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WorksheetsBLOK 9 2018
Total questions: 113
Worksheet time: 59mins
What is the condition of blood pressure 140/90?
Hypertension grade 1
Hypertension grade 2
Hypertension grade 3
Systolic isolation
Diastolic isolation
Molecular carcinogenesis is influenced by various molecular components. Which of the following molecular components works analogously to a brake?
Oncogene
Proto-oncogene
Mutated tumor suppressor gene
Normal tumor suppressor gene
Down regulation of proto-oncogene
The complementary DNA of 5'-TACGATCATAT-3' is
3'-ATGCTAGTATA-5'
...
...
...
...
What plays an important role in distributing blood throughout the body?
Aorta
Arteries
Arterioles
Capillaries
Veins
Which drug is a substrate for the enzyme CYP2C19?
Imipramine
Desimipramine
Haloperidol
Omeprazole
Amitriptyline
To determine the maturation of B cell differentiation, what indicator is examined?
Ig G
Ig A
Ig D
Ig E
Ig M
A case of a woman with fever for 6 weeks, joint pain, and pale conjunctiva, splenomegaly.
Examination with ANA and GCP(?)
Examination for respiratory infection
Urinary tract infection
Infection present
Anamnesis balalla
There is a polymorphism in the beta 1 adrenergic. But the polymorphism is only on 1 allele DNA. What is the result in electrophoresis?
1 band visible
2 bands visible
3 bands visible (previous answer)
4 bands visible
No bands visible
In the case of Mr. Harun, it is known that at base 636 there is a substitution polymorphism of alanine (A) to guanine (G) with the DNA sequence GACTTGTTTTCAATTGCGCTTAATT. To determine the presence of polymorphism using the RFLP method, which restriction enzyme can recognize the polymorphism?
A1uI (5'-AGCT-3')
EcoRI (5'-GTTTTC-3')
bamHI (5'-CATTCA-3')
smaI (5'-TTAATT-3')
haeIII (5'-CAATTG-3)
What stressor causes death?
Hypovolemic
Hypoxia
Hypotensive
Hypo-systemic
Hypogastric
Mr. Harun, 50 years old, experienced an acute myocardial infarction despite having received clopidogrel to prevent thrombus formation. Upon examination, the serum level of clopidogrel was found to be lower. To determine the presence of polymorphism, what examination should be performed?
PCR and RFLP
PCR and ELISA
PCR and IHK
PCR and Spectrophotometry
PCR and HPLC
The sensory system that functions to generate energy from the environment and within the body is
Limbic system
Afferent
Efferent
...
...
Gestational age is 37 weeks with a weight of 1700. The baby is diagnosed as
Baby full term according to gestation
Baby full term small for gestation
Baby preterm according to gestation
Baby preterm small for gestation
...
A baby diagnosed with a gestational age of 39 weeks and a weight of 2100 grams.
Baby is full term according to gestational age
Baby is full term but small for gestational age
Baby is preterm according to gestational age
Baby is preterm and small for gestational age
Baby is post-term according to gestational age
A patient with hypertension receiving metoprolol shows no significant decrease in blood pressure despite following the medication regimen. What amino acid variant is present in the patient at codon 389 that contributes to this phenomenon?
Glycine
Alanine
Tryptophan
Arginine
Serine
A patient is unable to maintain electrolyte transport in and out of cells, has thick mucus secretion, lung infections, and obstruction, and has salty skin. The delta F508 mutation in the CFTR gene occurs during which process?
Post translation: protein folding
Transcription: polyadenylation signal
Post transcription: glycosylation
Post translation: protein targeting
Translation: polypeptide chain
A 17-year-old woman presents to the clinic with a complaint of three swollen lymph nodes in the neck that appeared three months ago. What is the name of the area?
Submental
Preauricular
Supraclavicular
Sternocleidomastoid
Infraclavicular
Which organ system regulates body fluids?
Neuronal
Urinary
Integumentary
Hormonal
Cardiovascular
What is the inspection point for the ictus cordis?
ICS 5 medial to the left midclavicular line
ICS 5 lateral to the left midclavicular line
ICS 4 medial to the left midclavicular line
ICS 4 lateral to the left midclavicular line
Mr. Name, aged 50, has had his arm amputated. His weight is 50 kg. The distance between the tips of his middle fingers is 124 cm. The distance between the middle and ring fingers on both sides is 120 cm. What was Mr. Name's weight before the amputation?
