WorksheetsClass #1 Quiz!
Total questions: 10
Worksheet time: 6mins
Of all Dementia cases, Alzheimer's Disease makes up...
20-40%
60-80%
45-55%
10-30%
Where is the mutation that leads to amyloid-beta plaques?
BACE1
presinilin
n-terminus
alpha secretase
How was the enhanced glutamate release probability at the CAI-CA3 synapse measured?
Western blot
Paired-pulse facilitation
Induced vesicle fusion
Low frequency stimulation
The bundle of CA3 axons extending toward CA1 neurons is called the...
Shaffer collateral
Mossy fibers
Perforant Path
After protein electrophoresis, which proteins remain at the top?
Heavier proteins
Lighter proteins
What happens when we add amyloid beta to a brain slice, then block NMDARs!
Tau hyperphosphorylation is reduced back to control levels
mGluRs allow for tau hyperphosphorylation to continue
Tau hyperphosphorylation increses by ~10%
No change occurs
What happens when you INCREASE the release probability at a synapse? (select all that apply)
LTP increases
LTP decreases
LTD increases
LTD increases
What conditions are required in order for an NMDAR to open? (select all that apply)
Glutamate binds
Postsynaptic hyperpolarization
Glycine binds
Glutamine binds
Postsynaptic depolarization
A ____________ was used to cancel out the effects of Aβ's increase on glutamate release probability
Fluorescent antibody
mGluR blocker
Low-n oligomer
Voltage-gated Ca2+ channel blocker
Incubation of hippocampal slices in Aβ led to a(n) (a) in hyperphosphorylated tau.
