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Pharm Final Quiz 4 (Antimicrobial Agents)

Total questions: 105

Worksheet time: 53mins

Name
Class
Date
1.

About ___% of antibiotic prescriptions in 2020 were unnecessary.

a)

30

b)

10

c)

50

d)

70

2.

Older adults and malnourished patients have less resistance to infection.

a)

True

b)

False

3.

What is a potential consequence of overusing anti-infective agents?

a)

Drug resistance

b)

Improved immunity

c)

Faster recovery from all diseases

d)

Decreased risk of infection

4.

Antibacterial agents can either kill bacteria or inhibit bacterial growth.

a)

True

b)

False

5.

Bacteriostatic drugs:

a)

A) Kill bacteria

b)

B) Inhibit bacterial growth

c)

C) Both A and B

d)

D) None of the above

6.

Bactericidal drugs:

a)

A) Kill bacteria

b)

B) Inhibit bacterial growth

c)

C) Both A and B

d)

D) None of the above

7.

Depending on dose, drugs may have both bacteriostatic and bactericidal effects.

a)

True

b)

False

8.

Narrow spectrum antibiotics are primarily effective against ___ type of organism.

a)

one

b)

all

c)

multiple

d)

unknown

9.

Broad spectrum antibiotics are effective against a wide variety of microbes.

a)

True

b)

False

10.

Fill in the blank: Superinfections are common with _______ spectrum antibiotics.

a)

broad

b)

narrow

c)

extended

d)

limited

11.

Which of the following is a common cause of superinfections?

a)

Narrow spectrum antibiotics

b)

Broad spectrum antibiotics

c)

Antivirals

d)

Vaccines

12.

Fill in the blank: Natural flora of the body is _______ by broad spectrum antibiotics.

a)

destroyed

b)

increased

c)

protected

d)

stimulated

13.

Which of the following is NOT a common bacterial superinfection?

a)

A) Yeast infections

b)

B) Clostridium Difficile Colitis

c)

C) Influenza

d)

D) Both A and B

14.

Fill in the blank: Severe cases of Clostridium Difficile Colitis are treated with PO antibiotics such as _______ or vancomycin or FMT.

a)

metronidazole

b)

amoxicillin

c)

azithromycin

d)

ceftriaxone

15.

To prevent superinfections, patients should ingest ________, yogurt, or probiotics.

a)

buttermilk

b)

orange juice

c)

soda

d)

potato chips

16.

Overuse and inappropriate use of antibiotics _______ the emergence of antibiotic resistance.

a)

exacerbates

b)

prevents

c)

delays

d)

eliminates

17.

Which of the following is recommended for effective infection treatment?

a)

Treat contamination, not infection

b)

Target specific pathogens

c)

Avoid selecting correct medications

d)

Ignore infectious disease experts

18.

The use of the strongest agents, such as vancomycin, should be limited to a last resort because:

a)

overuse can lead to antibiotic resistance

b)

they are less effective than weaker agents

c)

they are the cheapest option available

d)

they are always the first line of treatment

19.

Fill in the blank: C&S testing can be done to determine ________.

a)

sensitivity

b)

temperature

c)

pressure

d)

color

20.

When bacteria is 'sensitive' to a drug, what happens to the organism?

a)

The organism is killed or inhibited by the drug.

b)

The organism becomes stronger.

c)

The organism is unaffected by the drug.

d)

The organism multiplies rapidly.

21.

Which of the following is NOT a method to prevent transmission of infection?

a)

Hygiene and isolation precautions

b)

Vaccinations

c)

Limiting invasive devices

d)

Using contaminated samples

22.

Penicillins are effective against which type of bacteria?

a)

Only gram-negative

b)

Most gram-positive and some gram-negative

c)

Only broad spectrum

d)

Only gram-positive

e)

Most gram-negative and some gram-positive

23.

Penicillins/PCNs have a ____ risk of toxicity.

a)

High

b)

Moderate

c)

Low

d)

Unknown

24.

What is the reported incidence of penicillin allergy in the US population?

a)

1-2%

b)

5-10%

c)

15-20%

d)

25-30%

25.

The real incidence of penicillin allergy is likely much ______ than reported.

a)

lower

b)

higher

c)

longer

d)

shorter

26.

Which of the following is NOT an example of a penicillin?

a)

Penicillin G

b)

Amoxicillin

c)

Dicloxacillin

d)

Cephalexin

27.

Methicillin is ________ marketed in the USA.

a)

no longer

b)

widely

c)

recently

d)

commonly

28.

Which of the following statements about resistance to penicillins is correct?

a)

Resistance is rare

b)

Resistance is common

c)

Resistance is never seen

d)

Resistance is only seen in viruses

29.

