ff enzyme classification is characterized by the reaction involving the coenzyme NAD/ NADH?
Isomerase
Oxidoreductase
Hydrolases
Transferases
The highest elevation of ALP occurs in which of the following conditions?
Rickets
Paget’s Disease
Obstructive jaundice
Hyper parathyroidismK
Which among the following pairs of electrolytes and the color of flame produce is correct?
Sodium: orange
Potassium: yellow
Potassium: Violet
Sodium: Violet
Which electrolyte is significantly involved in the transmission of nerve impulses?
Magnesium
Potassium
Sodium
Chloride
Which among the following condition/s will result to an increased activity of Creatine Kinase?
1. Uremic myopathy
2. Myasthenia gravis
3. Muscular dystrophy
4. Poliomyelitis
All
1,2, and 3
2 and 4
1 and 3
1. Samples for lactate determination should be collected preferably without the use of tourniquet.
2. Prolonged application if tourniquet decrease lactate concentration due to venous stasis.
1st statement is true, but 2nd
statement is false
1st statement is false, but 2nd statement is true
Both T
Both F
Which of the following statements is true of Calcitonin?
1. It inhibits osteoclastic bone resorption.
2. It is secreted.
3. It lowers both Calcium and
phosphorus.
4. Increased calcium secretion the
parafollicular cells of the thyroid gland
All
1,2, and 3
1 and 3
4 only
NOTA
Which among the following enzymes will be increased in relation to skeletal muscle disease?
AST, CK and LDH
AST, ALT and ALP
5’ nucleosidase, MPO and Aldolase
Aldolase and CK
None
Which among the following can cause an elevation in the concentration of phosphates?
1. Overmedication with vitamin D
2. Excessive intake of laxatives
3. Decrease in renal excretion.
4. Patients with lymphoblastic leukemia
ALL
1,2 and 3
1 and 3
2 and 4
None
What is the expected potassium concentration in serum sample compared to a plasma sample?
Higher in concentration
Lower in concentration
No significant difference
You cannot be determined
Which among the following PATHOLOGIC condition/s will result to amylase activity? an increased
1. Acute pancreatitis
2. Diabetic ketoacidosis 3. Renal insufficiency
4. Macroamylasemia
1 and 3
ALL
1, 2 and 3
1 only
None
Identification of hepatocellular damage can be best assessed using which among the following enzymes?
ALT and AST
LAPS nucleotide and OCT
GGT and ALP
All
None
Fill in the blanks:
In the different enzyme assay, the kinetic method measures enzyme______while an endpoint assay measures enzyme________.
Activity: Activity
Activity:Concentration
Concentration:Activity
Concentration:Concentration
None
Which among the following statements about enzyme is NOT TRUE?
Enzyme activity data must be integrated together with other information
Measurements of rate provides the best data
Normal enzyme activity results are useful indicators
There is no true organ-specific eye
Given the following data, what will be the expected osmolality of the patient? Sodium: 150 mEq/L
Glucose: 80 mg/dl
BUN: 18 mg/dl
Within the normal range
Below the normal range
Above the normal range
Cannot be determined
Which among the following conditions will result to an elevation of gamma-glutamyl transferase?
1. Liver damage due to chronic alcoholism
2. Drug hepatotoxicity
3. Cholestasis
4. Sclerosing cholangitis
1 only
All
1,3 and 4
1, 2 and 3
None
What is the most common cause
Of hyperkalemia in hospitalized patients?
Therapeutic potassium administration
IM injection
Renal failure
Severe dehydration
All
This enzyme catalyzes the reaction which is significant in protecting the cell against damage from products of oxidative phosphorylation. It is can also be determined in conjunction with other acute phase Reactants
Trypsin
Leucine aminopeptidase
Myeloperoxidase
Glucose-6-phosphate dehydrogenase
None
Which among the following enzyme/s is/are considered to be the most sensitive enzyme index of primary muscle involvement?
LDH
AST
CK
Aldolase
Which among the following statements is/are true about Macro CK 1?
It can be found in severely ill patients in oligomeric mitochondrial for CK
No pathological significance of but it can cause increased CK activity
It is a complex type of CX bound to an IgE molecule
All
What will be the effect of Vitamin D in the calcium metabolism?
1. Increased absorption from the intestine
2. Increased reabsorption from the kidney tubule
3. Increased sorption from bone
4. Increased uptake by the osteocytes
2 and 4
1, 2 and 3
1 and 3
All
None
Which among the ff compounds act as the activator for Amylase
Chloride
Zinc
Magnesium
Pyridoxal Phosphate
None
Which among the following is considered to be the major lactate dehydrogenase isoenzyme in serum sample of healthy individuals?
LD 2
LD 1
LD. 4
LD 5
Sarah, 25-year-old patient, was experiencing diarrhea and excretion of fatty stool due to pancreatic insufficiency. What will be the expected result if Sarah has undergone determination of Lipase activity?
Normal
Dec
Inc
No effect on lipase act
The Regan isoenzyme is analogous with the alkaline phosphatase that originates in which of the following tissue/organ?
Done
Intestine
Liver
Placenta
Which among the following is the recommended method for Cholinesterase determination?
Kalow and Genest method
Elman method
Michel method
All
Mane Juan, a 35-year-old farmer, was rushed to the hospital due to pesticide poisoning. One of the tests requested by the physician is determination of cholinesterase activity. What will be the expected result?
