WorksheetsAntihyperlipidaemics
Total questions: 10
Worksheet time: 6mins
Which of these is a long acting statin?
Lovastatin
What interaction occurs between statins and grapefruit juice?
Reduced absorption
Enzyme inhibition
Increased excretion of statin
Which is a common adverse effect of fibrates?
Gallstones
Gout
Atherosclerosis
Bronchoconstriction
Where does evolocumab act?
HMG CoA reductase
PCSK9
NPC1L1
PPAR Gamma
Which of these are the mechanisms of action for bile acid binding resins?
Reduced cholesterol absorption from GI tract
Reduced excretion of cholesterol
Increased hepatic conversion of cholesterol to bile acids
Inhibition of HMG CoA reductase
Which are the mechanisms of fibrate action?
Activation of ppar gamma
Increased LDL release from hepatocyte
Reduced VLDL secretion by liver
Reduced lipid absorption from gut
Which are examples of fibrates?
Nicotinamide
Gemfibrozil
Bezafibrate
Clofibrate
Which substrate is involved in statin action?
acetylCoA
Mevalonate
pyruvate
apolipoprotein
Which are common adverse effects of statins?
Myalgia
Hepatotoxicity
Bradycardia
The mechanism of statin action includes
Inhibition of HMG CoA reductase
Upregulation of LDL receptors
Increased LDL reuptake
Increased triglycerides
