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Bone Development

Total questions: 80

Worksheet time: 40mins

Name
Class
Date
1.

What is osteogenesis (a.k.a. ossification)?

a)

The process of bone tissue formation

b)

The process of muscle growth

c)

The process of blood cell formation

d)

The process of nerve development

2.

In embryos, osteogenesis leads to the formation of the _________

a)

bony skeleton

b)

cartilaginous skeleton

c)

muscular tissue

d)

nervous tissue

3.

In children and young adults, ossification occurs as part of _________

a)

bone growth

b)

digestion

c)

respiration

d)

circulation

4.

In adults, ossification occurs as part of bone remodeling and _________

a)

bone repair

b)

muscle contraction

c)

nerve transmission

d)

blood filtration

5.

Refer to the diagram of the developing embryo. Which type of bone formation is labeled near the head region?

a)

A) Endochondral bones forming

b)

B) Intramembranous bones forming

c)

C) Cartilaginous bones forming

d)

D) None of the above

6.

Refer to the diagram of the developing embryo. Fill in the blank: The bones forming in the limb region are called _________.

a)

Endochondral bones forming

b)

Dermal bones forming

c)

Cartilaginous bones forming

d)

Membranous bones forming

7.

What is intramembranous ossification?

a)

The replacement of cartilage with bony tissue

b)

The replacement of sheet-like connective tissue membranes with bony tissue

c)

The formation of bone from blood cells

d)

The conversion of muscle tissue to bone

8.

Intramembranous ossification exists as ______ prior to ossification.

a)

mesenchyme

b)

cartilage

c)

epithelium

d)

adipose tissue

9.

Which bones are formed by intramembranous ossification?

a)

Femur and tibia

b)

Frontal, parietal, temporal, and occipital bones, facial bones, and clavicles

c)

Vertebrae and ribs

d)

Pelvis and scapula

10.

What is the outermost layer shown in the diagram of intramembranous ossification?

a)

Skin

b)

Periosteum

c)

Compact bone

d)

Bone marrow

11.

Which tissue is located directly beneath the skin in the diagram of intramembranous ossification?

a)

Connective tissue

b)

Cartilage tissue

c)

Muscle tissue

d)

Epithelial tissue

12.

What type of bone is shown in the middle layer of the diagram of intramembranous ossification?

a)

Spongy bone

b)

Compact bone

c)

Cartilage

d)

Fibrous tissue

13.

Which cells are responsible for forming new bone tissue in intramembranous ossification?

a)

Osteoblasts

b)

Chondrocytes

c)

Erythrocytes

d)

Fibroblasts

14.

In the diagram of intramembranous ossification, which structure is labeled as the initial tissue from which bone develops?

a)

Mesenchyme

b)

Cartilage

c)

Periosteum

d)

Compact bone

15.

Which of the following is NOT labeled in the diagram of intramembranous ossification?

a)

A) Osteoid

b)

B) Cartilage

c)

C) Osteocytes

d)

D) Collagen fiber

16.

What is the function of osteocytes as shown in the diagram of intramembranous ossification?

a)

Osteocytes maintain bone tissue.

b)

Osteocytes break down bone tissue.

c)

Osteocytes produce cartilage matrix.

d)

Osteocytes initiate blood cell formation.

17.

What is endochondral ossification?

a)

The replacement of hyaline cartilage with bony tissue

b)

The formation of cartilage from bone

c)

The conversion of mesenchyme to ectoderm

d)

The breakdown of bony tissue into cartilage

18.

Identify the tissue labeled at the top of the diagram.

a)

Cartilage

b)

Mesenchyme

c)

Ectoderm

d)

Bone

19.

Fill in the blank: The middle label in the diagram points to __________.

a)

Mesenchyme

b)

Ectoderm

c)

Endoderm

d)

Neural tube

20.

Fill in the blank: The bottom label in the diagram points to __________.

a)

Ectoderm

b)

Mesoderm

c)

Endoderm

d)

Blastocoel

21.

Which stage in endochondral ossification is represented by the 'Cartilaginous model'?

a)

Cartilaginous model

b)

Calcified cartilage

c)

Developing periosteum

d)

Compact bone developing

22.

Fill in the blank: The ________ is the stage where the cartilage begins to calcify during endochondral ossification.

a)

Calcified cartilage

b)

Resting cartilage

c)

Proliferating cartilage

d)

Articular cartilage

23.

Which part of the bone is formed during the 'Secondary ossification center' stage?

a)

Medullary cavity

b)

Epiphyseal disk

c)

Spongy bone

d)

Compact bone

24.

Fill in the blank: The ________ is the area where blood vessels invade the developing bone during endochondral ossification.

a)

Primary ossification center

b)

Epiphyseal plate

c)

Periosteum

d)

Secondary ossification center

25.

The medullary cavity is formed before the compact bone during endochondral ossification.

a)

True

b)

False

26.

Refer to the diagram. Fill in the blank: The process by which bone grows in length is similar to _____________.

a)

Endochondral Ossification

b)

Intramembranous Ossification

c)

Appositional Growth

d)

Bone Remodeling

27.

