WorksheetsGIT COLOGY
Total questions: 27
Worksheet time: 14mins
Which of the following is a proton pump inhibitor (PPI)?
A. Ranitidine
B. Omeprazole
C. Cimetidine
D. Misoprostol
The mechanism of action of omeprazole is:
A. H₂ receptor blockade
B. Inhibition of gastric proton pump (H⁺/K⁺ ATPase)
C. Anticholinergic action
D. Neutralization of gastric acid
Which of the following drugs is a histamine H₂ receptor antagonist?
A. Omeprazole
B. Sucralfate
C. Famotidine
D. Misoprostol
Cimetidine causes which of the following side effects?
A. Hypoglycemia
B. Gynecomastia
C. Constipation
D. Diarrhea
Misoprostol is contraindicated in:
A. Peptic ulcer disease
B. Pregnancy
C. NSAID-induced ulcers
D. Zollinger–Ellison syndrome
Sucralfate acts by:
A. Inhibiting acid secretion
B. Neutralizing acid
C. Forming a protective barrier over ulcers
D. Increasing gastric emptying
Which antacid causes constipation?
A. Magnesium hydroxide
B. Aluminum hydroxide
C. Sodium bicarbonate
D. Calcium carbonate
Which of the following increases gastric motility?
A. Metoclopramide
B. Loperamide
C. Ondansetron
D. Dicyclomine
The mechanism of action of metoclopramide involves:
A. 5-HT₃ receptor blockade
B. D₂ receptor blockade
C. M₃ receptor stimulation
D. H₁ receptor blockade
Domperidone differs from metoclopramide by:
A. Not crossing the blood-brain barrier
B. Having no prokinetic action
C. Being an anticholinergic
D. Causing sedation
Which of the following is effective in motion sickness?
A. Ondansetron
B. Hyoscine
C. Metoclopramide
D. Domperidone
Loperamide acts by:
A. Increasing intestinal motility
B. Decreasing peristalsis via μ-opioid receptor activation
C. Stimulating chloride secretion
D. Blocking D₂ receptors
Lactulose is used for:
A. Diarrhea
B. Peptic ulcer
C. Hepatic encephalopathy
D. Motion sickness
Bulk-forming laxatives include:
A. Castor oil
B. Psyllium
C. Bisacodyl
D. Docusate sodium
The mainstay of therapy for Helicobacter pylori infection is:
A. PPI + antibiotics
B. H₂ blocker alone
C. Antacid + sucralfate
D. Misoprostol alone
Bismuth compounds act by:
A. Inhibiting acid secretion
B. Coating ulcers and killing H. pylori
C. Stimulating mucus production
D. Increasing gastric emptying
A patient with Zollinger–Ellison syndrome is best treated with:
A. Antacids
B. PPIs
C. H2 blockers
D. Anticholinergics
A patient on cimetidine develops gynecomastia because it:
A. Stimulates prolactin
B. Inhibits testosterone metabolism
C. Inhibits estrogen metabolism
D. Increases LH release
Which drug can cause rebound acid secretion on sudden withdrawal?
A. Ranitidine
B. Omeprazole
C. Cimetidine
D. Sucralfate
20. Octreotide is an analogue of:
A. Somatostatin
B. Gastrin
C. Secretin
D. Cholecystokinin
A commonly used carminative agent is:
A. Peppermint oil
B. Omeprazole
C. Loperamide
D. Bisacodyl
A patient on prolonged PPI therapy may develop:
A. Vitamin B12 deficiency
B. Hypoglycemia
C. Hyperkalemia
D. Hypertension
Ursodeoxycholic acid decreases cholesterol in bile by:
A. Inhibiting cholesterol synthesis
B. Solubilizing cholesterol
C. Blocking bile salt absorption
D. Stimulating bile acid synthesis
Which drug decreases LES (lower esophageal sphincter) tone and worsens reflux?
A. Metoclopramide
B. Alcohol
C. Cisapride
D. Domperidone
Rifaximin is used to treat:
A. Traveler’s diarrhea
B. GERD
C. IBS with constipation
D. Peptic ulcer
Alosetron is used in:
A. IBS with constipation
B. IBS with diarrhea
C. Ulcerative colitis
D. Crohn’s disease
Lubiprostone increases intestinal fluid secretion by activating:
A. CFTR chloride channels
B. Voltage-gated sodium channels
C. Potassium channels
D. 5-HT receptors
