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Hematology Bootcamp Assessment

Total questions: 50

Worksheet time: 25mins

Name
Class
Date
1.

The major iron storage compound in the body is:

a)

Ferritin

b)

Hemoglobin

c)

Hemosiderin

d)

Transferrin

2.

A 32-year-old female presents with fatigue. CBC shows: Hb 9.5 g/dL, Hct 30%, MCV 72 fL. Serum ferritin: 8 ng/mL, Serum iron: 20 µg/dL, TIBC: 450 µg/dL, % saturation: 4%. The most likely diagnosis is:

a)

Anemia of chronic disease

b)

Iron deficiency anemia

c)

Thalassemia minor

d)

Aplastic anemia

3.

A 48-year-old male with rheumatoid arthritis has: Hb 10.8 g/dL, Hct 33%, MCV 82 fL. Serum ferritin: 300 ng/mL, Serum iron: 40 µg/dL, TIBC: 220 µg/dL, % saturation: 18%. The most likely diagnosis is:

a)

Iron deficiency anemia

b)

Anemia of chronic disease

c)

Thalassemia minor

d)

Sideroblastic anemia

4.

Which of the following anemias results from decreased synthesis of globin chains?

a)

Sideroblastic anemia

b)

Iron deficiency anemia

c)

Thalassemia

d)

Megaloblastic anemia

5.

Megaloblastic anemia is most commonly caused by deficiency of:

a)

Iron

b)

Vitamin B12 or folate

c)

Vitamin C

d)

Vitamin K

6.

Pernicious anemia is caused by:

a)

Lack of intrinsic factor

b)

Iron loss

c)

Chronic blood loss

d)

RBC membrane defect

7.

Sickle cell disease is caused by a mutation in the gene coding for:

a)

Alpha-globin

b)

Beta-globin

c)

Gamma-globin

d)

Delta-globin

8.

Plasma cells develop from which cell line?

a)

Myeloid

b)

Lymphoid (B-cell)

c)

Monocytic

d)

Erythroid

9.

A key peripheral smear finding in G6PD deficiency is:

a)

Howell-Jolly bodies

b)

Heinz bodies

c)

Basophilic stippling

d)

Target cells

10.

Aplastic anemia is typically associated with which bone marrow finding?

a)

Hypercellular marrow

b)

Hypocellular marrow

c)

Sideroblasts

d)

Increased blasts

11.

Classification of anemia by MCV:

a)

Microcytic 100 fL

b)

Microcytic 90 fL

c)

Microcytic 95 fL

d)

Microcytic 85 fL

12.

The principle of ESR (erythrocyte sedimentation rate) is:

a)

Measures RBC fragility

b)

Measures rate of RBC settling in plasma

c)

Measures osmotic pressure

d)

Measures clotting time

13.

Basophilic stippling is seen in:

a)

Lead poisoning

b)

Sickle cell anemia

c)

Pernicious anemia

d)

Hereditary spherocytosis

14.

Malaria parasites are found in which cells?

a)

Lymphocytes

b)

RBCs

c)

Neutrophils

d)

Platelets

15.

Schistocytes are characteristic of:

a)

DIC

b)

IDA

c)

Megaloblastic anemia

d)

Thalassemia

16.

Spherocytes are most commonly associated with:

a)

Hereditary spherocytosis

b)

Sickle cell

c)

IDA

d)

Megaloblastic anemia

17.

Elliptocytes are commonly seen in:

a)

Iron deficiency anemia

b)

Hereditary elliptocytosis

c)

Sickle cell

d)

Malaria

18.

A patient has Hb 6.0 g/dL, Hct 18%, MCV 110 fL, hypersegmented neutrophils. The most likely cause is:

a)

Iron deficiency anemia

b)

Folate or B12 deficiency

c)

Aplastic anemia

d)

G6PD deficiency

19.

Which anemia is associated with defective DNA synthesis?

a)

Megaloblastic anemia

b)

Iron deficiency anemia

c)

Thalassemia

d)

Sideroblastic anemia

20.

Target cells are commonly seen in:

a)

Thalassemia

b)

IDA

c)

Megaloblastic anemia

d)

G6PD deficiency

21.

In B12 deficiency anemia, serum methylmalonic acid is:

a)

Increased

b)

Decreased

c)

Normal

d)

Variable

22.

Heinz bodies require which stain for visualization?

a)

Wright

b)

New methylene blue

c)

Giemsa

d)

Gram

23.

A ‘dry tap’ on bone marrow aspiration is most often associated with:

a)

Myelofibrosis

b)

Aplastic anemia

c)

Acute leukemia

d)

Iron deficiency anemia

24.