Staphylococcus aureus is an example of a bacteria that is no longer resistant to which penicillin?

a)

Amoxicillin

b)

Methicillin

c)

Penicillin V

d)

Dicloxacillin

30.

All penicillins, except ________, are absorbed better on an empty stomach.

a)

amoxicillin

b)

penicillin G

c)

cloxacillin

d)

ampicillin

31.

Which penicillin produces a higher rate of adverse GI effects than other penicillins?

a)

Amoxicillin

b)

Ampicillin

c)

Penicillin G

d)

Dicloxacillin

32.

Which antibiotic class is the most commonly used?

a)

Macrolides

b)

Cephalosporins

c)

Penicillins

d)

Tetracyclines

33.

Which statement describes cephalosporins the best?

a)

Broad spectrum, easy administration, safe and effective even at high doses, minimal adverse effects.

b)

Narrow spectrum, high toxicity, frequent dosing required, many drug interactions.

c)

Only effective against viruses, require complex administration, high risk of allergic reactions.

d)

Limited to topical use, ineffective at high doses, cause severe side effects.

34.

Cephalosporins are given for 90% of surgeries prior to incision for what purpose?

a)

Surgical infection prophylaxis

b)

Pain management

c)

Anesthesia induction

d)

Blood clot prevention

35.

The higher the generation number of cephalosporins, the broader the spectrum and the more likely it is to reach cerebrospinal fluid (CSF).

a)

True

b)

False

36.

What percentage of persons allergic to penicillins are also allergic to cephalosporins?

a)

1-8%

b)

10-20%

c)

20-30%

d)

30-50%

37.

If a patient has an anaphylactic history with penicillins, what should be done when administering cephalosporins?

a)

Do trial microdosing instead of full dosage at once.

b)

Administer the full dose immediately.

c)

Ignore the allergy history and proceed as usual.

d)

Switch to a higher generation cephalosporin.

e)

Switch to a different antibiotic class.

38.

Why are superinfections common with cephalosporins?

a)

Due to their broad spectrum nature.

b)

Because they are always given with steroids.

c)

Because they are only effective against viruses.

d)

Because they suppress the immune system directly.

39.

Which of the following is the oldest macrolide antibiotic? (This would be REALLY mean if she put this on the final)

a)

Azithromycin

b)

Clarithromycin

c)

Erythromycin

d)

Penicillin

40.

Macrolides are frequently prescribed if the patient has an allergy to which of the following?

a)

Cephalosporins

b)

Penicillins

c)

Tetracyclines

d)

Sulfa drugs

41.

Erythromycin should be taken with _______.

a)

food

b)

water only

c)

an empty stomach

d)

milk

42.

Azithromycin should be taken 1 hour before or 2 hours after _______.

a)

meals

b)

exercise

c)

sleep

d)

medication

43.

Clarithromycin rarely causes GI side effects and may be taken with or without food.

a)

True

b)

False

44.

Which macrolide antibiotics are considered more expensive?

a)

Erythromycin

b)

Azithromycin and Clarithromycin

c)

Penicillin

d)

Amoxicillin

45.

What serious infection can macrolides cause?

a)

Clostridium Difficile

b)

Pneumocystis Pneumonia

c)

Tuberculosis

d)

Hepatitis B

46.

Azithromycin (Z-Pak) is typically given once daily for how many days?

a)

2-3 days

b)

4-5 days

c)

7-10 days

d)

14 days

47.

The new formulation of azithromycin (Zmax) can be taken in a single dose of _______.

a)

2g

b)

500mg

c)

1g

d)

250mg

48.

Azithromycin is ridiculously over-prescribed, leading to common _______.

a)

resistance

b)

addiction

c)

allergy

d)

deficiency

49.

Which of the following is NOT an example of a fluoroquinolone antibiotic?

a)

Ciprofloxacin

b)

Levofloxacin

c)

Doxycycline

d)

Delafloxacin

50.

Fluoroquinolones are often used for which of the following conditions?

a)

Mild infections

b)

UTIs and pyelonephritis

c)

Viral infections

d)

Fungal infections

51.

Fill in the blank: Fluoroquinolones should NOT be considered first-line treatment for ______ infections.

a)

mild

b)

severe

c)

nosocomial

d)

complicated

52.

Which property is true about fluoroquinolones?

a)

Narrow spectrum

b)

Bacteriostatic

c)

Potent antibiotics

d)

Used for viral infections

53.

Which of the following is NOT an example of a tetracycline antibiotic?

a)

Tetracycline

b)

Doxycycline

c)

Minocycline

d)

Levofloxacin

54.

