WorksheetsBone Development
Total questions: 80
Worksheet time: 40mins
What is osteogenesis (a.k.a. ossification)?
The process of bone tissue formation
The process of muscle growth
The process of blood cell formation
The process of nerve development
In embryos, osteogenesis leads to the formation of the _________
bony skeleton
cartilaginous skeleton
muscular tissue
nervous tissue
In children and young adults, ossification occurs as part of _________
bone growth
digestion
respiration
circulation
In adults, ossification occurs as part of bone remodeling and _________
bone repair
muscle contraction
nerve transmission
blood filtration
Refer to the diagram of the developing embryo. Which type of bone formation is labeled near the head region?
A) Endochondral bones forming
B) Intramembranous bones forming
C) Cartilaginous bones forming
D) None of the above
Refer to the diagram of the developing embryo. Fill in the blank: The bones forming in the limb region are called _________.
Endochondral bones forming
Dermal bones forming
Cartilaginous bones forming
Membranous bones forming
What is intramembranous ossification?
The replacement of cartilage with bony tissue
The replacement of sheet-like connective tissue membranes with bony tissue
The formation of bone from blood cells
The conversion of muscle tissue to bone
Intramembranous ossification exists as ______ prior to ossification.
mesenchyme
cartilage
epithelium
adipose tissue
Which bones are formed by intramembranous ossification?
Femur and tibia
Frontal, parietal, temporal, and occipital bones, facial bones, and clavicles
Vertebrae and ribs
Pelvis and scapula
What is the outermost layer shown in the diagram of intramembranous ossification?
Skin
Periosteum
Compact bone
Bone marrow
Which tissue is located directly beneath the skin in the diagram of intramembranous ossification?
Connective tissue
Cartilage tissue
Muscle tissue
Epithelial tissue
What type of bone is shown in the middle layer of the diagram of intramembranous ossification?
Spongy bone
Compact bone
Cartilage
Fibrous tissue
Which cells are responsible for forming new bone tissue in intramembranous ossification?
Osteoblasts
Chondrocytes
Erythrocytes
Fibroblasts
In the diagram of intramembranous ossification, which structure is labeled as the initial tissue from which bone develops?
Mesenchyme
Cartilage
Periosteum
Compact bone
Which of the following is NOT labeled in the diagram of intramembranous ossification?
A) Osteoid
B) Cartilage
C) Osteocytes
D) Collagen fiber
What is the function of osteocytes as shown in the diagram of intramembranous ossification?
Osteocytes maintain bone tissue.
Osteocytes break down bone tissue.
Osteocytes produce cartilage matrix.
Osteocytes initiate blood cell formation.
What is endochondral ossification?
The replacement of hyaline cartilage with bony tissue
The formation of cartilage from bone
The conversion of mesenchyme to ectoderm
The breakdown of bony tissue into cartilage
Identify the tissue labeled at the top of the diagram.
Cartilage
Mesenchyme
Ectoderm
Bone
Fill in the blank: The middle label in the diagram points to __________.
Mesenchyme
Ectoderm
Endoderm
Neural tube
Fill in the blank: The bottom label in the diagram points to __________.
Ectoderm
Mesoderm
Endoderm
Blastocoel
Which stage in endochondral ossification is represented by the 'Cartilaginous model'?
Cartilaginous model
Calcified cartilage
Developing periosteum
Compact bone developing
Fill in the blank: The ________ is the stage where the cartilage begins to calcify during endochondral ossification.
Calcified cartilage
Resting cartilage
Proliferating cartilage
Articular cartilage
Which part of the bone is formed during the 'Secondary ossification center' stage?
Medullary cavity
Epiphyseal disk
Spongy bone
Compact bone
Fill in the blank: The ________ is the area where blood vessels invade the developing bone during endochondral ossification.
Primary ossification center
Epiphyseal plate
Periosteum
Secondary ossification center
The medullary cavity is formed before the compact bone during endochondral ossification.
True
False
Refer to the diagram. Fill in the blank: The process by which bone grows in length is similar to _____________.
