WorksheetsGlomerulonephritis tute 2025
Total questions: 13
Worksheet time: 10mins
The characteristic light microscopic finding in post-streptococcal glomerulonephritis is:
Mesangial proliferation
Crescent formation
Endocapillary proliferation with neutrophils
Membranous thickening of capillary walls
Segmental sclerosis
The "hump-shaped" subepithelial deposits seen on electron microscopy are typical of:
Minimal change disease
Membranoproliferative GN
Post-streptococcal GN
Lupus nephritis (Class IV)
IgA nephropathy
Which of the following is the most likely underlying mechanism in anti-GBM disease?
Circulating immune complexes
In-situ immune complex formation
Autoantibodies directed against type IV collagen
Deposition of IgA immune complexes in the mesangium
Alternative complement pathway activation
The commonest cause of rapidly progressive (crescentic) glomerulonephritis is:
Goodpasture syndrome
Wegener granulomatosis (Granulomatosis with Polyangiitis)
Post-streptococcal GN
Systemic lupus erythematosus
Pauci-immune GN (ANCA-associated)
The presence of RBC casts in urine is most indicative of:
Glomerular bleeding
Lower urinary tract infection
Interstitial nephritis
Acute tubular necrosis
Nephrotic syndrome
Mesangial IgA deposition on immunofluorescence is diagnostic of:
Minimal change disease
IgA nephropathy (Berger disease)
Membranous GN
Diabetic glomerulosclerosis
Anti-GBM nephritis
The "tram-track" appearance of glomerular basement membranes is due to:
Subendothelial deposits and mesangial interposition
Subepithelial immune deposits
Segmental sclerosis
Amyloid deposition
GBM splitting
Which complement component is typically reduced in post-infectious GN?
C1q
C2
C3
C4
C5
The most common presentation of IgA nephropathy is:
Nephritic syndrome
Acute renal failure
Haematuria following upper respiratory infection
Chronic renal failure
Asymptomatic proteinuria
In minimal change disease, the main abnormality seen on electron microscopy is:
Subepithelial deposits
Subendothelial deposits
Effacement of foot processes
Thickened basement membrane
Mesangial interposition
In crescentic glomerulonephritis, crescents are formed mainly by proliferation of:
Mesangial cells
Endothelial cells
Parietal epithelial cells of Bowman’s capsule
Podocytes
Infiltrating lymphocytes
Which of the following is most likely to present with nephrotic rather than nephritic features?
Post-streptococcal GN
Membranous GN
IgA nephropathy
RPGN
Lupus nephritis class IV
The main immunopathologic mechanism in post-infectious GN is:
Anti-GBM antibody formation
Immune complex deposition
Direct bacterial toxin injury
ANCA-mediated vasculitis
Complement deficiency
