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WorksheetsImmune System Quiz
Total questions: 30
Worksheet time: 5mins
Which of the following is a primary lymphoid organ?
Spleen
Lymph node
Bone marrow
MALT
What is the major function of B cells?
Phagocytosis
Antibody production
Killing virus-infected cells
Producing histamine
Which type of immune cell is the first to respond to infection and is most abundant in the blood?
Basophils
Eosinophils
Neutrophils
Macrophages
Which of the following cells is considered a professional antigen-presenting cell?
Neutrophil
Natural Killer cell
Dendritic cell
Eosinophil
Which immune cell uses the NADPH oxidase complex to generate reactive oxygen species?
Eosinophils
NK cells
Neutrophils
Macrophages
Which statement best describes T-helper (CD4+) cell function?
They kill tumor cells directly
They suppress autoimmune responses
They help activate B cells, macrophages, and CD8+ T cells
They produce antibodies
Which statement about NK cells is incorrect?
They are part of adaptive immunity
They kill virus-infected cells
They are innate immune cells
They can kill tumor cells
Which feature is most characteristic of neutrophils?
Bilobed nucleus and eosinophilic granules
Circular nucleus and smooth surface
Multilobed nucleus with ROS production capability
Large round nucleus and antigen presentation
Which of the following best describes a function of the immune system?
Producing hormones for metabolism
Regulating blood pressure
Distinguishing self from non-self to prevent autoimmunity
Synthesizing red blood cells
What is the central component of all complement activation pathways?
C1
C3
C5
C9
What is the function of the Membrane Attack Complex (MAC)?
Opsonization
Neutralizing viruses
Inducing cell lysis
Activating T cells
What complement protein acts as a key opsonin to enhance phagocytosis?
C1q
C3a
C5a
C3b
The alternative pathway is continuously active at low levels due to:
Microbial antigen binding
Antibody interaction
Spontaneous C3 hydrolysis
Activation by cytokines
HLA genes are located on which chromosome?
3
6
11
17
Which cells express Class I HLA molecules?
Only T cells
B cells and dendritic cells only
All nucleated cells
Red blood cells
What type of T cell recognizes peptides presented by HLA Class II molecules?
CD8+ T cells
Natural killer cells
CD4+ T cells
B cells
HLA genes are inherited in which pattern?
Autosomal recessive
Codominant
X-linked dominant
Mitochondrial
Class II HLA molecules present peptides derived from:
Proteins in the cytosol
DNA antigens
Extracellular proteins
Nuclear RNA
Class II HLA molecules are expressed by all EXCEPT:
Dendritic cells
Macrophages
B cells
Neutrophils
Why is HLA polymorphism important in populations?
Reduces autoimmune diseases
Ensures uniform immune response
Increases susceptibility to pathogens
Allows population-level resistance to diverse pathogens
What is the primary function of NK cells?
Produce antibodies
Kill infected host cells
Present antigen to T cells
Phagocytose bacteria
Which cells are responsible for producing antibodies?
Cytotoxic T cells
Macrophages
B lymphocytes
NK cells
What is the key feature that distinguishes adaptive from innate immunity?
Rapid response
Pattern recognition
Specificity and memory
Use of phagocytes
Which receptor is involved in antibody-dependent cellular cytotoxicity (ADCC) by NK cells?
CD8
CD16
CD28
CD40
Which cytokine promotes the differentiation of CD4+ T cells into Th1 cells?
IL-4
IL-12
IL-17
IL-5
Which antibody isotype is most abundant in mucosal secretions?
IgG
IgE
IgM
IgA
What characterizes a T-dependent B cell activation?
No memory cell formation
Limited to polysaccharides
Requires T cell help and co-stimulation
Results in only IgM production
Which cytokines are primarily secreted by Th2 cells?
IFN-γ and IL-2
IL-4, IL-5, and IL-13
IL-17 and IL-22
TGF-β and IL-10
What feature distinguishes Th17 cells from Th1 and Th2 cells?
Secrete IL-4
Promote IgE class switching
Recruit neutrophils and induce inflammation
Suppress immune responses
Which of the following statements about T regulatory cells is TRUE?
They enhance B cell antibody production
They promote Th17 differentiation
They produce IL-10 and TGF-β to suppress immune responses
They are cytotoxic to infected cells