Rouleaux formation is commonly seen in:

a)

Multiple myeloma

b)

Sickle cell anemia

c)

IDA

d)

Hemolytic anemia

25.

Which anemia results from defective heme synthesis?

a)

Sideroblastic anemia

b)

Thalassemia

c)

IDA

d)

Megaloblastic anemia

26.

What is the most common enzyme deficiency worldwide causing hemolytic anemia?

a)

G6PD deficiency

b)

Pyruvate kinase deficiency

c)

Glutathione reductase deficiency

d)

Hexokinase deficiency

27.

A reticulocyte count is used to assess:

a)

Iron stores

b)

Bone marrow response to anemia

c)

RBC morphology

d)

ESR

28.

Howell-Jolly bodies are composed of:

a)

DNA remnants

b)

RNA remnants

c)

Iron granules

d)

Mitochondria

29.

In sickle cell disease, what lab finding is most likely?

a)

Increased HbA2

b)

Presence of HbS

c)

Increased HbF

d)

Absence of HbA

30.

Bite cells are most associated with:

a)

G6PD deficiency

b)

Sickle cell anemia

c)

Megaloblastic anemia

d)

IDA

31.

Which RBC index reflects average RBC volume?

a)

MCH

b)

MCV

c)

MCHC

d)

RDW

32.

Which of the following will increase ESR?

a)

Polycythemia

b)

Sickle cells

c)

Inflammation

d)

Microcytosis

33.

Anisocytosis refers to:

a)

Variation in size of RBCs

b)

Variation in shape of RBCs

c)

Presence of immature RBCs

d)

Fragmented RBCs

34.

Poikilocytosis refers to:

a)

Variation in size of RBCs

b)

Variation in shape of RBCs

c)

RBC clumping

d)

Immature RBCs

35.

The earliest red cell precursor in bone marrow is:

a)

Pronormoblast

b)

Basophilic normoblast

c)

Polychromatophilic normoblast

d)

Orthochromic normoblast

36.

Which anemia is normocytic, normochromic with a low reticulocyte count?

a)

Aplastic anemia

b)

Iron deficiency anemia

c)

Thalassemia

d)

Sideroblastic anemia

37.

Basophilic stippling in RBCs is due to:

a)

Aggregated ribosomes

b)

DNA fragments

c)

Iron deposits

d)

Mitochondria

38.

Which hemoglobin variant is protective against malaria?

a)

HbS trait

b)

HbC trait

c)

HbE trait

d)

All of the above

39.

Which stain is used to identify malaria parasites?

a)

Wright-Giemsa

b)

Gram

c)

PAS

d)

Sudan black B

40.

Macrocytosis is defined as:

a)

MCV >100 fL

b)

MCV >90 fL

c)

MCV >95 fL

d)

MCV >110 fL

41.

Which anemia has normal serum iron but low serum ferritin?

a)

IDA

b)

Anemia of chronic disease

c)

Thalassemia minor

d)

Sideroblastic anemia

42.

The storage form of iron is primarily:

a)

Ferritin

b)

Hemosiderin

c)

Transferrin

d)

Hemoglobin

43.

Which anemia presents with pancytopenia and hypocellular marrow?

a)

Aplastic anemia

b)

IDA

c)

Thalassemia major

d)

Megaloblastic anemia

44.

Ringed sideroblasts are seen in:

a)

Sideroblastic anemia

b)

Thalassemia

c)

IDA

d)

Megaloblastic anemia

45.

In hereditary spherocytosis, the defect is in:

a)

Spectrin or ankyrin

b)

Globin chain synthesis

c)

Heme synthesis

d)

DNA synthesis

46.

Which anemia is caused by lead poisoning?

a)

Sideroblastic anemia

b)

Thalassemia

c)

IDA

d)

Megaloblastic anemia

47.

A patient with chronic kidney disease is most likely to have anemia due to:

a)

Low erythropoietin

b)

Low folate

c)

Low iron

d)

Bone marrow failure

48.

A patient with Hb 7.2 g/dL, MCV 65 fL, ferritin 5 ng/mL likely has:

a)

IDA

b)

Thalassemia minor

c)

Sideroblastic anemia

d)

Megaloblastic anemia

49.

Which anemia is associated with neurologic symptoms?

a)

B12 deficiency anemia

b)

Folate deficiency anemia

c)

IDA

d)

Sideroblastic anemia

50.

The best screening test for sickle cell disease is:

a)

Hemoglobin electrophoresis

b)

Osmotic fragility

c)

ESR

d)

Coombs test

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