77
79
81
83
82
Mr. Name, aged 50, has had his arm amputated. His weight is 50 kg. The distance between the tips of his middle fingers is 124 cm. The distance between the middle and ring fingers on both sides is 120 cm. What was Mr. Name's height before the amputation?
142
143
144
146
148
A 45-year-old man has a fever. Other complaints include chills and sweating, as well as nausea and vomiting. Today he has a cough and runny nose. What is the multisystem problem?
Nausea
Vomiting
Chills
Runny nose
Fever
In physiological conditions, which organ is consistently filled with blood (receives a consistent blood supply)?
Neuronal
Respiratory
Digestive
Urinary
Cardiovascular
In physiological conditions, which organ is consistently filled with blood?
neuronal
respiratory
digestive
urinary
cardiovascular
What causes visceral organ pain?
Hypoxia
mechanical trauma
temperature
...
...
What organ system is disturbed if the sclera is icteric (yellow)?
Sensory
Digestive
Nervous
Integumentary
Cardiovascular
Which gene therapy technique can be used in vivo?
Gold bullet
Liposomes
Using viruses as carriers
Using human artificial chromosomes
Transposons
Which risk factor is the highest for carcinogenesis?
Infection
Alcohol
Tobacco
Obesity
Physical inactivity
Examination using a sharp edge...
Babinski
Oppenheim
...
...
no answer
There is a question about weight... Height 165cm weight 80kg. What is the BMI category?
Normal
Overweight
Underweight
Obesity
...
Fever rises continuously without fluctuating more than 1°C.
remittent
continuous
heptic
septic
intermittent
Organ abnormalities in the lower left quadrant...
Left lobe of the liver
Stomach
Ascending colon
Descending colon
Transverse colon
Miss A, age so and so, has complaints of palpitations, wet hands... physical examination shows enlarged eyes, upper eyelid does not close so the sclera is fully visible...
Stellwag's sign
sign
von Graefe's sign
de Musset's sign
...
Various organs become organ systems based on?
Shape
Cell color
Cell quantity
Functional purpose
Tissue attachment
Rhonchi sound...
... prolonged expiration
...
like a half-closed mouth
...
...
A baby girl is born at 37 weeks gestation from a primigravida mother. The mother has had hypertension since 26 weeks of gestation. There is no history of ruptured membranes. The baby is born via C-section with an indication of PEB, and does not cry immediately. Upon physical examination, the birth weight is 1700 grams, length 49 cm, and head circumference 34 cm. What is the diagnosis based on the baby's birth weight?
Normal birth weight
Low birth weight
Very low birth weight
Extremely low birth weight
Large baby
A man suffers from a cough with phlegm for 2 months. Then he complains of coughing up blood for the last 5 days accompanied by fever. One year ago he had...
A man has been suffering from a cough with phlegm for the past 2 months. He then complains of coughing up blood for the past 5 days accompanied by fever. One year ago, he took TB medication for 1 month but did not continue because the symptoms had disappeared. Based on the scenario, what is the main complaint of the man?
Suffering from TB for 1 year after stopping OAT
Coughing up blood for the past 5 days accompanied by fever
Coughing with phlegm for the past 2 months
...
...
A baby boy was born with a weight of 2800 grams, a respiratory rate of 70 breaths per minute, mild intercostal retraction, cyanosis that disappears with O2, slight decrease in air entry, and no grunting. What is the Downes score of the baby?
2
3
4
5
6
What is the function of precipitation in inhibiting the movement of viruses and microorganisms? Precipitation is insoluble?
Opsonization
...
...
...
...
The type of breathing that is fast and deep followed by slow and shallow breathing with periods of apnea for a few moments is called what?
Cheyne-Stokes
Kussmaul
Biot
Normal
Bronchial
The gene that encodes alpha-ketoglutarate dehydrogenase. If polymorphism occurs in that gene, what happens?
Fat accumulation
Increased homocysteine
Methionine accumulation
Decreased homocysteine
...
If there is an accumulation of air in the pleural cavity, what will the percussion sound be?
Hyperresonant
Resonant
Dull
Tympanic
Normal
If there is a mass in the lung, what will the percussion sound be?
Resonant
Hyperresonant
Tympanic
Dull
Normal
If there is blood in the pleural cavity, what will the percussion sound be?
