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WorksheetsCancer Genes
Total questions: 21
Worksheet time: 14mins
Name
Class
Date
1.
Which is an example of a tumor suppressor gene?
a)
apoptosis
b)
proto-oncogenes
c)
p53
d)
oncogenes
2.
Normal cell division is prevented by...
a)
Proto-oncogenes
b)
oncogenes
3.
p53 activates which of the following?
a)
Tumor suppressor genes
b)
cell cycle
c)
DNA repair proteins
d)
uncontrolled cell division
4.
Proto-oncogenes can mutate into...
a)
oncogenes
b)
tumor suppressor genes
c)
DNA repair proteins
5.
p53 triggers which of the following to occur?
a)
apoptosis
b)
cell cycle
c)
cancer
d)
uncontrolled cell division
6.
Which of the following is a dominant single mutation to cause cancer?
a)
p53 protein
b)
proto-oncogenes
c)
DNA repair proteins
7.
Which of the following needs a double mutation to cause cancer?
a)
p53 protein
b)
proto-oncogenes
c)
DNA repair proteins
8.
________________________ is a process of recognizing defective cells, letting them die, and replacing with normal cells.
a)
Mitosis
b)
Apoptosis
c)
Interphase
d)
Metaphase
9.
What is occurring in this picture?
a)
Translation
b)
Replication
c)
Translocation
d)
Transcription
10.
Protein kinases activate other relay proteins by adding a(n) ____ to them.
a)
phosphate
b)
ATP molecule
c)
cAMP
d)
GTP
11.
Why do cancer cells not respond properly to cell signals and controls?
a)
damage to a cell’s cytoplasm
b)
damage to a cell’s sister chromatids
c)
damage to a cell’s DNA
d)
damage to a cell’s wall and membrane
12.
Uncontrolled cell division is stopped by...
a)
tumor suppressor genes
b)
oncogenes
13.
Which is an example of a tumor suppressor gene?
a)
apoptosis
b)
proto-oncogenes
c)
p53
d)
oncogenes
14.
Normal cell division is regulated by...
a)
Proto-oncogenes
b)
oncogenes
15.
Normal cell division is prevented by...
a)
Proto-oncogenes
b)
oncogenes
16.
What kind of a gene is p53?
a)
Proto-Oncogene
b)
Oncogene
c)
Tumor Suppressor Gene
d)
Proto-Tumor Suppressor Gene
17.
Damage to which type of genes is the most common cause of cancer?
a)
Oncogenes
b)
Tumor Suppressor Genes
c)
Proto-Oncogenes
d)
Apoptosis-Inducing Genes
18.
potential to cause cancer but needs some alterations in its genetic make-up
a)
oncogene
b)
proto-oncogene
c)
risk factor
d)
cell cycle
19.
A ligand binds to a receptor on the surface of a cell. This binding leads to the activation of a G-protein, ultimately resulting in a phosphorylation cascade. What occurs within the cell that results in the activation of the G-protein?
a)
Binding of ATP to the G-protein instead of ADP.
b)
Binding of GTP to the G-protein instead of GDP.
c)
De-phosphorylation of the G-protein.
d)
Dimerization of the protein.
20.
50% of all human tumors contain p53 mutants.
a)
True
b)
False
21.
If p53 cannot bind DNA
a)
it cannot activate its target genes to arrest cell divison
b)
it converts to RNA
c)
it cannot trigger apoptosis
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