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WorksheetsHematology 1: Iron Kinetics
Total questions: 20
Worksheet time: 11mins
Iron is transported in plasma via:
Transferrin
Divalent Metal Transporter 1
Heme Transporter
Duodenal Cytochrome B
None
The total iron-binding capacity (TIBC) of the serum is an indirect measure of which iron-related protein?
Ferric Ions
Ferritin
Transferrin
None
What is the major metabolically available storage form of iron in the body?
Hemosiderin
Heme Iron
Non-Heme Iron
Ferritin
None
What membrane-associated protein in enterocytes transports non-heme
ferrous ions from the intestinal lumen into the enterocytes?
Heme Transporter
Divalent Metal Transporter 1
Ferroportin
None
Iron is transported out of macrophages, hepatocytes, and enterocytes by what membrane protein?
Ferroprotein
Transferrin
Transferrin Receptor
Ferroportin
None
Below are several of the many steps in the process from absorption and transport of iron to incorporation into heme.
Place them in proper order.
i. Transferrin picks up ferric iron.
ii. Iron is transferred to the mitochondria.
iii. DMT1 transports ferrous iron into the enterocyte.
iv. Ferroportin transports iron from enterocyte to plasma.
v. The transferrin receptor transports iron into the cell.
iii, ii, iv, i, v
v, iv, i, ii, iii
ii, i, v, iii, iv
iii, iv, i, v, ii
The transfer of iron from the enterocyte into the plasma is REGULATED by:
Transferrin
Ferroportin
Hepcidin
Hephaestin
None
What is the percent transferrin saturation for a male patient with total serum iron of 63 mg/dL and TIBC of 420 mg/dL?
Is the answer within the reference value?
15%, outside RV
0.15%, inside RV
0.15% outside RV
15%, inside RV
Ferroportin is a basolateral protein of:
Hepatocyte
Erythrocyte
Macrophage
Enterocyte
When the body has adequate stores of iron, the hepatocytes sense that and will increase the production of hepcidin.
Iron exported from the enterocyte into the blood is ferrous and must be converted to the ferric form for transport in the blood.
First Statement is True, Second Statement is False
Second Statement is True, First Statement is False
Both Statements are Correct
Both Statements are Incorrect
Ferritin and Hemosiderin in Macrophages and Hepatocytes of Storage Compartment accounts for:
10% Total Body Iron,
0.36g of Iron Content
16% Total Body Iron,
0.68g of Iron Content
68% Total Body Iron,
0.36g of Iron Content
18% Total Body Iron,
0.67g of Iron Content
a Female patient with a Total Iron Binding Capacity (TIBC) of 75 umol/L is suggestive of having:
NBSB Disorder
Sideroblastic Anemia
Iron-Deficiency Anemia
Thalassemia
20-80% of the Bone Marrow Normoblasts have Visible Iron with 1-3 Inclusions.
Erythrocytes and Reticulocytes in Peripheral Blood should not have visible iron.
First Statement is True, Second Statement is False
Second Statement is True, First Statement is False
Both Statements are Correct
Both Statements are Incorrect
70% of total body iron is transported in _______ state to Heme portion of Hemoglobin
Cationic trivalent
[Ferrous (Fe3+)]
Cationic trivalent
[Ferrous (Fe3+)]
Cationic bivalent
[Ferric (Fe2+)]
Cationic bivalent
[Ferrous (Fe2+)]
Converts non-heme ferric ions to ferrous ions:
Divalent Metal Transporter 1
Duodenum-Specific Cytochrome B-like Protein
Hephaestin
Heme oxygenase
Converts ferrous ions to ferric ions:
Divalent Metal Transporter 1
Duodenum-Specific Cytochrome B-like Protein
Hephaestin
Heme oxygenase
________ in Hepcidin Production enables Ferroportin to transport Iron out.
increase
decrease
A 12-hour fasting, non-hemolyzed, serum specimen is used for:
Percent Saturation
Total Iron Binding Capacity
Prussian Blue Stain
Serum Iron
In order to enter Enterocytes, the reduction of Heme Iron (Fe2+ to Fe3+) is facilitated by:
Duodenum-Specific Cytochrome B-like Protein
Heme Transporter
Heme Oxygenase
None,
Invalid Question
The degradation of Heme in an Enterocyte is facilitated by:
Heme Oxidase
Heme Oxygenase
Heme Transporter
None,
Invalid Question