Resonant
Hyperresonant
Tympanic
Dull
Normal
Antibodies can bind to antigens through contact between paratopes and epitopes. For the production of monoclonal antibodies, what is the best type of antigen?
Unideterminant and univalent
Unideterminant and multivalent
Polydeterminant and multivalent
Multideterminant and multivalent
Multideterminant and univalent
What is meant by negative ictus cordis?
Systolic retraction inward and diastolic retraction outward
Systolic retraction outward and diastolic retraction inward
Inspiration retraction inward and expiration retraction outward
Expiration retraction outward and expiration retraction inward
Inspiration and expiration retraction inward
What is the appropriate examination for the disease?
Shifting dullness
Ballotement
Murphy sign
Lasiq sign
...
What examination was performed?
Undulation
Shifting dullness
Murphy
Cullens
Down
Monoclonal antibodies are antibodies obtained by what method?
Fusing immune cells with cancer cells
Dissolving immune cells with cancer cells
Crossbreeding immune cells with cancer cells
Combining immune cells with cancer cells
...
Position of the bone laterally:
Thoracic scoliosis
Lordosis
Kyphosis
Lumbar scoliosis
...
What does the doctor assess during thorax inspection to evaluate dynamic conditions?
Location of the cardiac impulse
Respiratory rate
Venectasia
Shape of the thorax
Which type of malignant tumor is currently the number one killer in both men and women?
Lung
Intestine
Skin
Liver
Prostate
What should be examined if the doctor suspects a genetic polymorphism in a patient who had an acute myocardial infarction despite taking clopidogrel?
CYP2C9
CYP2C19
CYP2E1
CYP2D6
CYP2A6
Which stage of gene therapy involves PCR and RFLP techniques?
Making copies of the normal gene
Identifying the gene causing the disorder
Inserting the vector into the target cell
Inserting the gene copy into the vector
Activating the gene for transcription and translation
What happens when rifampicin is given together with phenytoin, which is a CYP2C12 substrate?
Phenytoin metabolism slows down
Phenytoin metabolism speeds up
Rifampicin metabolism slows down
Rifampicin metabolism speeds up
No metabolism of both drugs occurs
What is the characteristic of the variable region of antibodies?
Has 2 light chain fragments with a molecular weight of 25,000 daltons
Has 2 heavy chain fragments with a molecular weight of 50,000-70,000 daltons
Has 2 types of fragments, kappa and lambda
Functions as a crystallizable fragment
Can recognize various types of antigens
Which mechanism of the hallmark of cancer can be treated with VEGF inhibitors?
Resisting cell death
Inducing angiogenesis
Evading growth suppressors
Avoiding immune destruction
Sustaining proliferative signaling
What does the image show?
Facies leonina
Myxedema
Nephrotic syndrome
Malar rash
Scleroderma
What amino acid replaces glycine in k-ras colon carcinoma?
(a)
What does the image show?
Facies leonina
Myxedema
Nephrotic syndrome
Malar rash
Scleroderma
What is the amino acid substitute for glycine in k-ras colon carcinoma?
Valine
Arginine
Cysteine
Lysine
Serine
When talking about monoclonal antibodies, what is the correct classification?
Based on specificity
Based on chemical properties
Based on T cell dependence
Based on epitopes
Based on paratopes
What virus causes cervical cancer?
Hepatitis B virus
Hepatitis C virus
Epstein-Barr virus
Human papillomavirus
HTLV-1
If the mother of the child forgets the last menstrual period, what can be used?
New Ballard score
APGAR score
Ross score
DNA transfontanela
Ultrasound
What are the characteristics of a premature baby?
Palmar creases less than 1/3
Plantar creases less than 1/3
Thin lanugo
Size of mammary papilla 5-10 mm
...
What is the advantage of polyclonal antibodies?
Requires few test animals
Can be produced in large quantities
Very specific
Meets diagnostic needs
...
What is the hybridoma technique?
Combining immune cells and cancer cells
Dissolving immune cells and cancer cells
Mating immune cells and cancer cells
Splitting immune cells and cancer cells
–
What is the term for eyelids that cannot close completely, with narrowed palpebral fissure?
Strabismus
Lagophthalmos
Myasthenia gravis
Ptosis
Palpebral edema
What is the rapidly enlarging lymph node associated with Burkitt Lymphoma?
