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WorksheetsDose and dose response
Total questions: 9
Worksheet time: 5mins
The quantity of a substance administered to an individual over a period of time or in several individual doses is known as the:
administered dose
absorbed dose
total dose
Fractionation of a total dose so that the total amount administered is given over a period of time usually results in:
decreased toxicity
increased toxicity
The usual dosage unit that incorporates the amount of material administered or absorbed in accordance with the size of the individual over a period of time is:
PPM/hour
mg/kg/day
kg/100 lb/week
The dose at which a toxic effect is first encountered is called the:
median toxic dose
absorbed dose
threshold dose
The dose-response relationship helps a toxicologist determine:
whether exposure has caused an effect
the threshold dose
the rate of increasing effect with increasing dose levels
all of the above
The Therapeutic Index (TI) is used to:
Compare the therapeutically effective dose to the toxic dose of a pharmaceutical agent
Calculate the lethal dose level for different pharmaceuticals
Compare the lethal dose to the therapeutically effective dose of a pharmaceutical agent
The Margin of Safety (MOS) of a drug is the:
Amount of a pharmaceutical that can be given before toxicity first appears
Difference between the Effective Dose to 50% of the population (ED50) and the Toxic Dose to 50% of the population (TD50)
Ratio of the Toxic Dose to 1% of the population (TD01) to the Effective Dose to 99% of the population (ED99)
The No Observed Adverse Effect Level (NOAEL) is the:
Lowest dose at which there was no observed toxic or adverse affect
Highest dose at which there was no observed toxic or adverse effect
Highest dose at which there was an observed adverse effect
The Lowest Observed Adverse Effect Level (LOAEL) is the:
Lowest dose at which there was an observed toxic or adverse effect
Lowest dose at which there was no observed toxic or adverse effect
Highest dose at which there was an observed adverse effect