Which hormone influences bone growth in length?

a)

Thyroid hormone

b)

Growth hormone from the anterior pituitary gland

c)

Insulin

d)

Melatonin

28.

Sex hormones from the ovaries and testes influence bone growth in length.

a)

True

b)

False

29.

Cartilage and bone interact during the process of bone growth in length by:

a)

Cartilage is replaced by bone at the growth plate, allowing bones to lengthen.

b)

Bone forms directly without any cartilage involvement.

c)

Cartilage remains unchanged and does not contribute to bone growth.

d)

Bone dissolves cartilage, but no new bone is formed.

30.

Fill in the blank: The process by which bones grow in width is called _________.

a)

Appositional growth

b)

Endochondral ossification

c)

Interstitial growth

d)

Epiphyseal closure

31.

Which cells beneath the periosteum secrete bone matrix on the external surface?

a)

A) Osteoclasts

b)

B) Osteoblasts

c)

C) Chondrocytes

d)

D) Fibroblasts

32.

Fill in the blank: Osteoclasts on the endosteal surface of the diaphysis ________ bone.

a)

remove

b)

deposit

c)

strengthen

d)

form

33.

Look at the images under the title 'Abnormalities in Growth'. What do these images illustrate?

a)

Normal growth

b)

Abnormalities in growth

c)

Healthy lifestyle

d)

Sports activities

34.

Based on the images and the title 'Abnormalities in Growth', name one condition that could cause a person to be much taller or much shorter than average.

a)

Gigantism

b)

Diabetes

c)

Asthma

d)

Arthritis

35.

Bone remodeling is essential for _________

a)

homeostasis

b)

digestion

c)

respiration

d)

photosynthesis

36.

Bone architecture is constantly _________

a)

changing

b)

static

c)

shrinking

d)

growing

37.

Bone Homeostasis: What percentage of our bone mass do we recycle each week?

a)

1-2%

b)

3-4%

c)

5-7%

d)

8-10%

38.

Which two processes constitute bone remodeling?

a)

Bone Deposit and Bone Resorption

b)

Bone Growth and Bone Loss

c)

Bone Healing and Bone Fracture

d)

Bone Formation and Bone Decay

39.

Fill in the blank: Remodeling doesn’t happen ________.

a)

uniformly

b)

quickly

c)

randomly

d)

automatically

40.

Bone remodeling is coupled and coordinated by which two types of cells?

a)

Osteoblasts and osteoclasts

b)

Chondrocytes and fibroblasts

c)

Erythrocytes and leukocytes

d)

Adipocytes and macrophages

41.

Bone remodeling is helped by the stress sensing osteocytes.

a)

True

b)

False

42.

What is another term for the coordinated process of bone remodeling involving osteoblasts, osteoclasts, and osteocytes?

a)

Remodeling unit

b)

Osteogenic cycle

c)

Bone fusion

d)

Skeletal ossification

43.

Fill in the blank: The first step in the process of bone remodeling is _________

a)

Origination

b)

Resorption

c)

Ossification

d)

Calcification

44.

Fill in the blank: The recruitment of ________ is a step in the process of bone remodeling.

a)

Osteoclast

b)

Chondrocyte

c)

Fibroblast

d)

Erythrocyte

45.

Fill in the blank: _________ is the process where bone tissue is broken down and absorbed.

a)

Resorption

b)

Ossification

c)

Calcification

d)

Remodeling

46.

Fill in the blank: The recruitment of ________ follows resorption in bone remodeling.

a)

Osteoblast

b)

Chondrocyte

c)

Fibroblast

d)

Adipocyte

47.

Fill in the blank: _________ formation is a step in the process of bone remodeling.

a)

Osteoid

b)

Chondrocyte

c)

Myelin

d)

Keratin

48.

Fill in the blank: _________ is the process where minerals are deposited in the bone matrix during bone remodeling.

a)

Mineralization

b)

Ossification

c)

Resorption

d)

Calcification

49.

Fill in the blank: _________ maturation is a step in the process of bone remodeling.

a)

Mineral

b)

Cellular

c)

Osteoid

d)

Cartilage

50.

Fill in the blank: The final step in the process of bone remodeling is _________.

a)

Quiescence

b)

Resorption

c)

Ossification

d)

Proliferation

51.

Where does bone deposit occur? Fill in the blank: Bone deposit occurs where bone is ______ or where added bone strength is needed.

a)

injured

b)

healthy

c)

dense

d)

old

52.

Optimal bone deposit can only occur with a healthy diet rich in which of the following?

a)

Proteins, vitamin C, vitamin D, vitamin A, and several minerals

b)

Fats and sugars

c)

Carbohydrates and water

d)

Only vitamin D

53.

What is the term for the cells involved in bone deposit? The cells involved in bone deposit are called ______.

a)

Osteocytes

b)

Chondrocytes

c)

Erythrocytes

d)

Leukocytes

54.

