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inorganic and organic chem

Total questions: 43

Worksheet time: 22mins

Name
Class
Date
1.

group attached to the acy amino group is called?

a)

A. phenoxyethyl

b)

B. Isoxazoyl

c)

C. Amidazole

d)

E. benzyl

e)

E. Mythoxyphenyl

2.

Halogen substituents are best place in what position?

a)

A. 1,2 substitution

b)

B. 1,3 subtitution

c)

C. 1,4 substitution

d)

D. both A and B

e)

E. Both A and C

3.

This antibiotic is primarily indicated for what type of infection

a)

A. kiebsiella

b)

B. Enterobacter

c)

C. Psudomonas

d)

D. Staphylococci

e)

E. Streptococci

4.

Adding more 1 chloride atoms in the structure confers what modification on the pharmacokinetic profile

a)

A. Liberation

b)

B. Absorption

c)

C. Distribution

d)

D. Metabolism

e)

E. Excretio

5.

what is the role of chloride atom in the structure?

a)

A. increase the susceptibility to penicillinase

b)

B. incresing the plasma concentration

c)

C. acid resistance property

d)

D. increase in parenteral absorption

e)

E. increase in oral absorption

6.

preservatives like parabens increase their preservative property by:

a)

A. Reducing the parent compound

b)

B. Decreasing molecular weight

c)

C. Attaching a halogen to the parent compound

d)

D. substituting the parent compound with a lipophilic group

e)

E. Increasing the molecular weight

7.

Sodium pump is an example of

a)

A. enzyme linked tyrosine kinase receptor

b)

B. G-Protein coupled receptor

c)

C. Ion-channel

d)

D. Gene-transcription-linked receptor

e)

E. None of the above

8.

This is an approach in drug discovery whrein there is already an existing drug that can be used to identify a new lead compound

a)

A. Random Screening

b)

B. Molecular Docking

c)

C. Parent compound modication

d)

D. Biotechnology techniques

e)

E . Rational Drug Design

9.

Azeotropic distillation of benzene is done in what concentration of ethanol?

a)

A. 95%

b)

B. 70%

c)

C. 50%

d)

D. 99%

e)

E. 10%

10.

Radical reactions may also produceed using this reagent hydrogen peroxide

a)

A. Bromine water

b)

B. Hydrogen peroxide

c)

C. Nitric acid

d)

Sodium oxalate

e)

potassium bitartrate

11.

What is the reagent needed for the frat maction?

a)

A. NaOH/Gxidizing agers

b)

B. CH, CRACNH

c)

C. HNO3/H2SO4

d)

D. NaOH/Reducing agent

12.

when a carbonyl group react with a secondary amine, what will be the resulting product?

a)

A. Imine

b)

B. Amide

c)

C. Tertiary amine

d)

D. Enamine

e)

E. secondary amine

13.

Addition of hydrogen molecule to an alkene is catalyzed by what metal?

a)

A. Silver

b)

B. Palladium

c)

C. Berrylium

d)

D. Gallium

e)

E. Osmium

14.

Methoxybenzene is also known as

a)

A. Anisole

b)

B. Toluene

c)

C. Aniline

d)

D. Xylene

e)

E. Anethole

15.

which of the following compounds can be use to synthesize primary alcohols?

a)

A. Propane

b)

B. Formaldehyde

c)

C. 3-chloropentane

d)

D. Acetone

e)

E. Ethanamine

16.

Which of the following cephalosporin is excreted in bile?

a)

A. Cefixime

b)

B. Cefotaxime

c)

C. Ceftriaxone

d)

D. Moxalactam

e)

E. Loracarbef

17.

Preservatives use for molds

a)

A. Ethylpraben

b)

B. Methylparaben

c)

C. Butylparaben

d)

D. Propylparaben

e)

E. Isopropylparaben

18.

Which is true about drug absorption?

l. for weekly acidic drug, it must be in its unionized form

ll. for weekly acidic drug, it must be in its ionized form

lll. for weakly basic drug, it must be in its unionized form

lV. for weakly basic drug, it must be in its unionized form

a)

A. l,ll,ll

b)

B. l and lll

c)

C. ll and lV

d)

D. lll and lV

e)

E. l and lll

19.

this anti-convulsion compound is susceptible to what metabolic pathway?

a)

A. Aromatic hydroxylation

b)

B. Methylation

c)

C. Sulfate conjugation

d)

D. Oxidative deamination

e)

E. GSH conjugation

20.

which of the following will confer resistance againts beta lactamases when synthesizing analogs of penicillin.

a)

A. Halogen

b)

B. Ring Deactivators

c)

C. Electron Chawing Group

d)

D. Bulky group

e)

E. Ring activators

21.

what functional group is being modified if formulation into a salt is needed?

a)

A. Amide

b)

B. Carboxylic acid

c)

C. Carbonyl

d)

D. Alkyl

e)

E. 225 g

22.

what is the functional group attached to the beta lactam ring?

a)

A. Aryl amide

b)

B. Acyl amide

c)

C. Polyamide

d)

D. Carboxyamide

e)

E. Phenylamide

23.

which of the following is true on ideal antiseptics?

l. low toxicity

ll. sustained and rapid lethal action against microorganisms

lll. High surface tension

lV. Non- irritating and non-allergenic

a)

A. l,ll,lV

b)

B. lll only

c)

C. l,ll,lll,lV

d)

D. ll and lll

e)

E. lll and lV

24.

