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QC2.M3.L2&L3

Total questions: 40

Worksheet time: 7mins

Name
Class
Date
1.

A method which depends upon the diffusion of an antibiotic from a vertical layer through a solidified agar.

a)

KIRBY-BAUER METHOD

b)

AGAR WELL METHOD

c)

CYLINDER PLATE METHOD

d)

DISK DIFFUSION METHOD

2.

A test that determines the uniformity in net content of semisolids.

a)

PARTICULATE MATTER TEST

b)

LEAKER TEST

c)

MINIMUM FILL TEST

d)

CLARITY TEST

3.

The biological indicator used in determining the efficiency of sterilization using an autoclave.

a)

BACILLUS STEAROTHERMOPHILUS

b)

BACILLUS CEREUS

c)

BACILLUS ANTHRACIS

d)

BACILLUS SUBITILIS

4.

The official method of determining the sterility of IV solutions that is recognized by the USP and FDA.

a)

DIRECT INOCULATION METHOD

b)

DIRECT TRANSFER METHOD

c)

USE OF BIOLOGICAL INDICATORS

d)

MEMBRANE FILTRATION METHOD

5.

The biological indicator used in determining the efficiency of sterilization using an oven.

a)

BACILLUS STEAROTHERMOPHILUS

b)

BACILLUS CEREUS

c)

BACILLUS ANTHRACIS

d)

BACILLUS SUBITILIS

6.

A test that determines the presence of microorganisms.

a)

CLARITY TEST

b)

PYROGEN TEST

c)

LEAKER TEST

d)

STERILITY TEST

7.

Biological assays using microorganisms.

a)

PYROGEN TEST

b)

MINIMUM FILL ASSAY

c)

MICROBIAL ASSAY

d)

CLARITY TEST

8.

The Carr’s index is used in determining what property of granules?

a)

COMPRESSIBILITY

b)

FLUIDITY

c)

VISCOSITY

d)

POROSITY

9.

What is being measured in agar well method?

a)

TURBIDITY

b)

ACID PRODUCTION

c)

CLOUDINESS

d)

ZONE OF INHIBITION

10.

Test organism for Penicillin G

a)

Klebsiella pneumoniae

b)

Staphylococcus aureus

c)

Micrococcus luteus

d)

Escherichia coli

11.

An in-vitro test for determining pyrogens.

a)

RABBIT TEST

b)

BACTERIAL ENDOTOXIN TEST

c)

QFRIR TEST

d)

ALL OF THESE

12.

LAL test is applicable in the determination of _________.

a)

FUNGAL ENDOTOXIN

b)

BACTERIAL ENDOTOXIN

c)

VIRAL ENDOTOXIN

d)

PROTOZOAL ENDOTOXIN

13.

Products of growth of microorganisms that produce fever.

a)

PYROGENS

b)

PARTICULATES

c)

POISONS

d)

ALL OF THESE

14.

A biochemical assay that detects and quantify antigen-antibody binding.

a)

RIA

b)

LAL

c)

ELISA

d)

QFRIR

15.

Test organism for Streptomycin

a)

Escherichia coli

b)

Staphylococcus aureus

c)

Micrococcus luteus

d)

Klebsiella pneumoniae

16.

An in-vivo test for determining pyrogens.

a)

LAL TEST

b)

BACTERIAL ENDOTOXIN TEST

c)

RABBIT TEST

d)

ALL OF THESE

17.

Ethylene oxide is used in the sterilization of __________.

a)

RUBBER

b)

METAL

c)

GLASS

d)

PLASTIC

18.

The major requirement for an analyst performing clarity test.

a)

10/10 VISION

b)

15/15 VISION

c)

20/20 VISION

d)

25/25 VISION

19.

The method used in determining the sterility of medical devices, non-filterable sterile products and parenteral emulsions.

a)

DIRECT INOCULATION METHOD

b)

DIRECT TRANSFER METHOD

c)

USE OF BIOLOGICAL INDICATORS

d)

MEMBRANE FILTRATION METHOD

20.

LAL is obtained from __________ (scientific name).

a)

LIMULUS POLYPHEMUS

b)

LIMULUS AMOEBIASUS

c)

LIMULUS POLYNEUS

d)

LIMULUS PLANTARUM

21.

A method used in determining leaking collapsible tubes.

a)

PARTICULATE MATTER TEST

b)

CLASSICAL BLOTTING PAPER METHOD

c)

LAL METHOD

d)

TURBIDIMETRIC METHOD

22.