Fill in the blank: Tetracyclines are known for having one of the ______ spectrums of any class of antibiotics.

a)

broadest

b)

narrowest

c)

weakest

d)

shortest

55.

Which statement is true about tetracyclines?

a)

They are bactericidal

b)

They are bacteriostatic

c)

They are only used for viral infections

d)

They have a narrow spectrum

56.

Fill in the blank: ________ are the drug of choice for Rickettsial diseases (rocky mountain spotted fever, ticks, mites, lice, infected animals).

a)

Tetracyclines

b)

Penicillins

c)

Cephalosporins

d)

Macrolides

57.

Fill in the blank: Tetracyclines are the drug of choice for Chlamydia and ________.

a)

cholera

b)

tuberculosis

c)

influenza

d)

malaria

58.

Fill in the blank: Tetracyclines are the drug of choice for peptic ulcers caused by ________.

a)

Helicobacter Pylori

b)

Escherichia coli

c)

Streptococcus pneumoniae

d)

Staphylococcus aureus

59.

Fill in the blank: Tetracyclines are the drug of choice for acne when used ________ and PO.

a)

topically

b)

intravenously

c)

subcutaneously

d)

rectally

60.

Which of the following is a side effect of tetracyclines?

a)

Photosensitivity

b)

Hypertension

c)

Hyperglycemia

d)

Bradycardia

61.

Tetracyclines are contraindicated in children less than 8 years old due to the risk of irreversible discoloration of permanent teeth.

a)

True

b)

False

62.

Fill in the blank: Tetracyclines MUST be taken on an ________ stomach (EXCEPT doxycycline or minocycline).

a)

empty

b)

full

c)

crowded

d)

heavy

63.

Fill in the blank: Tetracyclines should NOT be given with milk, calcium, antacids, or ________ containing drugs.

a)

iron

b)

potassium

c)

magnesium

d)

zinc

64.

Which minerals bind with tetracyclines and block their absorption?

a)

Calcium and iron

b)

Sodium and potassium

c)

Magnesium and zinc

d)

Copper and selenium

65.

Aminoglycosides are narrow spectrum antibiotics used to treat ______ bacteria.

a)

gram-negative

b)

gram-positive

c)

anaerobic

d)

acid-fast

66.

Which of the following is NOT an example of an aminoglycoside?

a)

Gentamycin

b)

Amikacin

c)

Tobramycin

d)

Penicillin

67.

Aminoglycosides are primarily given by which routes due to poor absorption in the GI tract?

a)

IM or IV

b)

Oral

c)

Subcutaneous

d)

Topical

68.

Why is careful drug dosing important for aminoglycosides?

a)

Because they have a narrow therapeutic window.

b)

Because they are always given orally.

c)

Because they are not absorbed in the intestines.

d)

Because they are used to treat viral infections.

69.

What is the first sign of ototoxicity caused by aminoglycosides?

a)

Tinnitus

b)

Vertigo

c)

Hearing loss

d)

Nausea

70.

Ototoxicity caused by aminoglycosides is largely reversible.

a)

True

b)

False

71.

Which adverse effect of aminoglycosides is associated with excessive trough levels and includes symptoms such as proteinuria, elevated serum creatinine and BUN, and decreased eGFR?

a)

Nephrotoxicity

b)

Ototoxicity

c)

Hepatotoxicity

d)

Agranulocytosis

72.

Sulfonamides are classified as ______ spectrum antibiotics.

a)

broad

b)

narrow

c)

extended

d)

limited

73.

What are two common issues associated with sulfonamides?

a)

Frequent drug reactions and drug resistance

b)

High risk of hypoglycemia and hypertension

c)

Increased risk of viral infections and anemia

d)

Causes hyperthyroidism and weight gain

74.

SATA: What is trimethoprim/Bactrim (sulfamethoxazole/Septra) frequently used for?

a)

UTIs

b)

Herpes Simplex Viruses

c)

Otitis Media

d)

Varicella Zoster

e)

Bronchitis

75.

How much water should a patient drink when taking trimethoprim/Bactrim (sulfamethoxazole/Septra)?

a)

At least 4 oz

b)

At least 6 oz

c)

At least 8 oz

d)

At least 10 oz

76.

Silver sulfadiazine (Silvadene) is a topical agent used to treat _______.

a)

burns

b)

acne

c)

eczema

d)

psoriasis

77.

Metronidazole (Flagyl) is considered both an antibiotic AND an _______ agent.

a)

antiprotozoal

b)

antifungal

c)

antiviral

d)

antihistamine

78.

Which of the following is most commonly used to treat organisms in the GI tract, GU tract, and CNS?

a)

Trimethoprim/Bactrim

b)

Silver sulfadiazine

c)

Metronidazole/Flagyl

d)

Amoxicillin

79.