MYC translocation
p53 overexpression
BRCA-1 gene mutation
RAS overexpression
SIS translocation
What is the diagnosis for a 47-year-old male who fell and has decreased consciousness?
Alloanamnesis and physical examination
Autoanamnesis and supporting examination
Autoanamnesis, alloanamnesis, and physical examination
Autoanamnesis, family history, and supporting examination
Autoanamnesis, alloanamnesis, physical examination, and supporting examination
In ovarian cancer inherited by daughters, which gene mutation occurs?
MYC
APC
BRCA1 and BRCA2
K-Ras
p53
From the photo below, what can you identify as one characteristic of Fragile X Syndrome?
Large protruding ears
Slanted eyes
Sparse/thin eyebrows
Large front teeth
Rounded chin
What component is needed but not stored long in body cells?
Oxygen
H2O
Carbohydrates
Fats
Proteins
What is the positive sign of examination for pain in the right ICS VI?
Psoas
Ludwig
Murphy
Rovsing
...
ersimpan lama di dalam sel tubuh adalah.....
oksigen
H2O
karbohidrat
lemak
protein
Nyeri tekan di ICS VI kanan, tanda positif pemeriksaan......
psoas
ludwig
murphy
rovsing
hipocrates
Terdapat bercak hitam di perut pada bagian umbilikus dan sekitar...
puddle sign
cullen sign
grey turner
murphy sign
chevoteck sign
Organ dikategorikan dalam satu sistem berdasarkan...
regio anatomi
posisi anatomi
tujuan fungsi
jenis sel
sifat jaringan
Elektroforesis polimorfisme menggunakan pita dna berjumlah...
Gambaran 1 pita dna
2 pita dna
3 pita dna
4 pita dna
Tidak ada pita dna
Sekuen dna pendek dan berulang (10x)
PCR
VNTR
RFLP
Akson
Intron
(rflp) Diketahui dna Tn. A dan Tn. B, setelah diberi enzim restriksi; DNA Tn. A jadi 3 pita sedangkan DNA Tn. B 1 pita (tidak terpotong) ....
enzim retriksi mengenali 2 titik di DNA Tn. A
enzim restriksi mengenali 3 titik di DNA Tn. A
enzim restriksi mengenali 2 titik di DNA Tn. B
....
....
Dokter yg memeriksa mendiagnosis pasien sebagai edema paru. bagaimana gejala batuk yg terjadi pada kasus tersebut?
batuk disertai frothy pink tinged sputum
batuk kering
batuk berdahak
batuk kering lalu berdahak
....
Tubuh mengatur homeostasis (kadar gula) dengan cara...
negative feedback
positive feedback
stimulasi
....
....
Laki-laki achondroplasia, jika punya anak, kemungkinan berapa persen anaknya sakit
25%
50%
75%
0
100%
Trauma pada vaskular akan menyebabkan perubahan pada?
afterload
preload
diameter vaskuler
kontraktilitas
....
Keluhan yang hubungannya dengan multisistem adalah..
demam
batuk
pilek
diare
pusing
Organ sensoris yang berperan dalam mengenal lingkungan luar dan dalam adalah
reseptor
afferen
efferent
sistem limbik
nukleus neural
Mekanisme mana dari Hallmark of Cancer yang dapat diterapi dengan EFGR inhibitor?
Resisting Cell Death
Inducing Angiogenesis
Evading Growth Supressors
Avoiding Immune Destruction
Sustaining Proliferative Signaling
Apabila terjadi inhibisi aktivasi IRFs, proses di bawah ini yang terganggu bahkan tidak terjadi....
Transduksi sinyal
Sintesa rRNA
Sintesa tRNA
Sintesa mRNA
Transformasi
Mutasi delesi gen CFTR yang berisi kode untuk membran glikoprotein menghasilkan protein yang tidak mengalami glikosilasi pada Cystic Fibrosis. Protein tidak dapat melipat dengan benar dan itu tidak terekspresi pada permukaan. Pasien tidak mampu mempertahankan elektrolit transportasi masuk dan keluar dari sel. Sekresi lendir tebal, infeksi paru dan obstruksi, " Salty Skin". Kelainan ini terjadi selama proses
Post translation : protein folding
Transcription : poly adenylation signal
Post translation : glycosylation
Post translation : protein targeting
Translation : polypeptida chain
Poly (A) tail diketahui merupakan salah satu proses
Menghasilkan mRNA matur
Inisiasi translasi
What is the result of the Poly (A) tail process?
