WorksheetsExam 3 Review Session
Total questions: 28
Worksheet time: 18mins
Which of the following is an adverse effect of Caspofungin (Cancidas)? SATA
Hypokalemia
Increased excretion of protein in urine
Fever and Flushing
Hypermagnesemia
Increased Serum Potassium levels
Which of the following statements about Terbinafine (Lamisil) is CORRECT? SATA
It is metabolized by 1A2, 3A4, and 2C9
It has a terminal half-life of 200-400 hours
It is highly plasma protein-bound (~99%)
Food slightly increases its AUC
~40% of the administered dose is eliminated through the Renal System
Which of the following statements about Voriconazole (VFend) is FALSE? SATA
It is ineffective against Aspergillus
It is effective against Fusarium Solani
It is ineffective against Scedosporium Species
The maintenance dose is 4 mg/kg IV Q12H
The maintenance dose is 200 mg PO QID
Which of the following combination regimens is LIKELY to be used in the treatment of Breast Cancer? SATA
VATH Regimen
CISCA Regimen
IMF Regimen
ACTH Regimen
FECD Regimen
Which of the following adverse effects of Amphotericin B suggests the occurrence of a Hemorrhagic Episode? SATA
Dyspepsia
Hematuria
Epistaxis
Melena
Hemoptysis
Which of the following statements about Amphotericin B is CORRECT? SATA
It can be given Intraarticularly, Intraventricularly, and Intra-arterially
It is slowly excreted through the renal system
It can be complexed with Deoxycholate
It is well distributed into the Synovium and into the Peritoneum
It is not metabolized and it can be complexed with DMPC and DMPG
Which of the following should the Pharmacist advise the Medical Team about when using Lamisil (Terbinafine) for long-term therapy? SATA
Perform a Renal Function Test
Advise the patient to avoid acidic food and caffeine
Advise the patient to avoid concurrent ingestion of alcohol
Perform a CBC
Perform a Liver Function Test
Abafungin (Abasol) inhibits which of the following? SATA
Delata-7,8-osomerase
Glucan Synthase
C24-methyltransferase
Squalene Epoxidase
C14-alpha-demethylase
Which of the following is NOT a component of the M2 Regimen that is used for Multiple Myeloma? SATA
Prednisone
Semustine (Methyl CCNU)
Vincristine
Cyclophosphamide
Alkeran (Melphalan)
Which of the following is MOST LIKELY to be used to treat Primary Macroglobulinemia?
Melphalen
Chlorambucil
Bisulfan
Carmustene
Mitoxantrone
Which of the following is an indication of Trabectedin (Yondelis)? SATA
Acute Granulocytic Leukemia
Chronic Granulocytic Leukemia
Leiomyosarcoma
Neuroblastoma
Metastatic Liposarcoma
Which of the following statements about Cyclophosphamide (Cytoxan) is FALSE? SATA
It is activated in the liver
It has a PPB of ~56%
It is administered IV, IP, and IT
It has a half-life of 6-7 days
It is mainly excreted through the Renal System
Which drug is used to treat Pancreatic Insulinoma?
Streptozocin
Kyprolis
Carumustine
Pomalyst
Which of the following is a Proteasome Inhibitor that is combined with Dexamethasone for the treatment of Multiple Myeloma?
Emplicty
Kyprolis (Carfilzomib)
Pomalyst
Darzelex
Carmustine
What are the 4 agents that are included in the CHAD Regimen used to treat Ovarian Cancer? SATA
Cyclophosphamide (Cytoxan)
Hexymethymelamine
Cisplatin
Doxorubicin (Adriamycin)
Which of the following is an indication of Itraconazole (Sporanox)? SATA
Blastomycosis
Candidiasis
Cutaneous Leishmaniasis
Cryptococcus
Sporotrichosis
Which of the following is a Squalene Epoxidase Inhibitor? SATA
Aftate (Tolnafate)
Loceryl (Amorolfine)
Penlac (Ciclopirox)
Halotex (Haloprogin)
Butenafine (Lotrim Ultra, Mentax)
Nystatin can be used to manage which of the following conditions? SATA
Vaginal Moniliasis
Candidiasis of the Esophagus
Candidal Paronychia
Candidiasis of the Tongue
Athlete's Foot
Which enzyme do Azoles inhibit?
C14-alpha-demthylase
CYP3A4
CYP2C9
None of the above
What is the enzyme that converts Lanosterol to ergosterol?
Demethyl Lanosterol
Ethyl
Methyl
None of the above
Which of the following will interfere with the process of mitosis in the fungus?
AmBisome
Ancobon
Grisactin (Griseofulvin)
Candicidan
5-FC
Which of the following statements about Brexefemme (Ibrexafungerp) is TRUE? SATA
It is highly plasma protein-bound
It is mostly excreted through the urine
It has a half-life of ~20 Hours
It is administered at a dosage of 300 mg PO QAM and PO QPM x 5 days
It is metabolized by CYP450
WOTF is classified as an Imidazole Antifungal Agent? SATA
Luliconazole (Luzu)
Cytoconazole
Isoconazole (Travogen)
Miconazole (Monistat, Desenex)
Efinaconazole (Jublia)
Which drug will you sue to treat Chromoblastomycosis?
Ancobon (Flucytosine)
Luliconazole (Luzu)
Cytoconazole
Miconazole (Monistat)
What is the Maintenance Dose of Rezafungin?
200 mg IV QWeek
100 mg IV QD
150 mg IV QD
50 mg IV QD
What is the Maintenance Dose of Anidulafungin?
50 mg IV QD
200 mg IV Week
100 mg IV QD
150 mg IV QD
What is the Maintenance Dose of Micafungin?
200 mg IV QWeek
50 mg IV QD
100 mg IV QD
150 mg IV QD
What is the Maintenance Dose of Caspofungin?
200 mg IV Week
50 mg IV QD
100 mg IV QD
150 mg IV QD