According to the information on 'Control of Remodeling', is remodeling a continuous process?

a)

Yes

b)

No

55.

How many control loops regulate remodeling according to the 'Control of Remodeling' information?

a)

Two

b)

One

c)

Three

d)

Four

56.

Which of the following is a control loop that regulates remodeling?

a)

Negative feedback hormone mechanism to control Calcium

b)

Positive feedback hormone mechanism to control Calcium

c)

Response to mechanical stress and gravitational forces

d)

Both A and C

57.

Fill in the blank: Remodeling is regulated by a negative feedback hormone mechanism to control _______.

a)

Calcium

b)

Glucose

c)

Sodium

d)

Potassium

58.

99% of the calcium is present in _________?

a)

bone minerals

b)

blood plasma

c)

muscle fibers

d)

nerve cells

59.

Calcium is responsible for physiological processes such as transmission of nerve impulses, muscle contraction, blood coagulation, secretion by glands and nerve cells, and cell division. Which of the following is NOT a process that calcium is responsible for?

a)

A) Transmission of nerve impulses

b)

B) Muscle contraction

c)

C) Blood coagulation

d)

D) Photosynthesis

60.

Less than _______ is present in the blood.

a)

1.5g

b)

5g

c)

10g

d)

0.5g

61.

Calcium is maintained between _______ per dl of blood.

a)

9-11mg

b)

3-5mg

c)

12-15mg

d)

6-8mg

62.

The daily requirement of calcium is _______ until the age of 10 and _______ from age 11-24.

a)

400-800mg until the age of 10 and 1200-1500mg from age 11-24

b)

800-1000mg until the age of 10 and 1000-1200mg from age 11-24

c)

200-400mg until the age of 10 and 800-1000mg from age 11-24

d)

1000-1200mg until the age of 10 and 1500-2000mg from age 11-24

63.

Hormonal Mechanism: When is Parathyroid Hormone released?

a)

When blood levels of ionic calcium rise

b)

When blood levels of ionic calcium decline

c)

When blood pressure increases

d)

When blood sugar decreases

64.

Hormonal Mechanism: What does an increase in Parathyroid Hormone stimulate?

a)

Osteoblasts to form bone

b)

Osteoclasts to resorb bone

c)

Osteocytes to divide

d)

Chondrocytes to produce cartilage

65.

Hormonal Mechanism: Osteoclasts break down both old and new matrix, but do not touch the osteoid. Why?

a)

Because it contains calcium salts

b)

Because it lacks calcium salts

c)

Because it is too hard

d)

Because it is protected by hormones

66.

Hormonal Mechanism: As calcium levels rise, the stimulus for PTH _______.

a)

ends

b)

increases

c)

remains unchanged

d)

intensifies

67.

Hormonal Mechanism: The decline of PTH reverses its effects and causes blood calcium levels to _______.

a)

decrease

b)

increase

c)

remain the same

d)

fluctuate

68.

Greatest stress, both compression and tension, are on the _______ of bone.

a)

exterior

b)

interior

c)

center

d)

marrow

69.

Internal to the exterior region, tension and compression forces _______ each other out.

a)

cancel

b)

increase

c)

multiply

d)

separate

70.

Because no stress occurs at the bone’s center, the lack of bone tissue in the medullary cavity does not impair the strength of long bones.

a)

True

b)

False

71.

According to Wolff's Law, what happens to a bone in response to the demands placed on it?

a)

It shrinks

b)

It grows or remodels

c)

It dissolves

d)

It becomes brittle

72.

Wolff's Law states that a bone grows or remodels in response to the demands placed on it.

a)

True

b)

False

73.

Fill in the blank: Long bones are _______ midway along the diaphysis according to Wolff's Law.

a)

thickest

b)

thinnest

c)

shortest

d)

weakest

74.

Which bones are thickest where they are most likely to buckle?

a)

Flat bones

b)

Curved bones

c)

Short bones

d)

Irregular bones

75.

Fill in the blank: The trabeculae of spongy bone form trusses or struts along lines of _______.

a)

compression

b)

tension

c)

fracture

d)

growth

76.

Large, boney projections occur where heavy, active muscles attach according to Wolff's Law.

a)

True

b)

False

77.

Refer to the diagram of the femur under the title 'Bone Strength'. What is the function of the area labeled 'Head of femur'?

a)

It bears the body's weight

b)

It is the point of no stress

c)

It is where tension occurs

d)

It is where compression occurs

78.

Refer to the diagram of the femur under the title 'Bone Strength'. The area marked with arrows and labeled 'Tension here' indicates:

a)

Where the bone is compressed

b)

Where the bone is under tension

c)

The head of the femur

d)

The point of no stress

79.

Refer to the diagram of the femur under the title 'Bone Strength'. The 'Point of no stress' is located at the ________ of the femur.

a)

center

b)

top

c)

bottom

d)

side

80.

Refer to the diagram of the femur under the title 'Bone Strength'. True or False: Compression occurs at the same location as tension in the femur.

a)

True

b)

False