Metronidazole (Flagyl) can be used to treat trichomoniasis, IBS, and bacterial vaginosis.

a)

True

b)

False

80.

What should be avoided when taking metronidazole (Flagyl) due to the risk of an Antabuse-like reaction?

a)

Dairy products

b)

Alcohol

c)

Sunlight

d)

Caffeine

81.

Tuberculosis (TB) is caused by acid-fast bacillus, _______.

a)

Mycobacterium Tuberculosis

b)

Streptococcus pneumoniae

c)

Escherichia coli

d)

Staphylococcus aureus

82.

Mycobacterium Tuberculosis is a thick-walled bacterium.

a)

True

b)

False

83.

How is tuberculosis transmitted from one person to another?

a)

Through contaminated water

b)

Through droplets dispersed in air

c)

Through direct contact with skin

d)

Through food

84.

Is the worldwide incidence of tuberculosis increasing today?

a)

True

b)

False

85.

Attempts to isolate microorganisms in tuberculosis involve creating walls around them, known as ________.

a)

tubercles

b)

granulomas

c)

nodules

d)

plaques

e)

tumbotrons

86.

What is a key difference in drug therapy for tuberculosis compared to most other infections?

a)

Only one drug is used

b)

Polytherapy is required

c)

Treatment lasts only one week

d)

No drugs are effective

87.

Treatment for tuberculosis must continue for how many months to reach isolated microorganisms in tubercles?

a)

1-2 months

b)

3-6 months

c)

6-24 months

d)

36 months

88.

During tuberculosis treatment, using multiple drugs in different combinations lowers the potential for ________.

a)

resistance

b)

infection

c)

allergy

d)

relapse

89.

Which of the following is NOT an antitubercular agent?

a)

Isoniazid/INH

b)

Rifampin

c)

Amoxicillin

d)

Ethambutol

90.

Treatment for tuberculosis almost ALWAYS includes which two drugs?

a)

INH and rifampin

b)

Penicillin and amoxicillin

c)

Ciprofloxacin and doxycycline

d)

Azithromycin and ceftriaxone

91.

Which of the following meet the criteria for treatment of latent TB?

a)

A) Used for those who have had direct close contact with an active TB patient

b)

B) Used for those who have a positive TB skin test or blood test, but NEGATIVE chest x-ray

c)

C) Both A and B

92.

What are the two treatment options for latent TB?

a)

C) INH alone taken daily for 9 months

b)

B) INH plus rifapentine taken weekly for 3 months

c)

D) Both B and C

d)

A) INH, amoxicillin, and doxycycline for 12 months

e)

E) Both A and B

93.

INH alone is taken daily for how many months for the treatment of latent TB?

a)

9 months

b)

3 months

c)

6 months

d)

12 months

94.

Isoniazid/INH can have negative interactions with _______-rich foods.

a)

Calcium

b)

Potassium

c)

Tyramine

d)

Vitamin B12

e)

Sodium

95.

Prophylactic treatment of TB with INH is _______ in those with liver disease.

a)

recommended

b)

contraindicated

c)

required

d)

avoided if possible

96.

Fungi such as Candida are a part of human normal flora.

a)

True

b)

False

97.

SATA: Select all of the antifungals.

a)

Polyenes

b)

Azoles

c)

Echinocandins

d)

Pyrimidine Analogs

e)

Cephalosporins

98.

Nystatin is ONLY used for ______ infections.

a)

Candida

b)

Aspergillus

c)

Herpes Simplex

d)

Clostridium Difficile

99.

Viruses differ from bacteria because they contain their own DNA and RNA.

a)

True

b)

False

100.

Varicella Zoster viral infections cause _____ in children and ______ in adults.

a)

shingles, chickenpox

b)

shingles, mononucleosis

c)

chickenpox, shingles

d)

chickenpox, Epstein-Barr

101.

Herpes Simplex 1 can affect the genitals.

a)

True

b)

False

102.

The most common cause of lower respiratory infections in infants and children under 2 years old is:

a)

Varicella Zoster

b)

Influenza

c)

Pneumonia

d)

Respiratory Syncytial Virus

103.

The first-line agent for herpes viruses and Varicella Zoster is:

a)

Acyclovir

b)

Vancomycin

c)

Tetracycline

d)

Ribavirin

104.

Ribavirin is the drug of choice for hepatitis ___ when combined with ________.

a)

A, vancomycin

b)

C, interferon

c)

B, interferon

d)

D, vancomycin

105.

Pregnant nurses CANNOT administer ribavirin.

a)

True

b)

False