Endochondral Ossification
Intramembranous Ossification
Appositional Growth
Bone Remodeling
Which hormone influences bone growth in length?
Thyroid hormone
Growth hormone from the anterior pituitary gland
Insulin
Melatonin
Sex hormones from the ovaries and testes influence bone growth in length.
True
False
Cartilage and bone interact during the process of bone growth in length by:
Cartilage is replaced by bone at the growth plate, allowing bones to lengthen.
Bone forms directly without any cartilage involvement.
Cartilage remains unchanged and does not contribute to bone growth.
Bone dissolves cartilage, but no new bone is formed.
Fill in the blank: The process by which bones grow in width is called _________.
Appositional growth
Endochondral ossification
Interstitial growth
Epiphyseal closure
Which cells beneath the periosteum secrete bone matrix on the external surface?
A) Osteoclasts
B) Osteoblasts
C) Chondrocytes
D) Fibroblasts
Fill in the blank: Osteoclasts on the endosteal surface of the diaphysis ________ bone.
remove
deposit
strengthen
form
Look at the images under the title 'Abnormalities in Growth'. What do these images illustrate?
Normal growth
Abnormalities in growth
Healthy lifestyle
Sports activities
Based on the images and the title 'Abnormalities in Growth', name one condition that could cause a person to be much taller or much shorter than average.
Gigantism
Diabetes
Asthma
Arthritis
Bone remodeling is essential for _________
homeostasis
digestion
respiration
photosynthesis
Bone architecture is constantly _________
changing
static
shrinking
growing
Bone Homeostasis: What percentage of our bone mass do we recycle each week?
1-2%
3-4%
5-7%
8-10%
Which two processes constitute bone remodeling?
Bone Deposit and Bone Resorption
Bone Growth and Bone Loss
Bone Healing and Bone Fracture
Bone Formation and Bone Decay
Fill in the blank: Remodeling doesn’t happen ________.
uniformly
quickly
randomly
automatically
Bone remodeling is coupled and coordinated by which two types of cells?
Osteoblasts and osteoclasts
Chondrocytes and fibroblasts
Erythrocytes and leukocytes
Adipocytes and macrophages
Bone remodeling is helped by the stress sensing osteocytes.
True
False
What is another term for the coordinated process of bone remodeling involving osteoblasts, osteoclasts, and osteocytes?
Remodeling unit
Osteogenic cycle
Bone fusion
Skeletal ossification
Fill in the blank: The first step in the process of bone remodeling is _________
Origination
Resorption
Ossification
Calcification
Fill in the blank: The recruitment of ________ is a step in the process of bone remodeling.
Osteoclast
Chondrocyte
Fibroblast
Erythrocyte
Fill in the blank: _________ is the process where bone tissue is broken down and absorbed.
Resorption
Ossification
Calcification
Remodeling
Fill in the blank: The recruitment of ________ follows resorption in bone remodeling.
Osteoblast
Chondrocyte
Fibroblast
Adipocyte
Fill in the blank: _________ formation is a step in the process of bone remodeling.
Osteoid
Chondrocyte
Myelin
Keratin
Fill in the blank: _________ is the process where minerals are deposited in the bone matrix during bone remodeling.
Mineralization
Ossification
Resorption
Calcification
Fill in the blank: _________ maturation is a step in the process of bone remodeling.
Mineral
Cellular
Osteoid
Cartilage
Fill in the blank: The final step in the process of bone remodeling is _________.
Quiescence
Resorption
Ossification
Proliferation
Where does bone deposit occur? Fill in the blank: Bone deposit occurs where bone is ______ or where added bone strength is needed.
injured
healthy
dense
old
Optimal bone deposit can only occur with a healthy diet rich in which of the following?
Proteins, vitamin C, vitamin D, vitamin A, and several minerals
Fats and sugars
Carbohydrates and water
Only vitamin D
What is the term for the cells involved in bone deposit? The cells involved in bone deposit are called ______.
Osteocytes
Chondrocytes
Erythrocytes
Leukocytes
According to the information on 'Control of Remodeling', is remodeling a continuous process?