A test that determines the concentration or potency of the antibiotic that will inhibit the growth of susceptible microorganisms.

a)

STERILITY TEST FOR VITAMINS

b)

MICROBIAL ASSAY FOR VITAMINS

c)

MICROBIAL ASSAY FOR ANTIBIOTICS

d)

STERILITY TEST FOR ANTIBIOTICS

23.

The test organism representing the aerobes used in sterility testing.

a)

CLOSTRIDIUM SPECIES

b)

STAPHYLOCOCCUS SPECIES

c)

STREPTOCOCCUS SPECIES

d)

BACILLUS SPECIES

24.

Test organism for Amphotericin B.

a)

Staphylococcus aureus

b)

Escherichia coli

c)

Klebsiella pneumoniae

d)

Saccharomyces cerevisiae

25.

Test organism for Chloramphenicol.

a)

Staphylococcus aureus

b)

Escherichia coli

c)

Klebsiella pneumoniae

d)

Saccharomyces cerevisiae

26.

Test organism for microbial assay of niacin/nicotinamide.

a)

LACTOBACILLUS PLANTARUM

b)

LACTOBACILLUS LEICHMANII

c)

BOTH OF THESE

d)

NONE OF THESE

27.

The culture medium used for cultivation of aerobes in sterility testing.

a)

NUTRIENT MEDIUM

b)

LOEFFLER'S MEDIUM

c)

SOYBEAN CASEIN DIGEST MEDIUM

d)

FLUID THIOGLYCOLLATE MEDIUM

28.

The dye used in leaker test.

a)

METHYLENE BLUE

b)

METHYL RED

c)

AMARANTH GREEN

d)

SUDAN RED

29.

A parenteral is declared pyrogenic if the total rise in temperature of the 8 rabbits is ________.

a)

LESS THAN 3.3C

b)

MORE THAN 3.3 C

c)

EQUAL TO OR GREATER THAN 3.3C

d)

EQUAL TO 3.3C

30.

A method that measures the frictional forces in granules using a fixed cone.

a)

STATIC METHOD

b)

KINETIC METHOD

c)

BOTH OF THESE

d)

NONE OF THESE

31.

The test organism representing the anaerobes used in sterility testing.

a)

CLOSTRIDIUM SPECIES

b)

MYCOBACTERIUM SPECIES

c)

BACILLUS SPECIES

d)

STAPHYLOCOCCUS SPECIES

32.

A test that determines the presence of fever causing substances.

a)

STERILITY TEST

b)

CLARITY TEST

c)

LEAKER TEST

d)

PYROGEN TEST

33.

Microbial assay for antibiotics which uses antibiotic impregnated disc.

a)

AGAR CUP METHOD

b)

CYLINDER PLATE METHOD

c)

AGAR WELL METHOD

d)

DISK DIFFUSION METHOD

34.

LAL stands for __________.

a)

LINULUS AMOEBOCYTE LYSATE

b)

LIMULUS AMOEBOCYTE LYSIS

c)

LIMULUS AMOEBOCYTE LYSATE

d)

ALL OF THESE

35.

A parenteral is declared pyrogenic if the temperature rise in individual rabbit is _________.

a)

EQUAL TO OR GREATER THAN 0.5C

b)

EQUAL TO OR GREATER THAN 0.4C

c)

EQUAL TO OR GREATER THAN 0.7C

d)

EQUAL TO OR GREATER THAN 0.6C

36.

A preparatory stage done prior to QFRiR test.

a)

LAL TEST

b)

SHAM TEST

c)

PYROGEN TEST

d)

RABBIT TEST

37.

Test organism for microbial assay of cyanocobalamin.

a)

LACTOBACILLUS PLANTARUM

b)

LACTOBACILLUS LEICHMANII

c)

BOTH OF THESE

d)

NONE OF THESE

38.

A test that determines improperly sealed ampules.

a)

PYROGEN TEST

b)

CLARITY TEST

c)

STERILITY TEST

d)

LEAKER'S TEST

39.

The culture medium used for cultivation of anaerobes in sterility testing.

a)

FLUID THIOGLYCOLLATE MEDIUM

b)

NUTRIENT BROTH

c)

SOYBEIN CASEIN DIGEST MEDIUM

d)

TRYPTICASE SOY BROTH

40.

A particulate matter test whose drawback is the inability to distinguish a shadow cast by a particle from a shadow cast by a bubble.

a)

USE OF COULTER COUNTER

b)

USE OF ELECTRONIC PARTICULATE COUNTER

c)

USE OF MEMBRANE FILTER