Aztreonam can elevate this enzyme

a)

A. Creatinine kinase

b)

B. Pyruvate

c)

C. Alanine aminotransferase

d)

D. creatinine phosphokinase

e)

E. Thrombin

25.

The functional group in the box is an additional chemical entity of this drug that makes a prodrug,what is the probable reason of adding that moeity to the parent compound?

a)

A. increase in absorption

b)

B. Increase in palatability

c)

C. Decrease in protein binding

d)

D. increase in solubility

e)

E. Decrease in absorption

26.

when the drug will undergo metabolism,which of the following enzymes will act on it?

a)

A. ligases

b)

B. Hydrolases

c)

C. Transferases

d)

D. isomerases

e)

E. Lyases

27.

When the drug is acted upon by different enzymes during its metabolism, what is/are the products?

a)

A. Alcohol

b)

B. Amide

c)

C. Carboxylic acid

d)

D. A and B

e)

E. B and C

28.

The compound use to identify the partition coefficient in-vitro

a)

A. Tert-butyl alcohol

b)

B. Phenol

c)

C. Isopentyl Alcohol

d)

D. N-octanol

e)

E. Benzyl Alcohol

29.

Isoniazid is metabolized by humans principally by:

a)

A. acetylation

b)

B. Deaminition

c)

C. Methylation

d)

D. Conjugation

e)

E. Oxidation

30.

The total affinity of the ligand to its receptor

a)

A. intrinsic activity

b)

B. Agonistic activity

c)

C. Avidity

d)

D. antagonistic activity

e)

E. Agonistic affinity

31.

Dimethylbenzene is also known as

a)

A. anisole

b)

B. Aniline

c)

C. Xylene

d)

D. Phenol

e)

E. Ethylene

32.

The type of bond that exists in the structure

a)

A. Amide bond

b)

B. Ether bond

c)

C. Tert-amine bond

d)

D. Ester bond

e)

E. Glycosidic bond

33.

This compound may produce the followeing effect, except

a)

A. Vasoconstriction

b)

B. Bradycardia

c)

C. Metallic taste

d)

D. CNS depression

e)

E. Sodium channel blockage

34.

The compound is an example of what class of drug?

a)

A. Anesthetic

b)

B. Barbiturate

c)

C. Sedatives

d)

D. Analgesic

e)

E. Anxiolytics

35.

This compound is derived from the destructive distillation of castor oil and it is use as keratolytic agent

a)

A. Salicylic acid

b)

B. Undecylanic acid

c)

C. Benzoic acid

d)

D. Chrysarobin

e)

E. Propionic acid

36.

The following are example of G protein coupled receptor, except

a)

A. GABA receptors

b)

B. Beta-2 receptors

c)

C. Muscarinic receptors

d)

D. Alpha-1 receptors

e)

E. Beta 1 receptor

37.

DNA alkylating agent binds to its target by means of what bond?

a)

A. Hydrogen bonding

b)

B. Electrostatic bonding

c)

C. Hydrophobic bonding

d)

D. ionic bonding

e)

E. Covalent bonding

38.

C3H6O can be a/an

a)

A. ketone

b)

B. Ether

c)

C. aldehyde

d)

D. both A and B

e)

E. both A and C

39.

zovirax is effective againts the stain of

a)

A. varicella

b)

B. HSV

c)

C. Vesicular Stomatitis virus

d)

D. all of the above

e)

E. none of the above

40.

The acetylation of morphine yields.

a)

A. codeine

b)

B. Papaverine

c)

C. Noscapine

d)

D. Heroin

e)

E. Thebaine

41.

Primidone is prodrug that is converted to

a)

A. Entacapone

b)

B. Diazepam

c)

C. Phenobarbital

d)

D. Carbamazepine

e)

E. Aminophylline

42.

Diuretics that acts on the thick ascending limb (TAL)/

a)

A. Indapamide

b)

B. Furosemide

c)

C. Acetazolamide

d)

D. amiloride

e)

E. Mannitol

43.

This is a butyrophenone derived antipsychotic agent that is frequently used for tourette's syndrome

a)

A. Clozaril

b)

B. Haldol

c)

C. Thorazine

d)

D. Daxolin

e)

E. Zoloft

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