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Veterinary General Pathology: The Animal cell and its organelles

Total questions: 30

Worksheet time: 15mins

Name
Class
Date
1.

Which organelle’s dysfunction would most likely impair both detoxification and lipid metabolism in hepatocytes?

a)

Golgi apparatus

b)

Smooth ER

c)

Peroxisome

d)

Lysosome

2.

Which of the following best explains why mature erythrocytes are unable to repair themselves?

a)

Lack of mitochondria

b)

Absence of nucleus and organelles

c)

Thin cell membrane

d)

High hemoglobin content

3.

In a biopsy, the Golgi apparatus appears swollen and disorganized. Which cellular function is most likely compromised?

a)

DNA replication

b)

Protein packaging and secretion

c)

Lipid digestion

d)

ATP synthesis

4.

Which organelle would be most affected in a disease involving defective protein folding and accumulation of misfolded proteins?

a)

Smooth ER

b)

Rough ER

c)

Golgi apparatus

d)

Ribosomes

5.

A cell shows detachment of ribosomes from the ER and reduced protein synthesis. Which function is most directly impaired?

a)

Lipid metabolism

b)

Cell repair and regeneration

c)

DNA transcription

d)

Intracellular transport

6.

Which organelle’s dysfunction is most likely to impair intracellular transport and organelle positioning?

a)

Cytoskeleton

b)

Ribosomes

c)

Nucleolus

d)

Vesicles

7.

Which organelle is most directly involved in the synthesis of polypeptides from mRNA?

a)

Golgi apparatus

b)

Ribosomes

c)

Nucleolus

d)

Smooth ER

8.

Which organelle is most prominent in cells actively synthesizing proteins?

a)

Nucleolus

b)

Peroxisome

c)

Smooth ER

d)

Centriole

9.

Which of the following best explains why ciliary dysfunction leads to respiratory infections?

a)

Reduced ATP production

b)

Impaired mucus clearance

c)

Increased cell division

d)

Enhanced protein synthesis

10.

Which organelle is involved in organizing spindle fibers during mitosis?

a)

Centrioles

b)

Golgi apparatus

c)

Cytoskeleton

d)

Ribosomes

11.

Which organelle’s failure would most directly impair secretion of hormones or enzymes?

a)

Golgi apparatus

b)

Ribosomes

c)

Peroxisomes

d)

Nucleolus

12.

Which of the following best describes the role of the cytoplasm in cell pathology?

a)

DNA replication

b)

Metabolic reactions and organelle support

c)

Protein packaging

d)

Cell division

13.

Which organelle’s dysfunction would most likely impair both intracellular transport and cell shape maintenance?

a)

Golgi apparatus

b)

Cytoskeleton

c)

Smooth ER

d)

Vesicles

14.

A veterinary histologist notes pale, vacuolated mitochondria in renal tissue. What is the most likely implication?

a)

Enhanced respiration

b)

Metabolic failure

c)

Protein accumulation

d)

Lipid synthesis

15.

Which organelle is most vulnerable to rupture during necrosis, leading to enzymatic self-digestion of the cell?

a)

Ribosomes

b)

Lysosomes

c)

Peroxisomes

d)

Golgi apparatus

16.

In a cell with impaired protein secretion and swollen cisternae, which organelle is most likely affected?

a)

Rough ER

b)

Golgi apparatus

c)

Nucleolus

d)

Smooth ER

17.

Which organelle’s failure would most directly impair the breakdown of long-chain fatty acids and detoxification of reactive oxygen species?

a)

Mitochondria

b)

Peroxisomes

c)

Lysosomes

d)

Ribosomes

18.

Which of the following best explains why animal cells can adopt diverse shapes unlike plant cells?

a)

Presence of mitochondria

b)

Lack of rigid cell wall

c)

Presence of centrioles

d)

Semipermeable membrane

19.

A cell shows reduced ribosomal density and impaired protein synthesis. What downstream effect is most likely?

a)

Enhanced lipid metabolism

b)

Impaired cell repair

c)

Increased mitosis

d)

Improved detoxification

20.

Which organelle’s dysfunction is most likely to result in accumulation of undigested substrates visible as vacuoles?

a)

Golgi apparatus

b)

Lysosomes

c)

Ribosomes

d)

Peroxisomes

21.

A sperm cell shows impaired motility due to structural defects. Which organelle is most likely affected?

a)

Cilia

b)

Flagella

c)

Centrioles

d)

Cytoskeleton

22.

A veterinary pathologist observes a cell with intact organelles but a fragmented nucleus. Which nuclear change is most likely present?

a)

Pyknosis

b)

Karyorrhexis

c)

Karyolysis

d)

Apoptosis

23.

Which organelle’s dysfunction would most likely impair both protein synthesis and intracellular transport simultaneously?

a)

Ribosomes

b)

Rough ER

c)

Golgi apparatus

d)

Cytoskeleton

24.

A cell shows loss of nuclear envelope integrity and uncontrolled exchange between nucleus and cytoplasm. What is the most likely consequence?

a)

Enhanced gene expression

b)

Disrupted nuclear stability

c)

Increased protein synthesis

d)

Improved RNA transport

25.

A cell displays excessive lipid droplets and vacuoles in the cytoplasm. Which organelle is most likely dysfunctional?

a)

Smooth ER

b)

Golgi apparatus

c)

Peroxisomes

d)

Lysosomes

26.

A cell shows reduced nucleolar size and irregular shape. What cellular activity is most likely compromised?

a)

DNA replication

b)

Ribosomal RNA synthesis

c)

Lipid metabolism

d)

Protein packaging

27.

Which organelle’s dysfunction would most likely result in accumulation of misfolded proteins and activation of stress responses?

a)

Smooth ER

b)

Rough ER

c)

Golgi apparatus

d)

Ribosomes

28.

A cell undergoing necrosis shows cytoplasmic granularity and loss of staining. What does this most likely indicate?

a)

Enhanced metabolism

b)

Enzyme leakage and degeneration

c)

Protein synthesis

d)

DNA fragmentation

29.

Which organelle’s disruption would most directly impair the directional movement of mucus in respiratory epithelium?

a)

Flagella

b)

Cilia

c)

Cytoskeleton

d)

Vesicles

30.

Which organelle is most directly involved in packaging enzymes for lysosomes?

a)

Ribosomes

b)

Golgi apparatus

c)

Smooth ER

d)

Peroxisomes