WorksheetsQuiz 10 (Pathologic calcification + cell aging )
Total questions: 10
Worksheet time: 5mins
Which of the following is true about dystrophic calcification?
It occurs in normal tissues.
It is always associated with hypercalcemia.
It occurs in areas of necrosis or tissue damage.
It is caused by excessive vitamin D intake.
Metastatic calcification is commonly associated with which condition?
Local tissue necrosis
Chronic inflammation
Hyperparathyroidism
Ischemia
What is the key microscopic feature of dystrophic calcification?
Deposition of calcium in intact tissue
Psammoma bodies in necrotic areas
Calcium deposition in the walls of healthy arteries
Amorphous, basophilic calcium deposits on necrotic cells
Which of the following is NOT a cause of metastatic calcification?
Hypercalcemia due to renal failure
Vitamin D intoxication
Elevated parathyroid hormone levels
Chronic infection
In metastatic calcification, where does calcium typically deposit?
Necrotic tissues
Normal blood vessels and lungs
Healing scars
Areas of chronic inflammation
Which cellular mechanism is most closely associated with aging?
Increased telomerase activity
Accumulation of somatic DNA damage
Enhanced mitochondrial biogenesis
Increased synthesis of growth factors
Telomere shortening during cell division is primarily mediated by which enzyme deficiency?
DNA polymerase
Telomerase
Helicase
RNA polymerase
Which of the following proteins is associated with the regulation of cellular senescence?
p53
Myc
Ras
Akt
What is the effect of caloric restriction on aging, according to studies mentioned in Robbins?
Accelerates telomere shortening
Decreases mitochondrial oxidative stress
Reduces expression of DNA repair enzymes
Increases metabolic rate
Lipofuscin accumulation in aging cells is indicative of which process?
Increased protein synthesis
Failure of proteasomal degradation
Free radical-induced lipid peroxidation
Enhanced autophagy