Yes
No
How many control loops regulate remodeling according to the 'Control of Remodeling' information?
Two
One
Three
Four
Which of the following is a control loop that regulates remodeling?
Negative feedback hormone mechanism to control Calcium
Positive feedback hormone mechanism to control Calcium
Response to mechanical stress and gravitational forces
Both A and C
Fill in the blank: Remodeling is regulated by a negative feedback hormone mechanism to control _______.
Calcium
Glucose
Sodium
Potassium
99% of the calcium is present in _________?
bone minerals
blood plasma
muscle fibers
nerve cells
Calcium is responsible for physiological processes such as transmission of nerve impulses, muscle contraction, blood coagulation, secretion by glands and nerve cells, and cell division. Which of the following is NOT a process that calcium is responsible for?
A) Transmission of nerve impulses
B) Muscle contraction
C) Blood coagulation
D) Photosynthesis
Less than _______ is present in the blood.
1.5g
5g
10g
0.5g
Calcium is maintained between _______ per dl of blood.
9-11mg
3-5mg
12-15mg
6-8mg
The daily requirement of calcium is _______ until the age of 10 and _______ from age 11-24.
400-800mg until the age of 10 and 1200-1500mg from age 11-24
800-1000mg until the age of 10 and 1000-1200mg from age 11-24
200-400mg until the age of 10 and 800-1000mg from age 11-24
1000-1200mg until the age of 10 and 1500-2000mg from age 11-24
Hormonal Mechanism: When is Parathyroid Hormone released?
When blood levels of ionic calcium rise
When blood levels of ionic calcium decline
When blood pressure increases
When blood sugar decreases
Hormonal Mechanism: What does an increase in Parathyroid Hormone stimulate?
Osteoblasts to form bone
Osteoclasts to resorb bone
Osteocytes to divide
Chondrocytes to produce cartilage
Hormonal Mechanism: Osteoclasts break down both old and new matrix, but do not touch the osteoid. Why?
Because it contains calcium salts
Because it lacks calcium salts
Because it is too hard
Because it is protected by hormones
Hormonal Mechanism: As calcium levels rise, the stimulus for PTH _______.
ends
increases
remains unchanged
intensifies
Hormonal Mechanism: The decline of PTH reverses its effects and causes blood calcium levels to _______.
decrease
increase
remain the same
fluctuate
Greatest stress, both compression and tension, are on the _______ of bone.
exterior
interior
center
marrow
Internal to the exterior region, tension and compression forces _______ each other out.
cancel
increase
multiply
separate
Because no stress occurs at the bone’s center, the lack of bone tissue in the medullary cavity does not impair the strength of long bones.
True
False
According to Wolff's Law, what happens to a bone in response to the demands placed on it?
It shrinks
It grows or remodels
It dissolves
It becomes brittle
Wolff's Law states that a bone grows or remodels in response to the demands placed on it.
True
False
Fill in the blank: Long bones are _______ midway along the diaphysis according to Wolff's Law.
thickest
thinnest
shortest
weakest
Which bones are thickest where they are most likely to buckle?
Flat bones
Curved bones
Short bones
Irregular bones
Fill in the blank: The trabeculae of spongy bone form trusses or struts along lines of _______.
compression
tension
fracture
growth
Large, boney projections occur where heavy, active muscles attach according to Wolff's Law.
True
False
Refer to the diagram of the femur under the title 'Bone Strength'. What is the function of the area labeled 'Head of femur'?
It bears the body's weight
It is the point of no stress
It is where tension occurs
It is where compression occurs
Refer to the diagram of the femur under the title 'Bone Strength'. The area marked with arrows and labeled 'Tension here' indicates:
Where the bone is compressed
Where the bone is under tension
The head of the femur
The point of no stress
Refer to the diagram of the femur under the title 'Bone Strength'. The 'Point of no stress' is located at the ________ of the femur.
center
top
bottom
side
Refer to the diagram of the femur under the title 'Bone Strength'. True or False: Compression occurs at the same location as tension in the femur.
True
False