Variable
Inc
Dec
No significant changes
Which among the following conditions will result to physiological elevation of serum alkaline phosphatase activity?
1. Osteitis deformans
2. Hyperparathyroidism
3. Diabetes
4. Third trimester of pregnancy
All
1, 2 and 3
1 and 2
4 only
None
A hospitalized patient who is experiencing neuromuscular irritability should be tested for which among the following compound?
1. Calcium
2. Sodium
3. Potassium
4. Chloride
2 and 4
All
1 and 3
1 only
All of the following compounds are considered as a coenzyme, EXCEPT:
1. NADH
2. Pyridoxal Phosphate
3. NADPH
4. Magnesium
1,2 and 3
2 and 4
All
1 and 3
None
1)Ornithine carbamoyl transferase is a specific marker of liver function that is routinely beingn measured in the laboratory.
2) It catalyzes the relation related to the Krebs-Henseleit cycle.
1st statement is true but 2nd statement is false
1st statement is false but 2nd statement is true
Both True
Both False
Which among the following is NOT true about the regulation of potassium?
Propranolol also affects potassium
concentration by promoting its entry
into the cells
Na-K pump can be inhibited in cases where there is depletion of oxygen
Insulin can also affect the potassium concentration by promoting its entry into skeletal muscles and the liver
The Na-KATPase pump is an active transport mechanism that allows transport of potassium into the cell
None
The following are all conditions associated with hypochloremia with sodium depletion.
EXCEPT:
1. Prolonged vomiting
2. Addison's disease
3. Salt-losing nephritis
4. Increased gastric juice secretion
1 and 3
All
2 and 4
None
A 30-year-old male patient was tested for GGT and ALP activity. The result has shown a Normal GGT level with an increased ALP level. Which among the following condition should be considered?
Spurt
Hepatotoxicity
Bone disease
Obstructive jaundice
None
Which among the following methods of determination for Calcium concentration is considered to be the reference method?
Use of metallochromic indicators
Ion selective electrode using cellophane membrane
Clark and collip method
Atomic absorption spectrophotometry
All
Among the following enzymes, which will be significantly affected by hemolysis?
LDH
ACP
CK
AAT
Which of the ff has an effect on plasma calcium levels?
Inorganic phosphate
Iron
Potassium
Sodium
A reciprocal relationship exists between which of the ff electrolytes?
Sodium and potassium
chloride aNd sodium
Calcium and phosphorus
Calcium and magnesium
All of the following body fluids can be used to measure chloride, EXCEPT:
Serum
Sweat
Urine
None
A blood sample from a patient who has thrombocytosis was sent to the laboratory for potassium determination, the potassium level would expected to be:
Remain in normal level
Dec
Elevated
None
The Fiske-Subbarrow method for inorganic phosphorus is based upon its reaction with what substance?
Ammonium molybdate
Mercuric nitrate
Oxalic acid
P-nitrophenyl
Which among the electrolytes is most likely to be ordered in addition to serum calcium to determine the cause of tetany?
Magnesium
Phsophate
Sodium
Vitamin d
None
Factors which influence the distribution of potassium within cells, EXCEPT:
Insulin
Catecholamines
Hypoxia
All
None
Which of the ff would be consistent with primary hypoparathyroidism?
High calcium high inorganic phosphorus
Low calcium low inorganic phosphorus
Low calcium high inrogamic phosphorus
High calcium low inorganic phosphorus
Which of the ff statements is NOT TRUE about chloride?
Can shift from the extracellular plasma to the intracellular fluid of the RBC
Measured in serum, urine and sweat
Main anion of the ECF
Unable to be reabsorbed by active
transport
Patients who excessively clench their first before venipuncture would have an increased level of which of the following electrolytes?
Chloride
Calcium
Sodium
Potassium
What specimen preparation is commonly used to perform the alkaline phosphatase isoenzyme determination?
Serum is divided into 2 aliquots; one is frozen and the other one is refrigerated
Serum is divided into 2 aliquots; one
is heated at 56C and the other is
unheated
No preparation necessary since the assay uses EDTA plasma
Protein free nitrate is Prepared fest
All of the ff are causes of hypokalemia, EXCEPT
Dec renal excretion
Alkali
GI loss
NoneK
Which percentage of total serum calcium is non-diffusible protein bound?
40-50%
80-90%
90-80%
10-30%
In the ortho-cresol phthalein complex one method for calcium determination, what substance is added in order to prevent interference with magnesium?
EGTA
8-hydroxyauinoline
EDTA
Arsenal dye
The regulation of calcium and phosphorus metabolism is accomplished by which of the following glands?
Adrenal gland
parathyroid gland
Pituitary gland
Thyroid gland
Percentage of the ionized calcium in the blood
10%
40%
30%
50@
Quantitation of Na" and K" by ion- selective is the standard method because:
Dilution is required for flame photometry
Due to absence of internal standard of advances in clinical chemistry
Of advances in electrochemistry
There is no lipoprotein interferences
A patient with the following test result is seen in
1. Serum Calcium-Increased
2. Serum Phosphate-Decreased
3. Parathyroid Hormone Increased
Steatorrhea
Hypoparathyroidism
Nephrosis
Hyperparathyroidism