Produces mature mRNA
Initiates translation
Located at the 5' mRNA
Makes mRNA unstable
Processed in the cytoplasm
How will the electrophoresis look if both alleles at nucleotide position 641 experience polymorphism?
324 bp
324 bp, 210 bp and 114 bp
210 bp and 114 bp
324 bp and 210 bp
641 bp, 210 bp
What test is it?
Shifting dullness
Rovsing sign
Rebound tenderness
Obturator sign
Costovertebral tenderness
What can be found from genetic examination related to inflammation triggers in the body?
Expression of inflammatory genes increases in the MUFA group
Expression of inflammatory genes increases in the SFA group
Expression of anti-inflammatory genes increases in the SFA group
Expression of anti-inflammatory genes decreases in the MUFA group
Expression of anti-inflammatory genes decreases in the SFA group
Where is the left border of the heart located?
ICS 5 midclavicular line left
ICS 4 midclavicular line left
ICS 6 parasternal line left
ICS 4 parasternal line left
ICS 5 parasternal line left
What is the name of the additional breath sound that is interrupted due to narrowing of the airway?
Dry rhonchi
Wet rhonchi
Wheezing
Vesicular
Stridor
What is the cause of the high fever in a 2-year-old girl who has been admitted to the ER?
Endogenous IL-1
Endogenous IL-2
Exogenous IL-0
Exogenous IFN Alpha
Exogenous lipopolysaccharide
Which organ system directly maintains the body's fluid balance?
Neuronal
Cardiovascular
Urinary
Hormonal
Integument
What about the FTO gene?
Related to body fat mass
Individuals with heterozygous alleles gain weight more easily
Individuals with homozygous AA alleles have no appetite
Encodes an abnormal protein
Increases skeletal muscle mass
When does bowel sound decrease?
Peritonitis
Obstructive ileus
Paralytic ileus
Necrolithiasis
What is the condition when the intestines are noisy?
Peritonitis
Ileus obstruction
Ileus paralytic
Necrolitis enteroticans
Post-operative
If Rifampicin is given together with Phenytoin, which is a substrate of CYP2C12, then....
The metabolism of Phenytoin will slow down
The metabolism of Phenytoin will speed up
The metabolism of Rifampicin will slow down
The metabolism of Rifampicin will speed up
The metabolism of both drugs will not occur
A mutation occurs at the Normal Cleavage Site Factor of blood coagulation and causes excessive production of that coagulation factor. This leads to Hypercoagulability. Increased risk of DVT, PE. Pathological: The consequences of this Thrombophilia disease are caused by defects in transcription at the time of...
Immature mRNA synthesis
Intron splicing
Alternative splicing
Poly(A) adenylation signal
5' mRNA cap
What is the correct diagnosis according to the image?
Becker muscular dystrophy
Duchenne muscular dystrophy
Fragile X syndrome
Huntington disease
Neurofibromatosis type 1
Nn. B came to the doctor complaining that for the past three years he has experienced....., three months ago he often coughed and sweated at night, and one week ago he experienced.... The history of the disease started from...
3 years ago experienced..., 3 months ago experienced..., one week ago experienced....
one week ago experienced...., 3 months ago experienced..., 3 years ago experienced...
...
...
...
What examination is shown in the image below?
Bimanual
...
Shifting dullness
Rovsing sign
Undulation
At what Korotkoff sound does diastolic appear?
I
II
III
IV
V
A physical examination of a child shows body disproportion with a relatively larger head. The suspected diagnosis for this child is...
Achondroplasia
Duchenne Muscular Dystrophy
Macrocephaly -> hydrocephalus
...
...
Polymorphism in CYP2E19 will provide an enhanced metabolizer effect on the patient. Rifampicin when given together with phenytoin will cause...
Phenytoin metabolism to be inhibited
Phenytoin metabolism to be accelerated
Rifampicin metabolism to be slowed down
Rifampicin metabolism to be accelerated
No metabolism of both drugs occurs
A stop codon causes the ribosome to stop during the translation process. This results in...
No polypeptide/amino acid formation
Shortening of the polypeptide chain
Lengthening of the polypeptide chain
The translation process is unaffected and continues
What replaces glycine in H ras/K ras (I forgot the main point between these two)...
Valine
Alanine
Methionine
Arginine
